ChemicalBook > CAS DataBase List > 5,8,11-EICOSATRIYNOIC ACID

5,8,11-EICOSATRIYNOIC ACID

Product Name
5,8,11-EICOSATRIYNOIC ACID
CAS No.
13488-22-7
Chemical Name
5,8,11-EICOSATRIYNOIC ACID
Synonyms
ETI;EICOSATRIYNOIC ACID;5,8,11-Icosatriynoic acid;Icosa-5,8,11-triynoic acid;5,8,11-EICOSATRIYNOIC ACID;OWYNLPMPYBYKJP-UHFFFAOYSA-N;5,8,11-EICOSATRIYNOIC ACID Basic information;5,8,11-EICOSATRIYNOIC ACID ISO 9001：2015 REACH
CBNumber
CB6705237
Molecular Formula
C20H28O2
Formula Weight
300.44
MOL File
13488-22-7.mol
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5,8,11-EICOSATRIYNOIC ACID Property

Melting point:
70.5-71.5 °C
Boiling point:
473.8±40.0 °C(Predicted)
Density 
0.990±0.06 g/cm3(Predicted)
storage temp. 
−20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Off-white solid.
pka
4.61±0.10(Predicted)
color 
Pale Yellow to Pale Beige
Stability:
Light Sensitive
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
90200
Product name
5,8,11-Eicosatriynoic Acid
Purity
≥99%
Packaging
1mg
Price
$85
Updated
2024/03/01
Cayman Chemical
Product number
90200
Product name
5,8,11-Eicosatriynoic Acid
Purity
≥99%
Packaging
5mg
Price
$359
Updated
2024/03/01
Cayman Chemical
Product number
90200
Product name
5,8,11-Eicosatriynoic Acid
Purity
≥99%
Packaging
10mg
Price
$633
Updated
2024/03/01
TRC
Product number
E936910
Product name
ETI
Packaging
250mg
Price
$1325
Updated
2021/12/16
ApexBio Technology
Product number
C5811
Product name
5,8,11-EicosatriynoicAcid
Packaging
10mg
Price
$732
Updated
2021/12/16
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5,8,11-EICOSATRIYNOIC ACID Chemical Properties,Usage,Production

Uses

ETI is a leukotriene antagonist and selective 5-LO (5-lipoxygenase) inhibitor.

Definition

ChEBI: A C20 polyunsaturated fatty acid having three triple bonds in the 5-, 8- and 11-positions.

Biological Activity

5,8,11-eicosatriynoic acid is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase , respectively[1][2].fatty acid cycle-oxygenase and n-8 lipoxygenase catalyze the initial reactions which lead to the formation of three major arachidonic acid metabolites in human platelets. in several tissues, these two enzymes act concomitantly on arachidonic acid [1].5,8,11-eicosatriynoic acid (5,8,11-et) is a selective inhibitor of lipoxygenases with id50 values of 24 μm and 340 μm for n-8 lipoxygenase and fatty acid cycle-oxygenase, respectively. 5,8,11-eicosatriynoic acid was useful for studies on physiological and pathophysiological roles of 12 l-hydroxy-5,8,10,14-eicosatetraenoic acid formation in various tissues [1]. in mouse mastocytoma cells, 5,8,11-eicosatriynoic acid inhibited a23187 and l-cysteine induced leukotriene c (ltc4) biosynthesis with id50 value of 5 μm [2].

References

[1]. hammarstrm s. selective inhibition of platelet n-8 lipoxygenase by 5,8,11-eicosatriynoic acid. biochim biophys acta. 1977 jun 22;487(3):517-9.
[2]. orning l, hammarstrm s. inhibition of leukotriene c and leukotriene d biosynthesis. j biol chem. 1980 sep 10;255(17):8023-6.

5,8,11-EICOSATRIYNOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,8,11-EICOSATRIYNOIC ACID manufacturers

Henan Bao Enluo International TradeCo.，LTD
Product
5,8,11-EICOSATRIYNOIC ACID 13488-22-7
Price
US $50.00/kg
Min. Order
1kg
Purity
99.9%
Supply Ability
10000MT
Release date
2023-07-24
Guangzhou Sunton Biotechnology Co., Ltd.
Product
5,8,11-EICOSATRIYNOIC ACID 13488-22-7
Price
US $50.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20 tons
Release date
2021-05-07
Hebei Anda Technology Co., LTD
Product
ETI 13488-22-7
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
Ex 20 tons
Release date
2022-10-21

13488-22-7, 5,8,11-EICOSATRIYNOIC ACIDRelated Search:

Baicalein PD 146176 CDC Caffeic acid Esculetin REV 5901 BW B70C 15(S)-HEDE 5,8,11-EICOSATRIYNOIC ACID 5-HEXYN-1-OL 1,4-DECADIYNE 3-UNDECYNE 5-HEXYNOIC ACID 1,4-HEPTADIYNE 1,4-PENTADIYNE 1,4-HEXADIYNE 2,5-HEPTADIYNE 3-DODECYNE

  • EICOSATRIYNOIC ACID
  • ETI
  • 5,8,11-EICOSATRIYNOIC ACID
  • Icosa-5,8,11-triynoic acid
  • 5,8,11-Icosatriynoic acid
  • OWYNLPMPYBYKJP-UHFFFAOYSA-N
  • 5,8,11-EICOSATRIYNOIC ACID Basic information
  • 5,8,11-EICOSATRIYNOIC ACID ISO 9001：2015 REACH
  • 13488-22-7
  • Biochemicals and Reagents
  • BioChemical
  • L to O
  • Lipoxygenase (5 and 12-); does not inhibit cyclooxygenase.
  • Enzymes, Inhibitors, and Substrates
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme