ChemicalBook > CAS DataBase List > Alendronate sodium

Alendronate sodium

Product Name
Alendronate sodium
CAS No.
121268-17-5
Chemical Name
Alendronate sodium
Synonyms
ALENDRONATE SODIUM TRIHYDRATE;Fosamax;Sodium alendronate trihydrate;MK-217;Bifosa;NeoBon;Fosamsx;ADRONAT;Fosalan;G-704650
CBNumber
CB2145121
Molecular Formula
C4H13NO7P2.3H2O.Na
Formula Weight
326.13
MOL File
121268-17-5.mol
More
Less

Alendronate sodium Property

Melting point:
245°C
storage temp. 
-20°C
solubility 
water, double-distilled: 10 mg/mL
form 
solid
color 
white
Water Solubility 
Soluble in water at 10mg/ml
Merck 
14,229
Stability:
Store in freezer
InChIKey
NKENDYHBVCKCNL-UHFFFAOYSA-M
CAS DataBase Reference
121268-17-5(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
22-36/37/38
Safety Statements 
26-36-60
WGK Germany 
3
RTECS 
SZ6523500
HS Code 
29310095
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
126855
Product name
Alendronate, Sodium Salt
Packaging
100mg
Price
$239
Updated
2024/03/01
Sigma-Aldrich
Product number
1012780
Product name
Alendronate sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
A2456
Product name
Alendronate Sodium Trihydrate
Purity
>97.0%(T)
Packaging
5g
Price
$89
Updated
2024/03/01
TCI Chemical
Product number
A2456
Product name
Alendronate Sodium Trihydrate
Purity
>97.0%(T)
Packaging
25g
Price
$267
Updated
2024/03/01
Alfa Aesar
Product number
J61397
Product name
Alendronate sodium trihydrate
Purity
97%
Packaging
1g
Price
$38.65
Updated
2024/03/01
More
Less

Alendronate sodium Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Originator

Adronat ,Neopharmed ,Italy

Uses

Alendronate sodium trihydrate is used as a bone resorption inhibitor, farnesyl diphosphate synthase inhibitor and CD45 protein tyrosine phosphatase inhibitor. A robust inhibitor of bone resorption that induces apoptosis. Alendronate inhibits the migration and invasion of PC-3 cells (sc-2220) by interfering with the mevalonate pathway. Additionally, Alendronate, Sodium Salt is an inhibitor of CD45RC and MMP.

Uses

A bisphosphonate used as a bone reabsoption inhibitor

Uses

dopamine receptor agonist, antiParkinsonian

Uses

Inhibits bone resorption and increases bone density.

Definition

ChEBI: A hydride that is the trihydrate of alendronate sodium

Manufacturing Process

4-Amino-1-hydroxybutylidene-1,1-diphosphonic acid (ABDT).
Orthosphophorous acid (102.7 g; 1.25 moles) is introduced into a 2 liter-flask with condenser, stirrer and dropping funnel, placed on a thermostatized bath; the air is then removed with a nitrogen stream which is continued during all the reaction. The acid is melted by heating the bath to 95°C. When melting is complete, 4-aminobutyric acid (103.3; 1 mole) is added under stirring which is continued till obtaining a doughy fluid. Phosphorous trihalide (176 ml; 2 moles) is added dropwise causing the mixture to boil and evolution of gaseous hydrochloric acid which is damped by means of a suitable trap. The addition rate is adjusted so as to keep a constant reflux for about 60 minutes. When the addition is nearly over, the mixture swells, slowly hardening. Stirring is continued as long as possible, whereafter the mixture is heated for further 3 hours. Without cooling, but removing the bath, water (300 ml) is added, first slowly and then quickly. Heating and stirring are started again. Decolorizing charcoal is added and the mixture is boiled for about 5 minutes, then hotfiltered on paper and the filtrate is refluxed for 6 hours. After cooling is slowly poured in stirred methanol (1500 ml) causing thereby the separation of a white solid which collected and dried (161 g; 64.6%). The structure of ABDT is confirmed by IR spectrum, proton magnetic and nuclear magnetic resonance spectrum and elemental analysis.
The sodium salt of this acid may be prepared by adding of equivalent of sodium hydroxide.

brand name

Fosamax (Merck).

Therapeutic Function

Antiosteoporotic

General Description

Alendronate Sodium, an aminobisphosphonate compound, has been effectively used for the treatment of osteolysis, Paget′s disease and osteoporosis.

Biochem/physiol Actions

Alendronate sodium trihydrate is a bone resorption inhibitor; farnesyl diphosphate synthase inhibitor (IC50 = 460 nM); CD45 protein tyrosine phosphatase inhibitor.

Alendronate sodium Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Alendronate sodium Suppliers

Americas 1 Argentina 2 Austria 2 Belgium 1 Brazil 3 Canada 7 China 347 Czech Republic 2 Europe 5 French Guiana 1 Germany 5 Hungary 1 India 75 Israel 1 Italy 2 Japan 2 Mexico 1 Poland 4 Slovakia 1 South Korea 4 Spain 1 Sweden 1 Switzerland 4 United Arab Emirates 1 United Kingdom 16 United States 56 Global 546
Jai Radhe Sales
Tel
+(91)-(79)-26431096/65255722
Fax
+(91)-(79)-26569884
Email
info@jairadhesales.com
Country
India
ProdList
397
Advantage
60
TCI Chemicals (India) Pvt. Ltd.
Tel
--
Fax
--
Email
sales-in@tcichemicals.com
Country
India
ProdList
6768
Advantage
58
Manus Aktteva
Tel
--
Fax
--
Email
info@manusaktteva.in
Country
India
ProdList
581
Advantage
34
Jigs Chemical Limited
Tel
--
Fax
--
Email
info@jigschemical.com
Country
India
ProdList
235
Advantage
58
Dolace Solutions Private Limited
Tel
--
Fax
--
Email
info@dolacesolutions.com
Country
India
ProdList
240
Advantage
58
Samex Overseas
Tel
--
Fax
--
Country
India
ProdList
124
Advantage
58
Rivashaa Agrotech Biopharma Pvt. Ltd.
Tel
--
Fax
--
Email
source@rivashaa.com
Country
India
ProdList
986
Advantage
58
Bazayan & Co.
Tel
--
Fax
--
Email
info@bazayan.ch
Country
India
ProdList
150
Advantage
58
Shubham Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
shubham@shubham.co.in
Country
India
ProdList
97
Advantage
58
Global Chem Asia Pacific
Tel
--
Fax
--
Email
ghu@globalchem.in
Country
India
ProdList
255
Advantage
58
Sai Prathyu Marketing
Tel
--
Fax
--
Country
India
ProdList
162
Advantage
58
SVS Interchem (SVS)
Tel
--
Fax
--
Email
svsinterchem@gmail.com
Country
India
ProdList
117
Advantage
58
Synpure Labs India Pvt., Ltd.
Tel
--
Fax
--
Email
bhaskargupta@synpurelabs.com
Country
India
ProdList
31
Advantage
58
Shivam Pharma Chemicals
Tel
--
Fax
--
Email
info@shivampharma.com
Country
India
ProdList
656
Advantage
58
SPB Pharma Chiemimpex
Tel
--
Fax
--
Email
sales@spbpharmachem.com
Country
India
ProdList
94
Advantage
58
NIVEDITA CHEMICALS PVT LTD.
Tel
--
Fax
--
Email
nivechem@gmail.com
Country
India
ProdList
14
Advantage
58
B Joshi Agrochem Pharma
Tel
--
Fax
--
Country
India
ProdList
181
Advantage
58
Medkem Laboratories
Tel
--
Fax
--
Email
info@medkem.com
Country
India
ProdList
295
Advantage
58
Raisa Pharmachem Inds.
Tel
--
Fax
--
Email
raisa@bom5.vsnl.net.in
Country
India
ProdList
38
Advantage
58
SynZeal Research Pvt Ltd
Tel
--
Fax
--
Email
standards@synzeal.com
Country
India
ProdList
6514
Advantage
58
Oceanic Pharmachem Pvt. Ltd.
Tel
--
Fax
--
Email
info@oceanicpharmachem.com
Country
India
ProdList
2005
Advantage
58
