5,8,11-EICOSATRIYNOIC ACID
- Product Name
- 5,8,11-EICOSATRIYNOIC ACID
- CAS No.
- 13488-22-7
- Chemical Name
- 5,8,11-EICOSATRIYNOIC ACID
- Synonyms
- ETI;EICOSATRIYNOIC ACID;5,8,11-Icosatriynoic acid;Icosa-5,8,11-triynoic acid;5,8,11-EICOSATRIYNOIC ACID;OWYNLPMPYBYKJP-UHFFFAOYSA-N;5,8,11-EICOSATRIYNOIC ACID Basic information;5,8,11-EICOSATRIYNOIC ACID ISO 9001:2015 REACH
- CBNumber
- CB6705237
- Molecular Formula
- C20H28O2
- Formula Weight
- 300.44
- MOL File
- 13488-22-7.mol
5,8,11-EICOSATRIYNOIC ACID Property
- Melting point:
- 70.5-71.5 °C
- Boiling point:
- 473.8±40.0 °C(Predicted)
- Density
- 0.990±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- form
- Off-white solid.
- pka
- 4.61±0.10(Predicted)
- color
- Pale Yellow to Pale Beige
- Stability:
- Light Sensitive
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 90200
- Product name
- 5,8,11-Eicosatriynoic Acid
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $85
- Updated
- 2024/03/01
- Product number
- 90200
- Product name
- 5,8,11-Eicosatriynoic Acid
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $359
- Updated
- 2024/03/01
- Product number
- 90200
- Product name
- 5,8,11-Eicosatriynoic Acid
- Purity
- ≥99%
- Packaging
- 10mg
- Price
- $633
- Updated
- 2024/03/01
- Product number
- E936910
- Product name
- ETI
- Packaging
- 250mg
- Price
- $1325
- Updated
- 2021/12/16
- Product number
- C5811
- Product name
- 5,8,11-EicosatriynoicAcid
- Packaging
- 10mg
- Price
- $732
- Updated
- 2021/12/16
5,8,11-EICOSATRIYNOIC ACID Chemical Properties,Usage,Production
Uses
ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.
Definition
ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions.
Biological Activity
5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2].
References
[1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6.
5,8,11-EICOSATRIYNOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5,8,11-EICOSATRIYNOIC ACID manufacturers
- Product
- 5,8,11-EICOSATRIYNOIC ACID 13488-22-7
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-07-24
- Product
- 5,8,11-EICOSATRIYNOIC ACID 13488-22-7
- Price
- US $50.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 tons
- Release date
- 2021-05-07
- Product
- ETI 13488-22-7
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- Ex 20 tons
- Release date
- 2022-10-21