ChemicalBook > CAS DataBase List > 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE

6-CHLORO-2-IODO-3-HYDROXYPYRIDINE

Product Name
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
CAS No.
188057-26-3
Chemical Name
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
Synonyms
6-Chloro-2-iodopyridin-3-ol;6-Chloro-2-iodo-3-pyridinol;3-Pyridinol,6-chloro-2-iodo-;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE;6-Chloro-3-hydroxy-2-iodopyridine;3-Hydroxy-6-chloro-2-iodopyridine;6-Chloro-2-iodo-3-hydroxypyridine,98%;6-CHLORO-2-IODO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
CBNumber
CB3400865
Molecular Formula
C5H3ClINO
Formula Weight
255.44
MOL File
188057-26-3.mol
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6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Property

Melting point:
191-193℃
Boiling point:
333℃
Density 
2.219
Flash point:
155℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Slightly Soluble (1.3 g/L) (25°C).
form 
powder to crystal
pka
4.22±0.10(Predicted)
color 
White to Yellow to Green
Sensitive 
Light Sensitive
InChI
InChI=1S/C5H3ClINO/c6-4-2-1-3(9)5(7)8-4/h1-2,9H
InChIKey
FWIMPBYPMQSSCD-UHFFFAOYSA-N
SMILES
C1(I)=NC(Cl)=CC=C1O
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Safety

HS Code 
2933.39.9200
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical
Product number
C3366
Product name
6-Chloro-2-iodo-3-hydroxypyridine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$78
Updated
2025/07/31
TCI Chemical
Product number
C3366
Product name
6-Chloro-2-iodo-3-hydroxypyridine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$231
Updated
2025/07/31
TRC
Product number
C368863
Product name
6-Chloro-2-iodopyridin-3-ol
Packaging
100mg
Price
$60
Updated
2021/12/16
Chem-Impex
Product number
44635
Product name
6-Chloro-2-iodo-3-hydroxypyridine,≥98%(GC)
Purity
≥98%(GC)
Packaging
1G
Price
$68.52
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0013708
Product name
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
Purity
95.00%
Packaging
1G
Price
$655.49
Updated
2021/12/16
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6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Chemical Properties,Usage,Production

Uses

2,2'-Dipyridylamine has been obtained by by heating a mixture of 2-aminopyridine and 2-bromo- (chloro-, iodo- ) -pyridine with anhydrous zinc chloride or with barium oxide.

Synthesis

41288-96-4

188057-26-3

Step 1: 6-Chloropyridin-3-ol (112 g, 868 mmol) was used as a raw material and dissolved in a solvent mixture of THF (800 mL) and water (800 mL). Sodium carbonate (92.0 g, 1.736 mol) and iodine (244.2 g, 1.04 mol) were subsequently added. The reaction mixture was stirred at room temperature for 4 hours. Upon completion of the reaction, the aqueous and organic phases were separated and the product was mainly present in the aqueous phase. The aqueous phase product was washed with hexane (400 mL x 2) to remove impurities. Next, the pH of the aqueous phase was adjusted to 7 with hydrochloric acid and extracted with ethyl acetate (500 mL x 4). The organic layers were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to obtain the crude product, which was washed with ethyl acetate to give a final 6-chloro-2-iodopyridin-3-ol 163 g in 75% yield. The structure of the product was confirmed by 1H NMR (DMSO, 400 MHz): δ 11.13 (s, 1H, OH), 7.31 (dd, J = 8.4,12.8 Hz, 2H).

References

[1] Tetrahedron Letters, 2003, vol. 44, # 4, p. 725 - 728
[2] Patent: US6696439, 2004, B1. Location in patent: Page column 20
[3] Patent: WO2015/165428, 2015, A1. Location in patent: Page/Page column 18
[4] Organic Process Research and Development, 2016, vol. 20, # 7, p. 1227 - 1238
[5] Patent: US2011/76291, 2011, A1. Location in patent: Page/Page column 148

6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-CHLORO-2-IODO-3-HYDROXYPYRIDINE Suppliers

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View Lastest Price from 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE manufacturers

Dideu Industries Group Limited
Product
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE 188057-26-3
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons min
Release date
2021-09-01
Career Henan Chemical Co
Product
6-CHLORO-2-IODO-3-HYDROXYPYRIDINE 188057-26-3
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1ton
Release date
2019-07-11

188057-26-3, 6-CHLORO-2-IODO-3-HYDROXYPYRIDINERelated Search:

6-Chloro-2-fluoropyridine-3-boronic acid 6-Chloro-2-fluoro-3-iodopyridine, 95% 3,5,6-Trichloropyrid 3-Hydroxypyridine 2-IODO-3-HYDROXYPYRIDINE 2-Chloro-5-hydroxypyridine 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE 4-IODO-PYRIDIN-3-OL 2-Chloro-6-iodopyridine

  • 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE
  • 6-Chloro-2-iodopyridin-3-ol
  • 3-Pyridinol,6-chloro-2-iodo-
  • 6-Chloro-2-iodo-3-pyridinol
  • 3-Hydroxy-6-chloro-2-iodopyridine
  • 6-Chloro-2-iodo-3-hydroxypyridine,98%
  • 6-CHLORO-2-IODO-3-HYDROXYPYRIDINE ISO 9001：2015 REACH
  • 6-Chloro-3-hydroxy-2-iodopyridine
  • 188057-26-3
  • Pyridines