ChemicalBook > CAS DataBase List > CLEMASTINE FUMARATE

CLEMASTINE FUMARATE

Product Name
CLEMASTINE FUMARATE
CAS No.
15686-51-8
Chemical Name
CLEMASTINE FUMARATE
Synonyms
CLEMASTINE;Meclastin;CLEMASTINUM;Mecloprodin;Clomastine in methanol;CLEMASTINE FUMARATE SALT;Clemastine for system suitability CRS;Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-;(2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE;Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
CBNumber
CB3376056
Molecular Formula
C21H26ClNO
Formula Weight
343.89
MOL File
15686-51-8.mol
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CLEMASTINE FUMARATE Property

alpha 
D20 +33.6° (ethanol)
Boiling point:
bp0.02 154°
Density 
1.097±0.06 g/cm3(Predicted)
refractive index 
nD22 1.5582
form 
Solid
pka
10.23±0.40(Predicted)
color 
White to off-white
CAS DataBase Reference
15686-51-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0009140
Product name
CLEMASTINE
Purity
95.00%
Packaging
1G
Price
$1529.85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0009140
Product name
CLEMASTINE
Purity
95.00%
Packaging
100G
Price
$4396.22
Updated
2021/12/16
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CLEMASTINE FUMARATE Chemical Properties,Usage,Production

Originator

Tavegyl,Sandoz,France,1967

Uses

Clemastine is used for allergy symptoms, rhinites, Quinke’s edema, anaphylactic shock, hay fever, allergic dermatitis and dermatosis, and chronic eczema. Synonyms of this drug are tavegil and meclastine.

Uses

Antihistaminic.

Definition

ChEBI: 2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative pr perties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.

Manufacturing Process

9.9 g of α-methyl-p-chlorobenzhydrol are added to a suspension of 2.3 g of powdered sodamide in 30 cc of benzene. Subsequently 7.4 g of Nmethylpyrrolidyl-(2)-ethyl chloride are added and the solution is heated to the boil at reflux for 20 hours. Then shaking is first effected with water and then 4 times each time with 25 cc of 2 N hydrochloric acid. The acid extracts are made alkaline with potassium hydroxide solution while cooling strongly, and the precipitated oil is extracted with ether. After drying of the ethereal solution over potassium carbonate, the solvent is evaporated and the residue is fractionally distilled in a high vacuum, whereby N-methyl-2-[2'-(α-methyl-pchlorobenzhydryloxy)-ethyl]-pyrrolidine boils over at 154°C/0.02 mm Hg. The base is converted to the fumarate by reaction with fumaric acid.

brand name

Tavist (Novartis);Aller-ez plus;Alogynan;Antihist-1;Arrest;Benaznyl;Clemastin fumerate syrup;Corto-tavegil;Dexa-tavegil;Fumarsutin;Licasol;Maikohist;Mallermin;Rhinergal tavegil;Tavist 1;Tavist tablets;Tavist-1;Tavist-d;Tavist-syrup.

Therapeutic Function

Antihistaminic

Clinical Use

Antihistamine:
Symptomatic relief of allergy such as hay fever, urticaria

Synthesis

Clemastine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine (16.1.4), is synthesized by reacting 1-(4-chlorophenyl)-1-phenylethanol (16.1.3) with 2- (2-chlorethyl)-2-methylpyrrolidine using sodium amide as a base. The starting 1-(4-chlorophenyl)-1-phenylethanol (16.1.3) is synthesized either by reacting 4-chlorobenzophenone with methylmagnesium chloride, or by reacting 4-chloroacetophenone with phenylmagnesium bromide.

Drug interactions

Potentially hazardous interactions with other drugs
Analgesics: sedative properties increased with opioid analgesics.

Metabolism

Extensively metabolised in the liver mainly by mono- and didemethylation and glucuronide conjugation. The metabolites are mainly excreted in the urine.

CLEMASTINE FUMARATE Preparation Products And Raw materials

Raw materials

Preparation Products

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CLEMASTINE FUMARATE Suppliers

China 40 Europe 2 France 2 Germany 1 India 2 South Korea 1 United Kingdom 6 United States 11 USA 1 Global 66
3B Pharmachem (Wuhan) International Co.,Ltd.
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View Lastest Price from CLEMASTINE FUMARATE manufacturers

Career Henan Chemical Co
Product
clemastine 15686-51-8
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-29

15686-51-8, CLEMASTINE FUMARATERelated Search:

Clemastine fumarate CP2000 CLEMASTINE-D5 HCL CLEMASTINE FUMARATE SALT,CLEMASTINE FUMARATE,Clemastine Fgumarate,clemastine fumurate CLEMASTINE FUMARATE O-T-BUTYLOXYPROPYL AMINE

  • Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-
  • Pyrrolidine, 2-[2-[(p-chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methyl-, (+)- (8CI)
  • [2R,(+)]-2-[2-[[(R)-1-(p-Chlorophenyl)-1-phenylethyl]oxy]ethyl]-1-methylpyrrolidine
  • CLEMASTINE
  • CLEMASTINE FUMARATE SALT
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  • (2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE
  • (+)-(2R)-2-[2-[[(R)-p-Chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine
  • Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
  • Clemastine for system suitability CRS
  • Meclastin
  • Mecloprodin
  • Clomastine in methanol
  • 15686-51-8
  • C21H26ClNO
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