N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

Product Name: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
CAS No.: 406235-30-1
Chemical Name: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
Synonyms: EOS-61414;1-BOC-4-METHYL-PIPERIDIN-4-OL;1-boc-4-methyl-piperidine-4-ol;N-Boc-4-Hydroxy-4-methylpiperidine;1-Boc-4-hydroxy-4-methylpiperidine;N-BOC-4-METHYL-4-HYDROXY PIPERIDINE;4-HYDROXY-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylicacid,4-hydroxy-4-Methyl-,1,1-diMethylethylester;4-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl estercarboxylate
CBNumber: CB0668811
Molecular Formula: C11H21NO3
Formula Weight: 215.29
MOL File: 406235-30-1.mol

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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Property

Boiling point:: 296.4±33.0 °C(Predicted)
Density: 1.075±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 14.87±0.20(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C11H21NO3/c1-10(2,3)15-9(13)12-7-5-11(4,14)6-8-12/h14H,5-8H2,1-4H3
InChIKey: SWUCHJAQBNXPBO-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CCC(O)(C)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B704210
Product name: tert-butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B704210
Product name: tert-butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging: 100mg
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: Z3740
Product name: tert-Butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging: 1g
Price: $87
Updated: 2021/12/16

Matrix Scientific

Product number: 115346
Product name: tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate
Purity: 96%
Packaging: 100mg
Price: $215
Updated: 2021/12/16

Matrix Scientific

Product number: 115346
Product name: tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate
Purity: 96%
Packaging: 250mg
Price: $303
Updated: 2021/12/16

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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Chemical Properties,Usage,Production

Chemical Properties

White powder, stable at room temperature and pressure, avoid contact with strong oxidants.

Synthesis

75-16-1

79099-07-3

406235-30-1

a) N-Boc-4-piperidone (1.0 g, 5.0 mmol) was dissolved in anhydrous ether (10 mL) and cooled to -10°C under nitrogen protection. An ether solution of methylmagnesium bromide (3M, 2.5 mL, 7.5 mmol) was slowly added dropwise, and the reaction mixture was stirred for 5 minutes after the drop was completed. The cooling bath was removed and the reaction mixture was allowed to warm to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL) and subsequently diluted with water (20 mL) and ether (20 mL). The aqueous phase was separated and extracted with ether (2 x 30 mL), and the combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford N-BOC-4-methyl-4-hydroxypiperidine as a colorless oil (1.05 g, 97% yield).1H NMR (400 MHz, CDCl3) δ 3.76-3.64 (m, 2H), 3.29 -3.16 (m, 2H), 1.66 (s, 1H), 1.45 (s, 9H), 1.25 (s, 3H), solvent peaks were not clearly attributed.

References

[1] Journal of the American Chemical Society, 2013, vol. 135, # 41, p. 15342 - 15345
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 156
[3] Patent: WO2009/151598, 2009, A1. Location in patent: Page/Page column 148-149
[4] Patent: WO2014/164409, 2014, A1. Location in patent: Page/Page column 32; 33
[5] Patent: WO2014/164428, 2014, A1. Location in patent: Page/Page column 25

N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Suppliers

China 93 India 2 United Kingdom 3 United States 13 Global 111

Shanghai Hobor Chemical Co., Ltd

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View Lastest Price from N-BOC-4-METHYL-4-HYDROXY PIPERIDINE manufacturers

Career Henan Chemical Co

Product: N-BOC-4-METHYL-4-HYDROXY PIPERIDINE 406235-30-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2018-08-08

406235-30-1, N-BOC-4-METHYL-4-HYDROXY PIPERIDINERelated Search:

1-N-Boc-4-(Phenylamino)piperidine 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER N-BOC-4-METHYL-4-HYDROXY PIPERIDINE N-BOC-1-OXA-7-AZA-SPIRO[3.5]NONANE TERT-BUTYL6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[CHROMENE-2,4'-PIPERIDINE!-1'-CARBOXY TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE 6-ACETYLAMINO-4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 4'-HYDROXY-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL-1'-CARBOXYLIC ACID TERT-BUTYL ESTER 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic Acid tert-Butyl Ester 4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 6-ACETYLAMINO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL 1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one

N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

1-BOC-4-METHYL-PIPERIDIN-4-OL

4-HYDROXY-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

4-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl estercarboxylate

1-Boc-4-hydroxy-4-methylpiperidine

1-boc-4-methyl-piperidine-4-ol

1-Piperidinecarboxylicacid,4-hydroxy-4-Methyl-,1,1-diMethylethylester

EOS-61414

N-Boc-4-Hydroxy-4-methylpiperidine

406235-30-1