ChemicalBook > CAS DataBase List > REV 5901

REV 5901

Product Name
REV 5901
CAS No.
101910-24-1
Chemical Name
REV 5901
Synonyms
RG-5901;PF-5901;REV 5901;RG-5901A;1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol;2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline;α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol;Benzenemethanol,a-pentyl-3-(2-quinolinylmethoxy)-;Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-;3-[(Quinolin-2-yl)methoxy]-α-pentylbenzenemethanol
CBNumber
CB0784207
Molecular Formula
C22H25NO2
Formula Weight
335.44
MOL File
101910-24-1.mol
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REV 5901 Property

Boiling point:
497.7±35.0 °C(Predicted)
Density 
1.123±0.06 g/cm3(Predicted)
storage temp. 
Room temperature
solubility 
≤100mg/ml in ethanol;100mg/ml in methanol;100mg/ml in acetone;100mg/ml in DMSO;100mg/ml in etonitrile.
form 
Off-white to tan solid.
pka
14.48±0.20(Predicted)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
70600
Product name
REV 5901
Purity
≥98%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
70600
Product name
REV 5901
Purity
≥98%
Packaging
10mg
Price
$61
Updated
2024/03/01
Cayman Chemical
Product number
70600
Product name
REV 5901
Purity
≥98%
Packaging
50mg
Price
$243
Updated
2024/03/01
Cayman Chemical
Product number
70600
Product name
REV 5901
Purity
≥98%
Packaging
100mg
Price
$426
Updated
2024/03/01
TRC
Product number
L009508
Product name
L-655,238
Packaging
25mg
Price
$145
Updated
2021/12/16
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REV 5901 Chemical Properties,Usage,Production

Description

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM.

Uses

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM.

Uses

L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein).

Definition

ChEBI: 1-[3-(2-quinolinylmethoxy)phenyl]-1-hexanol is a member of quinolines.

in vitro

previous in-vitro showed that rev 5901 had a ki value of 0.7 μm vs. [3h]leukotriene d4 ([3h]-ltd4) binding to membranes from guinea pig lung. against ltc4-, ltd4- and lte4-induced contractions of guinea pig parenchymal strips, rev 5901 had kb values of ca 3 μm and was relatively ineffective against contractions that was induced by other spasmogens. moreover, in isolated guinea pig hearts, the peptiodoleukotriene-antagonist activity was also observed against the hemodynamic and vasoconstriction effects of ltd4. in addition, unlike other reported antagonists, rev 5901 was found to be ineffective against the multiple forms of cyclic nucleotide phosphodiesterases [1].

in vivo

animal study found that the oral antagonist activity had been shown with an ltd4-induced bronchoconstriction model and with an ltd4-induced wheal response model in guinea pigs [1].

References

[1] van inwegen, r. g.,khandwala, a.,gordon, r., et al. rev 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. journal of pharmacology and experimental therapeutics 241, 117-124 (1987).

REV 5901 Preparation Products And Raw materials

Raw materials

Preparation Products

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REV 5901 Suppliers

Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9806
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44806
Advantage
58
Shanghai Dexuan Pharmaceutical Technology Co., Ltd
Tel
1701086315
Fax
1701086315@qq.com
Email
dexuanpharma@126.com
Country
China
ProdList
9475
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Yingxin laboratory equipment Co., Ltd
Tel
021-021-59178156 15300768757
Email
359382369@qq.com
Country
China
ProdList
10674
Advantage
58
Shanghai Guchen Biotechnology Co., LTD
Tel
021-34675735 19147740836
Email
1986399151@qq.com
Country
China
ProdList
9844
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
+86-18521732826
Email
market@aladdin-e.com
Country
China
ProdList
48461
Advantage
58

101910-24-1, REV 5901Related Search:


  • ALPHA-PENTYL-3-(2-QUINOLINYLMETHOXY)-BENZENEMETHANOL
  • ALPHA-PENTYL-3-[2-QUINOLINYLMETHOXY]BENZYL ALCOHOL
  • REV 5901
  • α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol
  • 2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline
  • 3-[(Quinolin-2-yl)methoxy]-α-pentylbenzenemethanol
  • PF-5901
  • RG-5901
  • RG-5901A
  • 1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol
  • Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
  • Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-
  • Benzenemethanol,a-pentyl-3-(2-quinolinylmethoxy)-
  • 101910-24-1
  • BioChemical
  • Biochemicals and Reagents
  • Enzyme Inhibitors
  • Enzyme Inhibitors by Enzyme
  • Enzymes, Inhibitors, and Substrates
  • Lipoxygenase (5-)
  • L to O