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Alendronate sodium

Product Name
Alendronate sodium
CAS No.
121268-17-5
Chemical Name
Alendronate sodium
Synonyms
MK-217;Bifosa;NeoBon;Fosamsx;ADRONAT;Fosalan;Fosamax;G-704650;Alendros;Osteovan
CBNumber
CB2145121
Molecular Formula
C4H12NO7P2.Na.3H2O
Formula Weight
325.12
MOL File
121268-17-5.mol
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Alendronate sodium Property

Melting point:
245°C
storage temp. 
-20°C
solubility 
water, double-distilled: 10 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water at 10mg/ml
Merck 
14,229
Stability:
Store in freezer
InChIKey
NKENDYHBVCKCNL-UHFFFAOYSA-M
CAS DataBase Reference
121268-17-5(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-60
WGK Germany 
3
RTECS 
SZ6523500
HS Code 
29310095
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P330Rinse mouth.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
126855
Product name
Alendronate, Sodium Salt
Packaging
100mg
Price
$185
Updated
2021/12/16
Sigma-Aldrich
Product number
Y0001727
Product name
Sodium alendronate trihydrate
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/12/16
Sigma-Aldrich
Product number
1012780
Product name
Alendronate sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/12/16
Sigma-Aldrich
Product number
PHR1599
Product name
Alendronate sodium
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
1g
Price
$95.8
Updated
2021/03/22
Sigma-Aldrich
Product number
A4978
Product name
Alendronate sodium trihydrate
Purity
≥97% (NMR), powder
Packaging
100mg
Price
$214
Updated
2021/03/22
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Alendronate sodium Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.

Uses

A bisphosphonate used as a bone reabsoption inhibitor

Uses

dopamine receptor agonist, antiParkinsonian

Uses

Inhibits bone resorption and increases bone density.

Definition

ChEBI: A hydride that is the trihydrate of alendronate sodium

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

brand name

Fosamax (Merck).

Therapeutic Function

Antiosteoporotic

General Description

Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.

Biochem/physiol Actions

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

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Alendronate sodium Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9918
Advantage
58
Jinan Zhongke Yitong Chemical Co., Ltd.
Tel
0531-88658009- ;0531-88658009
Fax
0531-88956078
Email
lxxcs@163.com;lxxcs@163.com
Country
China
ProdList
83
Advantage
58
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2984
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
future industrial shanghai co., ltd
Tel
400-0066-400;021-60496031
Fax
021-55660885
Email
sales@jonln.com;sales@jonln.com
Country
China
ProdList
1999
Advantage
65
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
Beijing dtftchem Technology Co., Ltd.
Tel
13651141086; 86(10)60275028、60275820
Fax
86 (10) 60270825
Email
dtftchem@sina.com
Country
China
ProdList
3392
Advantage
62
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View Lastest Price from Alendronate sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Alendronate sodium 121268-17-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min HPLC
Supply Ability
500kg
Release date
2021-07-01
Henan Xiangtong Chemical Co., Ltd.
Product
Alendronate sodium 121268-17-5
Price
US $15.00/KG
Min. Order
1KG
Purity
99
Supply Ability
10T
Release date
2020-05-18
Zhuozhou Wenxi import and Export Co., Ltd
Product
Alendronate sodium 121268-17-5
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-26

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