4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester

Uses

Product Name: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
CAS No.: 304897-49-2
Chemical Name: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester
Synonyms: 4-(4-Boc-piperazin-1-yl-methyl)aniline;4-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE;4-(4-Aminobenzyl)piperazine, N1-BOC protected;4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline;tert-butyl 4-(4-aMinobenzyl)piperazine-1-carboxylate;4-(4-aminobenzyl)piperazine-1-carboxylic acid tertbut;ert-butyl4-[(4-aminophenyl)methyl]piperazine-1-carboxylate;tert-butyl 4-[(4-aMinophenyl)Methyl]piperazine-1-carboxylate;4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%
CBNumber: CB3386716
Molecular Formula: C16H25N3O2
Formula Weight: 291.39
MOL File: 304897-49-2.mol

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4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Property

Boiling point:: 413.6±40.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
form: solid
pka: 7.16±0.10(Predicted)
Appearance: White to yellow Solid

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: A593945
Product name: 4-(4-Aminobenzyl)piperazine-1-carboxylicacidtert-butylester
Packaging: 100mg
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-1-46
Product name: tert-Butyl 4-[(4-aminophenyl)methyl]piperazine-1-carboxylate
Purity: 98%
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51992
Product name: 4-(1-Boc-piperazin-4-yl-methyl)aniline
Packaging: 250mg
Price: $70
Updated: 2021/12/16

Chem-Impex

Product number: 20156
Product name: 4-(1-Boc-piperazin-4-yl-methyl)aniline,95%(NMR)
Purity: 95%(NMR)
Packaging: 250MG
Price: $86.91
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB51992
Product name: 4-(1-Boc-piperazin-4-yl-methyl)aniline
Packaging: 500mg
Price: $110
Updated: 2021/12/16

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4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production

Uses

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester is a carboxylic acid ester derivative and can be used as a pharmaceutical intermediate.

Synthesis

130636-61-2

304897-49-2

Tert-butyl 4-(4-nitrobenzyl)piperazine-1-carboxylate (1.100 g, 3.423 mmol) was added to a solvent mixture of tetrahydrofuran solution (20 mL) of ammonium chloride (0.915 g, 17.114 mmol) and zinc powder (1.119 g, 17.114 mmol) with water (20 mL) as starting material, and the reaction was stirred for 12 h at room temperature. . Upon completion of the reaction, the reaction mixture was filtered to remove solid impurities. Water was added to the filtrate and subsequently extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The resulting product, tert-butyl 4-(4-aminobenzyl)piperazine-1-carboxylate (0.900 g, 90.2% yield), was a yellow solid and could be used in subsequent reactions without further purification.

References

[1] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 19, p. 5592 - 5599
[2] Patent: US2004/34033, 2004, A1. Location in patent: Page/Page column 12; Sheet 1
[3] Patent: WO2017/18803, 2017, A1. Location in patent: Paragraph 1492; 1493; 1494
[4] Patent: WO2016/146220, 2016, A1. Location in patent: Page/Page column 26; 27
[5] Journal of Medicinal Chemistry, 2018, vol. 61, # 4, p. 1499 - 1518

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

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View Lastest Price from 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2
Price: US $0.10/KG
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 1000 tons
Release date: 2020-04-27

Dideu Industries Group Limited

Product: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons
Release date: 2022-02-18

Career Henan Chemical Co

Product: 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester 304897-49-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: KG/T
Release date: 2019-12-19

304897-49-2, 4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl esterRelated Search:

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4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, 95+%

4-(4-AMINOBENZYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-(1-BOC-PIPERAZIN-4-YL-METHYL)-ANILINE

4-(4-tert-butoxycarbonyl-piperazino-methyl)-aniline

4-(4-Aminobenzyl)piperazine, N1-BOC protected

tert-Butyl 4-(4-aminobenzyl)piperazine-1-carboxylate, 4-{[4-(tert-Butoxycarbonyl)piperazin-1-yl]methyl}aniline

4-(4-Boc-piperazin-1-yl-methyl)aniline

tert-butyl 4-(4-aMinobenzyl)piperazine-1-carboxylate

1-Piperazinecarboxylic acid, 4-[(4-aMinophenyl)Methyl]-, 1,1-diMethylethyl ester

tert-butyl 4-[(4-aMinophenyl)Methyl]piperazine-1-carboxylate

4-(4-aminobenzyl)piperazine-1-carboxylic acid tertbut

ert-butyl4-[(4-aminophenyl)methyl]piperazine-1-carboxylate

4-(4-Aminobenzyl)piperazine-1-carboxylic acid tert-butyl ester ISO 9001：2015 REACH

304897-49-2