Glycine ethyl ester hydrochloride

Product Name: Glycine ethyl ester hydrochloride
CAS No.: 623-33-6
Chemical Name: Glycine ethyl ester hydrochloride
Synonyms: ETHYL GLYCINATE HYDROCHLORIDE;GLYCINE ETHYL ESTER;GLYCINE ETHYL ESTER HCL;GEE;H-GLY-OET HCL;ETHYL AMINOACETATE HYDROCHLORIDE;usafdo-10;ycine EthyL;Gly-OEt HCl;GLYCINE-OET HCL
CBNumber: CB5275670
Molecular Formula: C4H9NO2.ClH
Formula Weight: 139.58
MOL File: 623-33-6.mol

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Glycine ethyl ester hydrochloride Property

Melting point:: 145-146 °C(lit.)
Density: 1.371 g/cm3
storage temp.: 2-8°C
solubility: >1000 g/L (20 °C)
form: Crystalline Powder
pka: pK1:7.66(＋1) (25°C)
color: White
Odor: Odorless
PH: 2.9 (10g/l, H2O, 20℃)
Water Solubility: >1000 g/L (20 ºC)
Sensitive: Hygroscopic
BRN: 3594034
InChIKey: TXTWXQXDMWILOF-UHFFFAOYSA-N
CAS DataBase Reference: 623-33-6(CAS DataBase Reference)
EPA Substance Registry System: Glycine, ethyl ester, hydrochloride (623-33-6)

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Safety

Hazard Codes: Xi
Risk Statements: 41-36/37/38
Safety Statements: 26-39-24/25-37/39
WGK Germany: 3
RTECS: MC0525000
TSCA: Yes
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: G6503
Product name: Glycine ethyl ester hydrochloride
Purity: 99%
Packaging: 5G
Price: $36.5
Updated: 2025/07/31

Sigma-Aldrich

Product number: G6503
Product name: Glycine ethyl ester hydrochloride
Purity: 99%
Packaging: 100g
Price: $67.6
Updated: 2025/07/31

Sigma-Aldrich

Product number: G6503
Product name: Glycine ethyl ester hydrochloride
Purity: 99%
Packaging: 500g
Price: $101
Updated: 2025/07/31

TCI Chemical

Product number: G0102
Product name: Glycine Ethyl Ester Hydrochloride
Purity: >99.0%(T)
Packaging: 25g
Price: $18
Updated: 2025/07/31

TCI Chemical

Product number: G0102
Product name: Glycine Ethyl Ester Hydrochloride
Purity: >99.0%(T)
Packaging: 500g
Price: $71
Updated: 2025/07/31

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Glycine ethyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Uses

As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.

Purification Methods

Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[2] Patent: US2003/236253, 2003, A1. Location in patent: Page 12
[3] Patent: CN107652265, 2018, A. Location in patent: Paragraph 0040; 0041
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 55 - 67
[5] Patent: CN105820102, 2016, A. Location in patent: Paragraph 0038

Glycine ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Hydrogen chloride ethanol solution Ethanol Hydrochloric acid alcohol Glycine Ethanol solution Hydrochloric acid Hydrogen Hexamethylenetetramine

Preparation Products

1-(Boc-amino)cyclopropanecarboxylic acid N-Boc-3-cyano-4-hydroxypyrrolidine ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate ETHYL 2-[(2-THIENYLCARBONYL)AMINO]ACETATE 2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate Ethyl N-(diphenylmethylene)glycinate Ethyl imidazole-4-carboxylate ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER H-GLY-AMC HBR 1-Aminocyclopropanecarboxylic acid Glycine methyl ester hydrochloride N-FORMYLGLYCINE ETHYL ESTER 3-BROMO-6-METHYL-2-OXO-1(2H)-PYRAZINEACETIC ACID ETHYL ESTER Anagrelide ethyl 2-(3,4-dihydro-6-methyl-2,3-dioxopyrazin-1(2H)-yl)acetate Ethyl diazoacetate 4-Imidazolemethanol hydrochloride Tetramethrin 4-BOC-AMINOMETHYL-1-N-BOC-PYRROLIDIN-3-OL 4,5,6,7-TETRAHYDRO-2-METHYLFURO[2,3-C]PYRIDINE

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Glycine ethyl ester hydrochloride Suppliers

Americas 1 Austria 1 Belgium 3 Canada 1 China 609 Europe 5 France 1 Germany 13 Hungary 1 India 67 Japan 8 Poland 1 Slovakia 1 South Korea 1 Switzerland 6 United Kingdom 15 United States 60 Global 794

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View Lastest Price from Glycine ethyl ester hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: Glycine ethyl ester hydrochloride 623-33-6
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: H-Gly-Oet.HCl 623-33-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-03-27

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Glycine ethyl ester hydrochloride 623-33-6
Price: US $79.00-38.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-12-24

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