1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE
- Product Name
- 1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE
- CAS No.
- 118753-66-5
- Chemical Name
- 1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE
- Synonyms
- 101g;BOC-PAZ-NH2;4-aminopiperazine-1-carboxyL;1-T-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE;tert-Butyl 4-aMinopiperazin-1-carboxylate;1-Amino-4-(tert-butoxycarbonyl)piperazine;1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE;4-AMino-piperazine-1-carboxylic acid tert-butyl ester;4-Amino-1-piperazinecarboxylic acid 1,1-dimethylethyl ester;1-PIPERAZINECARBOXYLIC ACID,4-AMINO-,1,1-DIMETHYLETHYL ESTER
- CBNumber
- CB3412165
- Molecular Formula
- C9H19N3O2
- Formula Weight
- 201.27
- MOL File
- 118753-66-5.mol
1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE Property
- Boiling point:
- 281℃
- Density
- 1.097
- Flash point:
- 124℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 7.03±0.20(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C9H19N3O2/c1-9(2,3)14-8(13)11-4-6-12(10)7-5-11/h4-7,10H2,1-3H3
- InChIKey
- QMZFIRHRGPLKEV-UHFFFAOYSA-N
- SMILES
- N1(C(OC(C)(C)C)=O)CCN(N)CC1
Safety
- RIDADR
- UN2735
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B750343
- Product name
- tert-Butyl4-Aminopiperazine-1-carboxylate
- Packaging
- 500mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- FB166355
- Product name
- tert-Butyl 4-aminopiperazine-1-carboxylate
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- FB166355
- Product name
- tert-Butyl 4-aminopiperazine-1-carboxylate
- Packaging
- 500mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- FB166355
- Product name
- tert-Butyl 4-aminopiperazine-1-carboxylate
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 4H56-1-738
- Product name
- tert-Butyl 4-aminopiperazine-1-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE Chemical Properties,Usage,Production
Synthesis
877177-42-9
118753-66-5
General procedure for the synthesis of tert-butyl 4-aminopiperazine-1-carboxylate from tert-butyl 4-nitroso piperazine-1-carboxylate: At room temperature, the compound (730 mg) obtained in step (1) was dissolved in methanol (10 mL) and zinc powder (1.1 g) was added. Acetic acid (10 mL) was added slowly and dropwise under cooling in an ice bath. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the mixture was filtered and the filtrate was alkalized by adding aqueous sodium bicarbonate to the filtrate. After alkalinization, the mixture was extracted with chloroform. The organic layers were combined, dried with anhydrous sodium sulfate and filtered. The filtrate was concentrated under reduced pressure to give tert-butyl 4-aminopiperazine-1-carboxylate (730 mg, yield: 100%) as a light yellow oil.
References
[1] Patent: WO2007/46550, 2007, A1. Location in patent: Page/Page column 120
[2] Patent: WO2006/20561, 2006, A2. Location in patent: Page/Page column 61
[3] European Journal of Medicinal Chemistry, 2018, vol. 158, p. 247 - 258
1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE manufacturers
- Product
- tert-Butyl 4-aMinopiperazin-1-carboxylate 118753-66-5
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 1-TERT-BUTYLOXYCARBONYL-4-AMINO-PIPERAZINE 118753-66-5
- Price
- US $0.50/g
- Min. Order
- 1g
- Purity
- 98%min
- Supply Ability
- 10g,100g,1kg
- Release date
- 2020-01-10