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Alendronic acid

Product Name
Alendronic acid
CAS No.
66376-36-1
Chemical Name
Alendronic acid
Synonyms
ALENDRONATE;Bisphosphonate;Alendronate Sodium Hydrate;ABDP;R3-RM2;Onclast;Aledronate;alendronicaci;ALENDRONIC ACID;Alendronic Acid >
CBNumber
CB3380835
Molecular Formula
C4H13NO7P2
Formula Weight
249.1
MOL File
66376-36-1.mol
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Alendronic acid Property

Melting point:
230-235°C
Boiling point:
616.7±65.0 °C(Predicted)
Density 
1.857±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
Water Solubility 
Insoluble in water
solubility 
Aqueous Base (Sparingly), Methanol (Slightly), Water (Very Slightly)
form 
powder to crystal
pka
pK1 2.72 ±0.05; pK2 8.73 ±0.05; pK3 10.5 ±0.1; pK4 11.6 ±0.1 at 25°, (0.1M KCl)
color 
White to Light yellow
Merck 
14,229
Stability:
Hygroscopic
EPA Substance Registry System
Phosphonic acid, P,P'-(4-amino-1-hydroxybutylidene)bis- (66376-36-1)
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Safety

RIDADR 
1759
RTECS 
SZ6521833
HS Code 
2931.90.9051
HazardClass 
8
PackingGroup 
III
Hazardous Substances Data
66376-36-1(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical
Product number
A2120
Product name
Alendronic Acid
Purity
>98.0%(T)
Packaging
5g
Price
$67
Updated
2024/03/01
TCI Chemical
Product number
A2120
Product name
Alendronic Acid
Purity
>98.0%(T)
Packaging
25g
Price
$199
Updated
2024/03/01
Chem-Impex
Product number
37567
Product name
Alendronicacid,98%(Assaybytitration)
Purity
98%(Assaybytitration)
Packaging
25G
Price
$217.28
Updated
2021/12/16
Matrix Scientific
Product number
099914
Product name
(4-Amino-1-hydroxybutane-1,1-diyl)diphosphonic acid
Purity
95+%
Packaging
10g
Price
$68
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA38407
Product name
Alendronic acid
Packaging
250g
Price
$312.5
Updated
2021/12/16
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Alendronic acid Chemical Properties,Usage,Production

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate acid is an inhibitor of FDPS.

Definition

ChEBI: A 1,1-bis(phosphonic acid) that is methanebis(phosphonic acid) in which the two methylene hydrogens are replaced by hydroxy and 3-aminopropyl groups.

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

Therapeutic Function

Antiosteoporotic

Hazard

A reproductive hazard.

Clinical Use

Bisphosphonate:
Treatment and prophylaxis of osteoporosis

Drug interactions

Potentially hazardous interactions with other drugs
Calcium salts: reduced absorption of alendronate.

Metabolism

Alendronate transiently distributes to soft tissues but is then rapidly redistributed to bone or excreted in the urine. There is no evidence that alendronate is metabolised in animals or humans. Following a single intravenous dose of [14C]-alendronate, approximately 50% of the radioactivity was excreted in the urine within 72 hours and little or no radioactivity was recovered in the faeces.

Alendronic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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Alendronic acid Suppliers

Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2208
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
94657
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
ShangHai DEMO Chemical Co.,Ltd
Tel
400-021-7337 2355568890
Fax
0086-21-50182339
Email
sales@demochem.com
Country
China
ProdList
2572
Advantage
57
Wuhan Jiakai Long Technology Development Co., Ltd.
Tel
027-88422011
Fax
027-88774279
Country
China
ProdList
26
Advantage
50
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
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View Lastest Price from Alendronic acid manufacturers

Dideu Industries Group Limited
Product
Alendronic acid 66376-36-1
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28
Shaanxi Dideu Medichem Co. Ltd
Product
Alendronic acid 66376-36-1
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99.0%
Supply Ability
600 Tons
Release date
2020-05-03
Career Henan Chemical Co
Product
Alendronic acid 66376-36-1
Price
US $7.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-08-31

66376-36-1, Alendronic acidRelated Search:


  • 4-AMINO-1-HYDROXY-1,1-BUTYLIDINEDIPHOSPHONIC ACID
  • (4-AMINO-1-HYDROXY-1-PHOSPHONOBUTYL)PHOSPHONIC ACID
  • (4-AMINO-1-HYDROXYBUTYLIDENE)-BIS-(PHOSPHONIC ACID)
  • (4-AMINO-1-HYDROXYBUTYLIDENE)DIPHOSPHONIC ACID
  • ALENDRONATE
  • ALENDRONIC ACID
  • (4-amino-1-hydroxybutylidene)bis-phosphonicaci
  • 4-amino-1-hydroxybutylidene-1,1-bis(phosphonicacid)
  • 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid
  • ABDP
  • Onclast
  • AlendronateSodium/AlendronicAcid
  • 1-Hydroxy-4-aminobutylidenebisphosphonic acid
  • 4-Amino-1-hydroxy-1,1-butanediylbisphosphonic acid
  • 4-Amino-1-hydroxybutane-1,1-diylbis(phosphonic acid)
  • Bisphosphonate
  • Alendronate Sodium Hydrate
  • Aledronate
  • Phosphonic acid, (4-aMino-1-hydroxybutylidene)bis-
  • (4-aMino-1-hydroxybutane-1,1-diyl)diphosphonic acid
  • Phosphonic acid,P,P'-(4-aMino-1-hydroxybutylidene)bis-
  • Alendronic Acid &gt
  • alendronicaci
  • Alendronic acid USP/EP/BP
  • R3-RM2
  • Alendronic AcidQ: What is Alendronic Acid Q: What is the CAS Number of Alendronic Acid Q: What is the storage condition of Alendronic Acid Q: What are the applications of Alendronic Acid
  • (4-amino-1-hydroxybutylidene)bis- phosphonic aci 4-amino-1-hydroxybutylidene- 1,1-bis(phosphonic acid) alendronate alendronic acid
  • 66376-36-1
  • 66736-36-1
  • C4H13NO7P2
  • Miscellaneous Biochemicals
  • (intermediate of alendronate sodium)