Rashtriya chemicals Corporation.
Tel
--
Fax
--
Country
India
ProdList
13
Advantage
58
Heer Pharma Pvt., Ltd.
Tel
--
Fax
--
Email
marketing@heerpharma.com
Country
India
ProdList
31
Advantage
58
Exim Corporation
Tel
--
Fax
--
Email
info@eximcorp.com
Country
India
ProdList
179
Advantage
58
Polydrug Laboratories Pvt. Ltd.
Tel
--
Fax
--
Email
polydrug@polydrug.com
Country
India
ProdList
131
Advantage
58
Metro Exporters Pvt. Ltd.
Tel
--
Fax
--
Email
metro@metroexporters.net
Country
India
ProdList
204
Advantage
58
Espee Pharmachem Pvt., Ltd.
Tel
--
Fax
--
Email
info@bulkdrugindia.com
Country
India
ProdList
50
Advantage
58
Clearsynth Labs
Tel
--
Fax
--
Email
fo@clearsynth.com
Country
India
ProdList
3887
Advantage
58
Shagun Pharmaceuticals
Tel
--
Fax
--
Email
info@shagunpharma.com
Country
India
ProdList
193
Advantage
58
Exim-Pharm International
Tel
--
Fax
--
Email
devdhar65@gmail.com
Country
India
ProdList
112
Advantage
58
Global Chemie
Tel
--
Fax
--
Country
India
ProdList
162
Advantage
58
Atman Pharmaceuticals
Tel
--
Fax
--
Email
atman.parekh@atman.net.in
Country
India
ProdList
55
Advantage
58
Apotex Pharmachem India Pvt., Ltd.
Tel
--
Fax
--
Email
mktgapipl@apotex.co.in
Country
India
ProdList
55
Advantage
58
Yashica Pharmaceuticals Private Limited
Tel
--
Fax
--
Email
sales@yashicapharma.com
Country
India
ProdList
49
Advantage
58
Technodrugs & Intermediates (P) Ltd.
Tel
--
Fax
--
Email
info@technodrugs.com
Country
India
ProdList
3
Advantage
58
Ralington Pharma.
Tel
--
Fax
--
Email
info@ralingtonpharma.com
Country
India
ProdList
311
Advantage
58
KPS Chemicals & Pharmaceuticals
Tel
--
Fax
--
Email
kpschempharma@gmail.com
Country
India
ProdList
240
Advantage
58
Bridge Chem Pvt., Ltd.
Tel
--
Fax
--
Email
exports@bridgechem.com
Country
India
ProdList
128
Advantage
58
Ayon PharmaChem
Tel
--
Fax
--
Email
bhargav@ayonpharmachem.com
Country
India
ProdList
303
Advantage
58
Beaukev Pharma International Private Limited
Tel
--
Fax
--
Email
kevin@beaukevpharma.com
Country
India
ProdList
34
Advantage
58
APEX HEALTHCARE LIMITED
Tel
--
Fax
--
Email
sales@apexhealthcareindia.com
Country
India
ProdList
16
Advantage
58
JPN Pharma Pvt., Ltd.
Tel
--
Fax
--
Email
info@jpnpharma.net
Country
India
ProdList
19
Advantage
58
Maas Pharma Chemicals
Tel
--
Fax
--
Email
info@maaspharmachemicals.com
Country
India
ProdList
1607
Advantage
58
Viraj Pharmaceuticals Pvt. Ltd.
Tel
--
Fax
--
Email
virajppl@gmail.com
Country
India
ProdList
162
Advantage
58
Cipla Ltd.
Tel
--
Fax
--
Email
exports@cipla.com
Country
India
ProdList
72
Advantage
58
AUROBINDO PHARMA LIMITED
Tel
--
Fax
--
Email
info@aurobindo.com
Country
India
ProdList
144
Advantage
58
Euroasia Trans Continental
Tel
--
Fax
--
Email
eurasia@vsnl.com
Country
India
ProdList
518
Advantage
47
Pharma Affiliates
Tel
--
Fax
--
Email
@pharmaffiliates.com
Country
India
ProdList
6754
Advantage
58
Vitalchemie Exim Pvt., Ltd.
Tel
--
Fax
--
Email
enquiries@vitalchemie.com
Country
India
ProdList
85
Advantage
58
Chemland Ind
Tel
--
Fax
--
Country
India
ProdList
95
Advantage
58
More
Less

