4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester
- Product Name
- 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester
- CAS No.
- 203662-51-5
- Chemical Name
- 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester
- Synonyms
- tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate;1-Boc-4-allyl-4-hydroxypiperidine;4-Allyl-1-Boc-4-hydroxypiperidine;benzyl 4-allyl-4-hydroxypiperidine-1-carboxylate;1-(t-butoxycarbonyl)-4-(prop-2-enyl)-4-hydroxypiperidine;tert-butyl 4-hydroxy-4-(prop-2-en-1-yl)piperidine-1-carboxylate;tert-butyl 4-hydroxy-4-(prop-2-en-1-yl)piperidine-1-carboxyl...;4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester;1-Piperidinecarboxylic acid, 4-hydroxy-4-(2-propenyl)-, 1,1-diMethylethyl ester;1-Piperidinecarboxylic acid, 4-hydroxy-4-(2-propen-1-yl)-, 1,1-diMethylethyl ester
- CBNumber
- CB81501492
- Molecular Formula
- C13H23NO3
- Formula Weight
- 241.33
- MOL File
- 203662-51-5.mol
4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester Property
- Density
- 1.052
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- light yellow liquid
Safety
- RIDADR
- UN2811
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- PHB00143
- Product name
- 1-Boc-4-allyl-4-hydroxypiperidine
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $73.1
- Updated
- 2025/07/31
- Product number
- B810013
- Product name
- tert-Butyl4-Allyl-4-hydroxypiperidine-1-carboxylate
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- CS-M1451
- Product name
- 1-Piperidinecarboxylicacid,4-hydroxy-4-(2-propen-1-yl)-,1,1-dimethylethylester
- Packaging
- 1g
- Price
- $57
- Updated
- 2021/12/16
- Product number
- 4H56-1-218
- Product name
- 1-Boc-4-allyl-4-hydroxypiperidine
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 4113AH
- Product name
- tert-Butyl4-allyl-4-hydroxypiperidine-1-carboxylate
- Packaging
- 250mg
- Price
- $89
- Updated
- 2021/12/16
4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester Chemical Properties,Usage,Production
Synthesis
79099-07-3
106-95-6
203662-51-5
a. N-Boc-4-piperidone (50 g, 0.25 mol) and zinc powder (49.2 g, 0.75 mol) were suspended in a mixture of tetrahydrofuran (500 mL) and aqueous ammonium chloride (2/3, 500 mL) under nitrogen protection. The reaction temperature was controlled between -10 and 10 °C and 3-bromo-1-propene (109.3 g, 0.90 mol) was added slowly dropwise. After the dropwise addition, the temperature was slowly increased to 15-40 °C and the reaction was continued with stirring for 2-5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent ratio of petroleum ether/ethyl acetate = 2/1, v/v). Upon completion of the reaction, the reaction mixture was extracted with ethyl acetate (100 mL x 3). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain the crude product. The crude product was purified by silica gel column chromatography (eluent ratio of petroleum ether/ethyl acetate = 30/1 to 10/1, v/v) to afford the colorless oily target compound 4-allyl 1-Boc-4-hydroxypiperidine (60 g) in 99.9% yield.
References
[1] Patent: CN105440046, 2016, A. Location in patent: Paragraph 0006
[2] Patent: WO2010/58318, 2010, A1. Location in patent: Page/Page column 25-26
[3] Patent: WO2014/139144, 2014, A1. Location in patent: Page/Page column 165
[4] Patent: US2014/288081, 2014, A1. Location in patent: Paragraph 0667; 0668; 0669
[5] Patent: WO2014/139325, 2014, A1. Location in patent: Page/Page column 178; 179
4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester manufacturers
- Product
- 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester 203662-51-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-08