CLEMASTINE FUMARATE
- Product Name
- CLEMASTINE FUMARATE
- CAS No.
- 15686-51-8
- Chemical Name
- CLEMASTINE FUMARATE
- Synonyms
- CLEMASTINE;Meclastin;CLEMASTINUM;Mecloprodin;Clomastine in methanol;CLEMASTINE FUMARATE SALT;Clemastine for system suitability CRS;Pyrrolidine, 2-2-(1R)-1-(4-chlorophenyl)-1-phenylethoxyethyl-1-methyl-, (2R)-;(2R)-2-[2-[(1R)-1-(4-CHLOROPHENYLETHOXY)]ETHYL]-1-METHYL-2-PYRROLIDINE FUMARATE;Pyrrolidine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methyl-, [R-(R*,R*)]-
- CBNumber
- CB3376056
- Molecular Formula
- C21H26ClNO
- Formula Weight
- 343.89
- MOL File
- 15686-51-8.mol
CLEMASTINE FUMARATE Property
- alpha
- D20 +33.6° (ethanol)
- Boiling point:
- bp0.02 154°
- Density
- 1.097±0.06 g/cm3(Predicted)
- refractive index
- nD22 1.5582
- form
- Solid
- pka
- 10.23±0.40(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 15686-51-8(CAS DataBase Reference)
N-Bromosuccinimide Price
- Product number
- API0009140
- Product name
- CLEMASTINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1529.85
- Updated
- 2021/12/16
- Product number
- API0009140
- Product name
- CLEMASTINE
- Purity
- 95.00%
- Packaging
- 100G
- Price
- $4396.22
- Updated
- 2021/12/16
CLEMASTINE FUMARATE Chemical Properties,Usage,Production
Originator
Tavegyl,Sandoz,France,1967
Uses
Clemastine is used for allergy symptoms, rhinites, Quinke’s edema, anaphylactic shock, hay fever, allergic dermatitis and dermatosis, and chronic eczema. Synonyms of this drug are tavegil and meclastine.
Uses
Antihistaminic.
Definition
ChEBI: 2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative pr perties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.
Manufacturing Process
9.9 g of α-methyl-p-chlorobenzhydrol are added to a suspension of 2.3 g of powdered sodamide in 30 cc of benzene. Subsequently 7.4 g of Nmethylpyrrolidyl-(2)-ethyl chloride are added and the solution is heated to the boil at reflux for 20 hours. Then shaking is first effected with water and then 4 times each time with 25 cc of 2 N hydrochloric acid. The acid extracts are made alkaline with potassium hydroxide solution while cooling strongly, and the precipitated oil is extracted with ether. After drying of the ethereal solution over potassium carbonate, the solvent is evaporated and the residue is fractionally distilled in a high vacuum, whereby N-methyl-2-[2'-(α-methyl-pchlorobenzhydryloxy)-ethyl]-pyrrolidine boils over at 154°C/0.02 mm Hg. The base is converted to the fumarate by reaction with fumaric acid.
brand name
Tavist (Novartis);Aller-ez plus;Alogynan;Antihist-1;Arrest;Benaznyl;Clemastin fumerate syrup;Corto-tavegil;Dexa-tavegil;Fumarsutin;Licasol;Maikohist;Mallermin;Rhinergal tavegil;Tavist 1;Tavist tablets;Tavist-1;Tavist-d;Tavist-syrup.
Therapeutic Function
Antihistaminic
Clinical Use
Antihistamine:
Symptomatic relief of allergy such as hay fever,
urticaria
Synthesis
Clemastine, 2-[2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine (16.1.4), is synthesized by reacting 1-(4-chlorophenyl)-1-phenylethanol (16.1.3) with 2- (2-chlorethyl)-2-methylpyrrolidine using sodium amide as a base. The starting 1-(4-chlorophenyl)-1-phenylethanol (16.1.3) is synthesized either by reacting 4-chlorobenzophenone with methylmagnesium chloride, or by reacting 4-chloroacetophenone with phenylmagnesium bromide.
Drug interactions
Potentially hazardous interactions with other drugs
Analgesics: sedative properties increased with opioid
analgesics.
Metabolism
Extensively metabolised in the liver mainly by mono- and didemethylation and glucuronide conjugation. The metabolites are mainly excreted in the urine.
CLEMASTINE FUMARATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CLEMASTINE FUMARATE manufacturers
- Product
- clemastine 15686-51-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- Min98% HPLC
- Supply Ability
- g/kg/ton
- Release date
- 2020-01-29