View Lastest Price from Alendronate sodium manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Alendronate sodium 121268-17-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
98.5%min HPLC
Supply Ability
500kg
Release date
2021-07-01
Hebei Weibang Biotechnology Co., Ltd
Product
Alendronate sodium 121268-17-5
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-18
Hebei Weibang Biotechnology Co., Ltd
Product
Alendronate sodium 121268-17-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-05

121268-17-5, Alendronate sodiumRelated Search:

Sodium hydroxide Etidronate disodium Sodium benzoate Sodium chlorite Folic acid Citric acid Glycine 6-Aminocaproic acid Ethyl 2-(Chlorosulfonyl)acetate Diclofenac sodium ALTRENOGEST Sodium risedronate Ibandronate sodium monohydrate Sodium bicarbonate Foscarnet sodium Sodium sulfate Tris(hydroxymethyl)aminomethane Pamidronate disodium salt

  • G-704650
  • Fosamsx
  • 4-amino-1-hydroxy-1-phosphonobutyl phosphonic acid, monosodium, MK-217
  • Alendronate trihydrate sodium
  • P,P'-(4-Amino-1-hydroxybutylidene)bis-phosphonicacidmonosodiumsalt
  • Alendronate Sodium (200 mg)
  • SodiuM Alendronate, EP
  • MonosodiuM Alendronate Trihydrate
  • P,P'-(4-AMino-1-hydroxybutylidene)bisphosphonic Acid SodiuM Salt Hydrate
  • SodiuM Alendronate Hydrate
  • Alendronate SodiuM API
  • Alendronic Acid Monosodium Salt (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate
  • G-704650 Adronat
  • 1,1-DiMethyl-3-Methylthio ethylaMine
  • ALENDRONATE SODIUM SALT
  • ALENDRONATE, SODIUM SALT TRIHYDRATE
  • ALENDRONATE SODIUM TRIHYDRATE
  • ALENDRONNATE SODIUM TRIHYDRATE
  • ALENDRONIC ACID, MONOSODIUM SALT, TRIHYDRATE
  • ADRONAT
  • 4-AMINO-1-HYDROXYBUTYLIDINE-1,1-BISPHOSPHONATE SODIUM SALT TRIHYDRATE
  • MK-217
  • SODIUM, 4-AMINO-1-HYDROXY-1-PHOSPHONO-BUTANE-1-PHOSPHONATE TRIHYDRATE
  • Alendros
  • Bifosa
  • Fosalan
  • Fosamax
  • Monosodium alendronate
  • NeoBon
  • Osteovan
  • Alendronic acid monosodium salt trihydrate - USP
  • Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem
  • Alendronate Monosodium Trihydrate
  • ALENDRONATE SODIUM 3-HYDRATE
  • Alendronate Sodium (Fosamax)
  • (4-amino-1-hydroxybutylidene)bis-phosphonicacimonosodiumsalt
  • aminohydroxybutylidenebiphosphonatemonosodiumsalt
  • monosodium(4-amino-1-hydroxybutylidene)bisphosphonate
  • sodium(4-amino-1-hydroxybutylidene)bisphosphonate
  • MK-217, G-704650, Adronat
  • ALENDRONATESODIUM,EP
  • 4-Amino-1-hydroxybutylidene-1,1-bisphosphonic acid monosodium salt
  • Alendronate sodium
  • Alendronic acid monosodium salt
  • Alendronate MonosodiuM salt trihydrate EP
  • P,P'-(4-amino-1-hydroxybutylidene)bis-phosphonic acid, sodium salt, hydrate (1:1:3)
  • Sodium alendronate trihydrate
  • Monosodium salt trihydrate
  • Alendronate sodium hydrate (MK 217)
  • Alendronate Sodium Salt Trihydrate, 97.0+ % (HPLC)
  • Alendronate Sodium Trihydrate&gt
  • Sodium alendronate for system suitability CRS
  • Sodium alendronate trihydrate CRS
  • Alendronate Sodium RS
  • sodium (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonate)
  • (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonic Acid Monosodium Salt
  • Monosodium (4-Amino-1-hydroxy-1-phosphonobutyl)phosphonate
  • Alendronate sodium trihydrate, ≥97%