Ethyl methyldopate hydrochloride
- Product Name
- Ethyl methyldopate hydrochloride
- CAS No.
- 2508-79-4
- Chemical Name
- Ethyl methyldopate hydrochloride
- Synonyms
- METHYLDOPATE HCL;METHYLDOPAETHYLHCL;Ethyl ester hydrochloride;METHYLDOPATE HYDROCHLORIDE;QSRVZCCJDKYRRF-YDALLXLXSA-N;Aldomet Ester hydrochloride;methyldopa ethyl hydrochloride;Ethyl methyldopa hydrochloride;ethyl methyldopate hydrochloride;Methyldopate Hydrochloride (200 mg)
- CBNumber
- CB3746806
- Molecular Formula
- C12H17NO4.ClH
- Formula Weight
- 275.73
- MOL File
- 2508-79-4.mol
Ethyl methyldopate hydrochloride Property
- storage temp.
- 2-8°C
- form
- crystalline powder
Safety
- HS Code
- 2922504500
N-Bromosuccinimide Price
- Product number
- API0006819
- Product name
- METHYLDOPATE HYDROCHLORIDE
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $255.15
- Updated
- 2021/12/16
Ethyl methyldopate hydrochloride Chemical Properties,Usage,Production
Uses
Ethyl methyldopate hydrochloride is Antihypertensive.
brand name
Aldomet (Merck).
General Description
Methyldopatehydrochloride, L-3-(3,4-dihydroxyphenyl)-2-methylalanineethyl ester hydrochloride (Aldomet ester hydrochloride), α-methyldopa, lowers blood pressure by inhibitingthe outflow of sympathetic vasoconstrictor impulses fromthe brain. Early studies had suggested that the hypotensiveaction of α-methyldopa was a result of the peripheral propertiesof the drug as a decarboxylase inhibitor or a falsetransmitter.
Clinical Use
Ethyl methyldopate hydrochloride is used as a step 2 agent and is recommendedfor patients with high blood pressure who are not responsiveto diuretic therapy alone. Ethyl methyldopate hydrochloride, suitable for oral use,is a zwitterion and is not soluble enough for parenteral use.The problem was solved by making the ester, leaving theamine free to form the water-soluble hydrochloride salt. It issupplied as a stable, buffered solution, protected with antioxidantsand chelating agents.
in vivo
Methyldopate is hydrolysed in vivo to methyldopa[2].
IC 50
α adrenergic receptor
Ethyl methyldopate hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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