PP2

Background References

Product Name: PP2
Chemical Name: PP2
Synonyms: PP2;CP-118556;6-Dimethylamino-2-phenyl-3(2H)-pyridazinone
CBNumber: CB3406579
Formula Weight: 0
MOL File: Mol file

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PP2 Property

storage temp.: -20°C
form: powder
color: white to off-white

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Safety

RIDADR: UN 2811 6.1 / PGIII

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 529576
Product name: PP2
Purity: InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
Packaging: 1mg
Price: $207
Updated: 2025/07/31

Tocris

Product number: 1407
Product name: PP2
Purity: ≥99%(HPLC)
Packaging: 10
Price: $288
Updated: 2021/12/16

Usbiological

Product number: 045164
Product name: PP2
Packaging: 1mg
Price: $282
Updated: 2021/12/16

Usbiological

Product number: 256305
Product name: PP 2
Packaging: 10mg
Price: $545
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb545896
Product name: PP2
Purity: >98%
Packaging: 5mg
Price: $173.4
Updated: 2021/12/16

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PP2 Chemical Properties,Usage,Production

Biological Activity

Cell permeable: no', 'Primary Target
p56lck', 'Product competes with ATP.', 'Reversible: yes', 'Target IC50: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells

Background

PP2 is a potent and selective inhibitor of Src-family kinases. This small molecule inhibits Lck, Fyn, and Hck with little to no effect on ZAP-70 and JAK2. Members of the Src family are involved in the regulation of cellular excitability and synaptic plasticity. Inhibition of Src family nonreceptor protein tyrosine kinases can decrease epileptiform activity, making PP2 an important compound when studying epilepsy and antiepileptic therapies.

References

[1] Hanke, J.H. et al. (1996) J Biol Chem 271, 695-701.
[2] Sanna, P.P. et al. (2000) Proc Natl Acad Sci U S A 97, 8653-7.

PP2 Preparation Products And Raw materials

Raw materials

Preparation Products

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PP2 Suppliers

China 78 Japan 2 United Kingdom 1 United States 4 Global 85

MedChemexpress LLC

Tel: 021-58955995
Fax: 609-228-5909
Email: sales@medchemexpress.cn
Country: United States
ProdList: 4861
Advantage: 58

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51395
Advantage: 80

Shanghai Zeye Biotechnology Co., Ltd.

Tel: 021-02161998551 13122364865
Email: sale1@shzysw.net
Country: China
ProdList: 9779
Advantage: 58

Wuhan Yanzhe Technology Co., Ltd

Tel: 15527250409
Fax: QQ：2692360204
Email: wenhaotian12@163.com
Country: China
ProdList: 4171
Advantage: 58

bioleaper

Tel: 4000880777 17585207275
Email: guojing@bioleaper.com
Country: China
ProdList: 5616
Advantage: 58

Adipogen Life Sciences

Tel: 41-6192660-40
Email: info@adipogen.com
Country: China
ProdList: 5293
Advantage: 58

StressMarq Biosciences Inc

Tel: 1250-294-9065
Email: info@stressmarq.com
Country: China
ProdList: 3181
Advantage: 58

Cayman Chemical Company

Tel: 800-364-9897
Email: sales@caymanchem.com
Country: China
ProdList: 6838
Advantage: 58

Enzo Biochem Inc

Tel: Enzo Biochem Inc. 13797054060
Email: Enzoname@qq.com
Country: China
ProdList: 6174
Advantage: 58

Cell Signaling Technology Inc

Tel: 21-80243558 86218024
Email: info@cellsignal.cn
Country: China
ProdList: 6725
Advantage: 58

PP2Related Search:

PP2A p2Y4 PP2

PP2

CP-118556

6-Dimethylamino-2-phenyl-3(2H)-pyridazinone