ChemicalBook > CAS DataBase List > Glycine ethyl ester hydrochloride

Glycine ethyl ester hydrochloride

Product Name
Glycine ethyl ester hydrochloride
CAS No.
623-33-6
Chemical Name
Glycine ethyl ester hydrochloride
Synonyms
ETHYL GLYCINATE HYDROCHLORIDE;GLYCINE ETHYL ESTER;GLYCINE ETHYL ESTER HCL;GEE;H-GLY-OET HCL;ETHYL AMINOACETATE HYDROCHLORIDE;usafdo-10;ycine EthyL;Gly-OEt HCl;GLYCINE-OET HCL
CBNumber
CB5275670
Molecular Formula
C4H9NO2.ClH
Formula Weight
139.58
MOL File
623-33-6.mol
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Glycine ethyl ester hydrochloride Property

Melting point:
145-146 °C(lit.)
Density 
1.371 g/cm3
storage temp. 
2-8°C
solubility 
>1000 g/L (20 °C)
form 
Crystalline Powder
pka
pK1:7.66(＋1) (25°C)
color 
White
Odor
Odorless
PH
2.9 (10g/l, H2O, 20℃)
Water Solubility 
>1000 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3594034
InChIKey
TXTWXQXDMWILOF-UHFFFAOYSA-N
CAS DataBase Reference
623-33-6(CAS DataBase Reference)
EPA Substance Registry System
Glycine, ethyl ester, hydrochloride (623-33-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
41-36/37/38
Safety Statements 
26-39-24/25-37/39
WGK Germany 
3
RTECS 
MC0525000
TSCA 
Yes
HS Code 
29224995
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
5G
Price
$36.5
Updated
2025/07/31
Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
100g
Price
$67.6
Updated
2025/07/31
Sigma-Aldrich
Product number
G6503
Product name
Glycine ethyl ester hydrochloride
Purity
99%
Packaging
500g
Price
$101
Updated
2025/07/31
TCI Chemical
Product number
G0102
Product name
Glycine Ethyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
25g
Price
$18
Updated
2025/07/31
TCI Chemical
Product number
G0102
Product name
Glycine Ethyl Ester Hydrochloride
Purity
>99.0%(T)
Packaging
500g
Price
$71
Updated
2025/07/31
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Glycine ethyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

Crystalline

Uses

Glycine ethyl ester (GEE) is used in conjunction with N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide (EDC) for carboxyl-foot printing studies of proteins. The GEE/EDC protocol effects specific derivatization of glutamate and aspartate carboxyl side chains on intact proteins. This reaction is readily done under aqueous conditions at physiological pH. It is mainly used as a pharmaceutical raw material. Glycine ethyl ester hydrochloride is an important intermediate for preparing chrysanthemic acid or two chlorine chrysanthemic acid and is mainly used in the synthesis of anti-inflammatory drugs, but also can be used for the synthesis of four imidazole acetic acid.

Uses

As a Glycine (G615990) ester, Glycine ethyl ester hydrochloride can be used as parakeratosis inhibitor and external composition for skin.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.

Purification Methods

Crystallise it from absolute EtOH or EtOH/Et2O. [Marvel Org Synth Coll Vol II 310 1943, Beilstein 4 II 780, 4 III 3 75.]

References

[1] Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2006, vol. 45, # 8, p. 1942 - 1944
[2] Patent: US2003/236253, 2003, A1. Location in patent: Page 12
[3] Patent: CN107652265, 2018, A. Location in patent: Paragraph 0040; 0041
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 55 - 67
[5] Patent: CN105820102, 2016, A. Location in patent: Paragraph 0038

Glycine ethyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Hydrogen chloride ethanol solution Ethanol Hydrochloric acid alcohol Glycine Ethanol solution Hydrochloric acid Hydrogen Hexamethylenetetramine

Preparation Products

1-(Boc-amino)cyclopropanecarboxylic acid N-Boc-3-cyano-4-hydroxypyrrolidine ethyl 2-(3-bromo-2-oxopyrazin-1(2H)-yl)acetate ETHYL 2-[(2-THIENYLCARBONYL)AMINO]ACETATE 2,2-Dimethyl-3-(2-methylpropyl)cyclopropanecarboxylic acid p-(methoxymethyl)benzyl ester tert-butyl 3-(aminomethyl)-4-hydroxypyrrolidine-1-carboxylate Ethyl N-(diphenylmethylene)glycinate Ethyl imidazole-4-carboxylate ethyl 2-(3,4-dihydro-2,3-dioxopyrazin-1(2H)-yl)acetate N-(ETHOXYCARBONYL)-N-(ETHOXYCARBONYKLETHYL)GLYCINE ETHYL ESTER H-GLY-AMC HBR 1-Aminocyclopropanecarboxylic acid Glycine methyl ester hydrochloride N-FORMYLGLYCINE ETHYL ESTER 3-BROMO-6-METHYL-2-OXO-1(2H)-PYRAZINEACETIC ACID ETHYL ESTER Anagrelide ethyl 2-(3,4-dihydro-6-methyl-2,3-dioxopyrazin-1(2H)-yl)acetate Ethyl diazoacetate 4-Imidazolemethanol hydrochloride Tetramethrin 4-BOC-AMINOMETHYL-1-N-BOC-PYRROLIDIN-3-OL 4,5,6,7-TETRAHYDRO-2-METHYLFURO[2,3-C]PYRIDINE
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View Lastest Price from Glycine ethyl ester hydrochloride manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
Glycine ethyl ester hydrochloride 623-33-6
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10 mt
Release date
2024-11-29
Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-Gly-Oet.HCl 623-33-6
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-27
Hebei Zhuanglai Chemical Trading Co Ltd
Product
Glycine ethyl ester hydrochloride 623-33-6
Price
US $79.00-38.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-12-24

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