6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- Product Name
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- CAS No.
- 188057-26-3
- Chemical Name
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- Synonyms
- 6-Chloro-2-iodopyridin-3-ol;6-Chloro-2-iodo-3-pyridinol;3-Pyridinol,6-chloro-2-iodo-;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE;6-Chloro-3-hydroxy-2-iodopyridine;3-Hydroxy-6-chloro-2-iodopyridine;6-Chloro-2-iodo-3-hydroxypyridine,98%;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
- CBNumber
- CB3400865
- Molecular Formula
- C5H3ClINO
- Formula Weight
- 255.44
- MOL File
- 188057-26-3.mol
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Property
- Melting point:
- 191-193℃
- Boiling point:
- 333℃
- Density
- 2.219
- Flash point:
- 155℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- solubility
- Slightly Soluble (1.3 g/L) (25°C).
- form
- powder to crystal
- pka
- 4.22±0.10(Predicted)
- color
- White to Yellow to Green
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C5H3ClINO/c6-4-2-1-3(9)5(7)8-4/h1-2,9H
- InChIKey
- FWIMPBYPMQSSCD-UHFFFAOYSA-N
- SMILES
- C1(I)=NC(Cl)=CC=C1O
Safety
- HS Code
- 2933.39.9200
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C3366
- Product name
- 6-Chloro-2-iodo-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $78
- Updated
- 2025/07/31
- Product number
- C3366
- Product name
- 6-Chloro-2-iodo-3-hydroxypyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $231
- Updated
- 2025/07/31
- Product number
- C368863
- Product name
- 6-Chloro-2-iodopyridin-3-ol
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 44635
- Product name
- 6-Chloro-2-iodo-3-hydroxypyridine,≥98%(GC)
- Purity
- ≥98%(GC)
- Packaging
- 1G
- Price
- $68.52
- Updated
- 2021/12/16
- Product number
- HCH0013708
- Product name
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $655.49
- Updated
- 2021/12/16
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Chemical Properties,Usage,Production
Uses
2,2'-Dipyridylamine has been obtained by by heating a mixture of 2-aminopyridine and 2-bromo- (chloro-, iodo- ) -pyridine with anhydrous zinc chloride or with barium oxide.
Synthesis
41288-96-4
188057-26-3
Step 1: 6-Chloropyridin-3-ol (112 g, 868 mmol) was used as a raw material and dissolved in a solvent mixture of THF (800 mL) and water (800 mL). Sodium carbonate (92.0 g, 1.736 mol) and iodine (244.2 g, 1.04 mol) were subsequently added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the aqueous and organic phases were separated and the product was mainly present in the aqueous phase. The aqueous phase product was washed with hexane (400 mL x 2) to remove impurities. Next, the pH of the aqueous phase was adjusted to 7 with hydrochloric acid and extracted with ethyl acetate (500 mL x 4). The organic layers were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain the crude product, which was washed with ethyl acetate to give a final 6-chloro-2-iodopyridin-3-ol 163 g in 75% yield. The structure of the product was confirmed by 1H NMR (DMSO, 400 MHz): δ 11.13 (s, 1H, OH), 7.31 (dd, J = 8.4,12.8 Hz, 2H).
References
[1] Tetrahedron Letters, 2003, vol. 44, # 4, p. 725 - 728
[2] Patent: US6696439, 2004, B1. Location in patent: Page column 20
[3] Patent: WO2015/165428, 2015, A1. Location in patent: Page/Page column 18
[4] Organic Process Research and Development, 2016, vol. 20, # 7, p. 1227 - 1238
[5] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE manufacturers
- Product
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE 188057-26-3
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01
- Product
- 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE 188057-26-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11