5-HEXYN-1-OL
- Product Name
- 5-HEXYN-1-OL
- CAS No.
- 928-90-5
- Chemical Name
- 5-HEXYN-1-OL
- Synonyms
- Hex-5-yn-1-ol;6-Hydroxy-1-hexyne;5-HEXYN-1-OL;5-hexyn-1-0l;5-Hextyn-1-ol;5-Hexyne-1-ol;5-Hexyn-1-ol>5-HEXYN-1-OL 98%;5-Hexyn-1-ol,97%;5-Hexyn-1-ol, 98 %
- CBNumber
- CB8451448
- Molecular Formula
- C6H10O
- Formula Weight
- 98.14
- MOL File
- 928-90-5.mol
5-HEXYN-1-OL Property
- Melting point:
- -34°C (estimate)
- Boiling point:
- 73-75 °C/15 mmHg (lit.)
- Density
- 0.89 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.450(lit.)
- Flash point:
- 158 °F
- storage temp.
- Inert atmosphere,2-8°C
- form
- Liquid
- pka
- 15.05±0.10(Predicted)
- Specific Gravity
- 0.880
- color
- Colorless to pale yellow
- Water Solubility
- Slightly miscible with water.
- BRN
- 1739774
- InChI
- InChI=1S/C6H10O/c1-2-3-4-5-6-7/h1,7H,3-6H2
- InChIKey
- GOQJMMHTSOQIEI-UHFFFAOYSA-N
- SMILES
- C(O)CCCC#C
- CAS DataBase Reference
- 928-90-5(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 302015
- Product name
- 5-Hexyn-1-ol
- Purity
- 96%
- Packaging
- 1g
- Price
- $48.2
- Updated
- 2025/07/31
- Product number
- 302015
- Product name
- 5-Hexyn-1-ol
- Purity
- 96%
- Packaging
- 5g
- Price
- $100.7
- Updated
- 2025/07/31
- Product number
- H0687
- Product name
- 5-Hexyn-1-ol
- Purity
- >95.0%(GC)
- Packaging
- 5mL
- Price
- $76
- Updated
- 2025/07/31
- Product number
- H0687
- Product name
- 5-Hexyn-1-ol
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $260
- Updated
- 2025/07/31
- Product number
- 302015
- Product name
- 5-Hexyn-1-ol
- Purity
- 96%
- Packaging
- 25g
- Price
- $401
- Updated
- 2025/07/31
5-HEXYN-1-OL Chemical Properties,Usage,Production
Chemical Properties
Clear pale yellow liquid
Uses
5-Hexyn-1-ol is used as starting material for the preparation of terminal alkynes and lactones containing terminal alykyne groups. It is also used in the synthesis of cinnoline-fused cyclic enediyne, llycopodium alkaloids, (+)-nankakurine A and (+)-nankakurine B and 7-benzoyloxy-3-(2-nitrophenylseleno)-1,5-cyclodecadiyne.
Synthesis
18420-41-2
928-90-5
General procedure for the synthesis of 5-hexyn-1-ol from 2-(chloromethyl)tetrahydro-2H-pyran: A small amount of iron(III) nitrate hydrate IX was added as a catalyst to about 100 mL of liquid ammonia at -40 °C. Subsequently, sodium metal (85.3 g, 3.72 mol) was added in small portions. After confirming the formation of sodium amide by observing the change in color of the reaction mixture from dark blue to gray, the reaction was slowly added dropwise, which lasted for 5 hours, after which the reaction mixture was continued to be stirred for 3 hours. Upon completion of the reaction, the cold bath was removed and nitrogen was introduced to accelerate the evaporation of ammonia. Once the ammonia had largely evaporated, water was added slowly and dropwise at ambient temperature to quench the reaction. The reaction mixture was extracted with ether, all organic layers were combined and dried with anhydrous magnesium sulfate. The dried organic phase was filtered, the filtrate was concentrated under reduced pressure to remove the solvent, and the residue was purified by vacuum distillation to give 53.8 g (67% yield) of the target product 5-hexyn-1-ol as a colorless oil.
References
[1] Tetrahedron Letters, 2005, vol. 46, # 38, p. 6449 - 6451
[2] Tetrahedron, 1986, vol. 42, # 7, p. 2017 - 2024
[3] Bulletin of the Chemical Society of Japan, 2017, vol. 90, # 3, p. 298 - 305
[4] Journal of the Chemical Society, 1952, p. 2873,2880
[5] Helvetica Chimica Acta, 1977, vol. 60, p. 1161 - 1174
5-HEXYN-1-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-HEXYN-1-OL manufacturers
- Product
- 5-HEXYN-1-OL 928-90-5
- Price
- US $50.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-22
- Product
- 5-HEXYN-1-OL 928-90-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 97%
- Supply Ability
- 200KG
- Release date
- 2018-08-15