GAMMA-ACETYLENIC GABA
- Product Name
- GAMMA-ACETYLENIC GABA
- CAS No.
- 57659-38-8
- Chemical Name
- GAMMA-ACETYLENIC GABA
- Synonyms
- RMI-71645;γ-Acetylenic GABA;4-amino-5-hexynoicaci;GAMMA-ACETYLENIC GABA;4-AMINO-5-HEXYNOIC ACID;5-Hexynoic acid, 4-amino-;gamma-Acetylenic GABA, GABA transaminase inhibitor
- CBNumber
- CB3404858
- Molecular Formula
- C6H9NO2
- Formula Weight
- 127.14
- MOL File
- 57659-38-8.mol
GAMMA-ACETYLENIC GABA Property
- Boiling point:
- 291.1±30.0 °C(Predicted)
- Density
- 1.155±0.06 g/cm3(Predicted)
- solubility
- H2O: 5 mg/mL
- pka
- 4.24±0.10(Predicted)
- form
- solid
- color
- white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- CHM0115182
- Product name
- 4-AMINO-5-HEXYNOIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $642.76
- Updated
- 2021/12/16
GAMMA-ACETYLENIC GABA Chemical Properties,Usage,Production
Uses
γ-Acetylenic GABA (4-Aminohex-5-ynoic acid) is an irreversible inhibitor of GABA-transaminase. γ-Acetylenic GABA can increase the concentration of GABA in rat brain[1][2][3]. γ-Acetylenic GABA is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
in vivo
γ-Acetylenic GABA (100 mg/kg i.p.) inhibits GABA-transaminase activity and causes a several-fold increase in the concentration of GABA in rat brain[2].
References
[1] Casey DE, et, al. gamma-Acetylenic GABA in tardive dyskinesia. Arch Gen Psychiatry. 1980 Dec;37(12):1376-9. DOI:10.1001/archpsyc.1980.01780250062007
[2] Palfreyman MG, et, al. The effect of gamma-acetylenic GABA, an enzyme-activated irreversible inhibitor of GABA-transaminase, on dopamine pathways of the extrapyramidal and limbic systems. Eur J Pharmacol. 1978 Aug 15;50(4):325-36. DOI:10.1016/0014-2999(78)90138-3
[3] Alabed S, et, al. Gamma-aminobutyric acid agonists for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev. 2011 Apr 13;(4):CD000203. DOI:10.1002/14651858.CD000203.pub3
GAMMA-ACETYLENIC GABA Preparation Products And Raw materials
Raw materials
Preparation Products
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