L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
- Product Name
- L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
- CAS No.
- 1421-65-4
- Chemical Name
- L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
- Synonyms
- Nsc295453;Melevodopa;Levodopa Impurity 10;LevoMet Hydrochloride;Dopamine, methyl ester;L-DOPA Methyl Ester HCl;methyldopa hydrochloride;Melevodopa Hydrochloride;H-TYR(3-HYDROXY)-OME HCL;METHYL L-DOPA HYDROCHLORIDE
- CBNumber
- CB3398894
- Molecular Formula
- C10H14ClNO4
- Formula Weight
- 247.68
- MOL File
- 1421-65-4.mol
L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Property
- Melting point:
- 174-175℃
- alpha
- +9.0° to +11.0° (20°C, 589nm) (C=2 in methanol)
- storage temp.
- -20°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- solid
- color
- white
- InChI
- InChI=1/C10H13NO4.ClH/c1-15-10(14)7(11)4-6-2-3-8(12)9(13)5-6;/h2-3,5,7,12-13H,4,11H2,1H3;1H/t7-;/s3
- InChIKey
- WFGNJLMSYIJWII-WMASNCOMNA-N
- SMILES
- C1(=CC=C(O)C(O)=C1)C[C@H](N)C(=O)OC.Cl |&1:9,r|
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- D1507
- Product name
- L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
- Purity
- solid
- Packaging
- 1g
- Price
- $206
- Updated
- 2024/03/01
- Product number
- D1507
- Product name
- L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
- Purity
- solid
- Packaging
- 5g
- Price
- $599
- Updated
- 2024/03/01
- Product number
- 16149
- Product name
- L-DOPA methyl ester (hydrochloride)
- Purity
- ≥98%
- Packaging
- 1g
- Price
- $167
- Updated
- 2024/03/01
- Product number
- 16149
- Product name
- L-DOPA methyl ester (hydrochloride)
- Purity
- ≥98%
- Packaging
- 5g
- Price
- $387
- Updated
- 2024/03/01
- Product number
- D1507
- Product name
- L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride
- Purity
- solid
- Packaging
- 500mg
- Price
- $157
- Updated
- 2024/03/01
L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Chemical Properties,Usage,Production
Description
L-DOPA (Item No. 13248) is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine D1 receptor agonist. It is produced from L-tyrosine by trysosine hydroxylase. In the brain, L-DOPA is converted to dopamine by the enzyme aromatic L-amino acid decarboxylase. It is conventionally used to increase dopamine concentrations in the brain as a treatment for Parkinson’s disease and stroke recovery. L-DOPA methyl ester is a neutral derivative of L-DOPA formulated for increased solubility compared to the parent compound.
Chemical Properties
White Solid
Uses
Precursor to L-DOPA that crosses the blood-brain barrier; antiparkinsonian agent.
Uses
L-3,4-Dihydroxyphenylalanine methyl ester hydrochloride has been used:
- in treating 6-hydroxydopamine induced lesions mice serotonin neurons
- in tyrosinase activity in B16F10 skin melanoma cells
- to test its neuroprotective effect in mesencephalic neurons
Uses
Selective Dopamine D1 receptor agonist.
Biochem/physiol Actions
L-3,4-Dihydroxyphenylalanine methyl ester is a precursor to?L-DOPA that crosses the blood-brain barrier. Antiparkinsonian agent L-DOPA methyl ester elicits antitumor functionality in leukemia and melanoma.
in vitro
l-dopa methyl ester is a neutral derivative of l-dopa formulated for increased solubility compared to the parent compound. l-dopa is a metabolic precursor of dopamine that is capable of crossing the blood brain barrier to act as a dopamine d1 receptor agonist [1].
in vivo
on intraperitoneal or subcutaneous administration to mice l-dopa methyl ester was found to be equivalent to l-dopa in reversing reserpine-induced akinesia and producing contraversive circling behaviour in rats. on oral administration the methyl ester was even more active. the administration of l-dopa or the methyl ester had equivalent changes of metabolite levels in striatal and mesolimbic dopamine, homovanillic acid, as well as 3,4-dihydroxyphenylacetic acid [2].
storage
-20°C
References
[1] berends, h. i.,nijlant, j.m.m.,movig, k.l.l., et al. the clinical use of drugs influencing neurotransmitters in the brain to promote motor recovery after stroke; a cochrane systematic review. european journal of physical and rehabilitation medicine 45(4), 621-630 (2009).
[2] cooper dr, marrel c, testa b, van de waterbeemd h, quinn n, jenner p, marsden cd. l-dopa methyl ester--a candidate for chronic systemic delivery of l-dopa in parkinson's disease. clin neuropharmacol. 1984;7(1):89-98.
[3] kleedorfer, b. ,lees, a.j. and stern, g.m. subcutaneous and sublingual levodopa methyl ester in parkinson’s disease. j.neurol.neurosurg.psychiatry 54(4), 373 (1991).
L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE manufacturers
- Product
- L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE 1421-65-4
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 0.99
- Supply Ability
- 100kg
- Release date
- 2024-01-19
- Product
- L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE 1421-65-4
- Price
- US $7.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-21