2-Amino-2-methyl-propionic acid ethyl ester hydrochloride
- Product Name
- 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride
- CAS No.
- 17288-15-2
- Chemical Name
- 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride
- Synonyms
- H-Aib-OEt;H-AIB-OET HCL;L-Aib-OEt·HCl;IFLAB-BB F2108-0015;propanoate hydrochL;H-a-Me-Ala-OEt · HCl;H-α-Me-Ala-OEt · HCl;H-ALPHA-ME-ALA-OET HCL;H-AIB-OET HYDROCHLORIDE;REF DUPL: H-Aib-OEt HCl
- CBNumber
- CB7222805
- Molecular Formula
- C6H14ClNO2
- Formula Weight
- 167.63
- MOL File
- 17288-15-2.mol
2-Amino-2-methyl-propionic acid ethyl ester hydrochloride Property
- Melting point:
- 156-157 °C
- storage temp.
- Inert atmosphere,2-8°C
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C6H13NO2.ClH/c1-4-9-5(8)6(2,3)7;/h4,7H2,1-3H3;1H
- InChIKey
- YREPHXXOTHNLEV-UHFFFAOYSA-N
- SMILES
- C(OCC)(=O)C(C)(C)N.Cl
- CAS DataBase Reference
- 17288-15-2(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- E898855
- Product name
- Ethyl2-Amino-2-methyl-1-propionateHydrochloride
- Packaging
- 250mg
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 14868
- Product name
- a-Aminoisobutyricacidethylesterhydrochloride,99%(HPLC)
- Purity
- 99%(HPLC)
- Packaging
- 1G
- Price
- $16.8
- Updated
- 2021/12/16
- Product number
- AS88171
- Product name
- Ethyl 2-amino-2-methylpropanoate HCl
- Purity
- 95%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 14868
- Product name
- a-Aminoisobutyricacidethylesterhydrochloride,≥99%(HPLC)
- Purity
- ≥99%(HPLC)
- Packaging
- 5G
- Price
- $46.59
- Updated
- 2021/12/16
- Product number
- V3777
- Product name
- H-Aib-OEtHCl
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
2-Amino-2-methyl-propionic acid ethyl ester hydrochloride Chemical Properties,Usage,Production
Uses
An amino acid derivative used in pharmaceutical compositions.
Uses
As an amino acid derivative, 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride can be used in pharmaceutical compositions.
Synthesis
62-57-7
17288-15-2
Thionyl chloride (2.0 molar equivalents) was slowly added dropwise to a stirred solution of anhydrous ethanol (10.0 molar equivalents) pre-cooled to 0 °C under argon protection. The reaction temperature was maintained at 0 °C with continuous stirring for 1 hour and then gradually warmed up to room temperature. Subsequently, 2-aminoisobutyric acid (1.0 molar equivalent) was added and the reaction mixture was heated to reflux overnight. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and finally the residual trace solvent was removed by azeotropic distillation. The crude product was ground with ether to give purified ethyl 2-aminoisobutyrate hydrochloride. In Example 14, ethyl 2-aminoisobutyrate hydrochloride (Product 14n) was prepared according to the method of Example 1 (A) as a white solid (9.12 g, 776.0 mmol) from 2-aminoisobutyric acid (8.0 g, 77.6 mmol), thionyl chloride (11.3 mL, 155.2 mmol) and anhydrous ethanol (45.5 mL, 776.0 mmol). (70% yield). Its 1H-NMR (CDCl3; 300 MHz) and 13C-NMR (CDCl3; 75 MHz) data were consistent with the expected structure.
References
[1] Patent: US2007/42988, 2007, A1. Location in patent: Page/Page column 18; 22
[2] Patent: US6028032, 2000, A
2-Amino-2-methyl-propionic acid ethyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride manufacturers
- Product
- 2-Amino-2-methyl-propionic acid ethyl ester hydrochloride 17288-15-2
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 500kg
- Release date
- 2021-09-01
- Product
- L-Aib-Oet.Hcl 17288-15-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-28
- Product
- Ethyl 2-amino-2-methylpropanoate hydrochloride 17288-15-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-16