REV 5901

Product Name: REV 5901
CAS No.: 101910-24-1
Chemical Name: REV 5901
Synonyms: RG-5901;PF-5901;REV 5901;RG-5901A;1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol;2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline;α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol;Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-;3-[(Quinolin-2-yl)methoxy]-α-pentylbenzenemethanol;ALPHA-PENTYL-3-[2-QUINOLINYLMETHOXY]BENZYL ALCOHOL
CBNumber: CB0784207
Molecular Formula: C22H25NO2
Formula Weight: 335.44
MOL File: 101910-24-1.mol

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REV 5901 Property

Boiling point:: 497.7±35.0 °C(Predicted)
Density: 1.123±0.06 g/cm3(Predicted)
storage temp.: Room temperature
solubility: ≤100mg/ml in ethanol;100mg/ml in methanol;100mg/ml in acetone;100mg/ml in DMSO;100mg/ml in etonitrile.
form: Off-white to tan solid.
pka: 14.48±0.20(Predicted)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 70600
Product name: REV 5901
Purity: ≥98%
Packaging: 5mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 70600
Product name: REV 5901
Purity: ≥98%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 70600
Product name: REV 5901
Purity: ≥98%
Packaging: 50mg
Price: $243
Updated: 2024/03/01

Cayman Chemical

Product number: 70600
Product name: REV 5901
Purity: ≥98%
Packaging: 100mg
Price: $426
Updated: 2024/03/01

TRC

Product number: L009508
Product name: L-655,238
Packaging: 25mg
Price: $145
Updated: 2021/12/16

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REV 5901 Chemical Properties,Usage,Production

Description

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a K_i value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC₅₀ value of 0.12 μM.

Uses

REV 5901 is an antagonist of cysteinyl-leukotriene receptors with a Ki value of 0.7 μM for guinea pig lung membranes. It is also an inhibitor of rat neutrophil 5-LO with an IC50 value of 0.12 μM.

Uses

L-655,238 is a potent and selective inhibitor of FLAP (5-LO-activating protein).

Definition

ChEBI: 1-[3-(2-quinolinylmethoxy)phenyl]-1-hexanol is a member of quinolines.

in vitro

previous in-vitro showed that rev 5901 had a ki value of 0.7 μm vs. [3h]leukotriene d4 ([3h]-ltd4) binding to membranes from guinea pig lung. against ltc4-, ltd4- and lte4-induced contractions of guinea pig parenchymal strips, rev 5901 had kb values of ca 3 μm and was relatively ineffective against contractions that was induced by other spasmogens. moreover, in isolated guinea pig hearts, the peptiodoleukotriene-antagonist activity was also observed against the hemodynamic and vasoconstriction effects of ltd4. in addition, unlike other reported antagonists, rev 5901 was found to be ineffective against the multiple forms of cyclic nucleotide phosphodiesterases [1].

in vivo

animal study found that the oral antagonist activity had been shown with an ltd4-induced bronchoconstriction model and with an ltd4-induced wheal response model in guinea pigs [1].

References

[1] van inwegen, r. g.,khandwala, a.,gordon, r., et al. rev 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile. journal of pharmacology and experimental therapeutics 241, 117-124 (1987).

REV 5901 Preparation Products And Raw materials

Raw materials

Preparation Products

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REV 5901 Suppliers

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101910-24-1, REV 5901Related Search:

15(S)-HPEDE PD 146176 CDC 5,8,11-EICOSATRIYNOIC ACID Caffeic acid BW B70C 15(S)-HEDE Esculetin Baicalein REV 5901, PARA ISOMER REV 5901

ALPHA-PENTYL-3-(2-QUINOLINYLMETHOXY)-BENZENEMETHANOL

ALPHA-PENTYL-3-[2-QUINOLINYLMETHOXY]BENZYL ALCOHOL

REV 5901

α-pentyl-3-[2-quinolinylmethoxy]benzyl alcohol

2-[3-(1-Hydroxyhexyl)phenoxymethyl]quinoline

3-[(Quinolin-2-yl)methoxy]-α-pentylbenzenemethanol

PF-5901

RG-5901

RG-5901A

1-[3-(quinolin-2-ylmethoxy)phenyl]hexan-1-ol

Benzenemethanol, α-pentyl-3-(2-quinolinylmethoxy)-

101910-24-1

BioChemical

Biochemicals and Reagents

Enzyme Inhibitors

Enzyme Inhibitors by Enzyme

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Lipoxygenase (5-)

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