5,8,11-EICOSATRIYNOIC ACID

Product Name: 5,8,11-EICOSATRIYNOIC ACID
CAS No.: 13488-22-7
Chemical Name: 5,8,11-EICOSATRIYNOIC ACID
Synonyms: ETI;EICOSATRIYNOIC ACID;5,8,11-Icosatriynoic acid;Icosa-5,8,11-triynoic acid;5,8,11-EICOSATRIYNOIC ACID;OWYNLPMPYBYKJP-UHFFFAOYSA-N;5,8,11-EICOSATRIYNOIC ACID Basic information;5,8,11-EICOSATRIYNOIC ACID ISO 9001：2015 REACH
CBNumber: CB6705237
Molecular Formula: C20H28O2
Formula Weight: 300.44
MOL File: 13488-22-7.mol

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5,8,11-EICOSATRIYNOIC ACID Property

Melting point:: 70.5-71.5 °C
Boiling point:: 473.8±40.0 °C(Predicted)
Density: 0.990±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Off-white solid.
pka: 4.61±0.10(Predicted)
color: Pale Yellow to Pale Beige
Stability:: Light Sensitive

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 90200
Product name: 5,8,11-Eicosatriynoic Acid
Purity: ≥99%
Packaging: 1mg
Price: $85
Updated: 2024/03/01

Cayman Chemical

Product number: 90200
Product name: 5,8,11-Eicosatriynoic Acid
Purity: ≥99%
Packaging: 5mg
Price: $359
Updated: 2024/03/01

Cayman Chemical

Product number: 90200
Product name: 5,8,11-Eicosatriynoic Acid
Purity: ≥99%
Packaging: 10mg
Price: $633
Updated: 2024/03/01

TRC

Product number: E936910
Product name: ETI
Packaging: 250mg
Price: $1325
Updated: 2021/12/16

ApexBio Technology

Product number: C5811
Product name: 5,8,11-EicosatriynoicAcid
Packaging: 10mg
Price: $732
Updated: 2021/12/16

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5,8,11-EICOSATRIYNOIC ACID Chemical Properties,Usage,Production

Uses

ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.

Definition

ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions.

Biological Activity

5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2].

References

[1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6.

5,8,11-EICOSATRIYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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5,8,11-EICOSATRIYNOIC ACID Suppliers

China 37 Germany 1 India 1 Switzerland 3 United Kingdom 1 United States 14 Global 57

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View Lastest Price from 5,8,11-EICOSATRIYNOIC ACID manufacturers

Henan Bao Enluo International TradeCo.，LTD

Product: 5,8,11-EICOSATRIYNOIC ACID 13488-22-7
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 10000MT
Release date: 2023-07-24

Guangzhou Sunton Biotechnology Co., Ltd.

Product: 5,8,11-EICOSATRIYNOIC ACID 13488-22-7
Price: US $50.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 tons
Release date: 2021-05-07

Hebei Anda Technology Co., LTD

Product: ETI 13488-22-7
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: Ex 20 tons
Release date: 2022-10-21

13488-22-7, 5,8,11-EICOSATRIYNOIC ACIDRelated Search:

Baicalein PD 146176 CDC Caffeic acid Esculetin REV 5901 BW B70C 15(S)-HEDE 5,8,11-EICOSATRIYNOIC ACID 5-HEXYN-1-OL 1,4-DECADIYNE 3-UNDECYNE 5-HEXYNOIC ACID 1,4-HEPTADIYNE 1,4-PENTADIYNE 1,4-HEXADIYNE 2,5-HEPTADIYNE 3-DODECYNE

EICOSATRIYNOIC ACID

ETI

5,8,11-EICOSATRIYNOIC ACID

Icosa-5,8,11-triynoic acid

5,8,11-Icosatriynoic acid

OWYNLPMPYBYKJP-UHFFFAOYSA-N

5,8,11-EICOSATRIYNOIC ACID Basic information

5,8,11-EICOSATRIYNOIC ACID ISO 9001：2015 REACH

13488-22-7

Biochemicals and Reagents

BioChemical

L to O

Lipoxygenase (5 and 12-); does not inhibit cyclooxygenase.

Enzymes, Inhibitors, and Substrates

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme