1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

Product Name: 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
CAS No.: 147804-30-6
Chemical Name: 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER
Synonyms: t-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate;N-Boc-1-oxa-6-azaspiro[2.5]octane;6-Boc-1-oxa-6-azaspiro[2.5]octane,97%;1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID;N-Boc-1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid;6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane;tert-Butyl 1-oxa-6-azaspiro[2.5]octan-6-carboxylate;6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester;1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester;2-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
CBNumber: CB5704293
Molecular Formula: C11H19NO3
Formula Weight: 213.27
MOL File: 147804-30-6.mol

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1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Property

Melting point:: 50-52℃
Boiling point:: 297.6±33.0 °C(Predicted)
Density: 1.12
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: -0.82±0.20(Predicted)
form: Crystalline Powder
color: White
InChI: InChI=1S/C11H19NO3/c1-10(2,3)15-9(13)12-6-4-11(5-7-12)8-14-11/h4-8H2,1-3H3
InChIKey: ULSBMKGFFFMGOI-UHFFFAOYSA-N
SMILES: O1C2(CCN(C(OC(C)(C)C)=O)CC2)C1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 22-26-36/37/39-45
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00064
Product name: 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
Purity: Aldrich
Packaging: 1g
Price: $403
Updated: 2025/07/31

TCI Chemical

Product number: B5501
Product name: tert-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate
Purity: >97.0%(GC)
Packaging: 1g
Price: $142
Updated: 2025/07/31

TCI Chemical

Product number: B5501
Product name: tert-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate
Purity: >97.0%(GC)
Packaging: 5g
Price: $423
Updated: 2025/07/31

TRC

Product number: O845605
Product name: 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
Packaging: 1g
Price: $60
Updated: 2021/12/16

TRC

Product number: O845605
Product name: 1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester
Packaging: 5g
Price: $140
Updated: 2021/12/16

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1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Chemical Properties,Usage,Production

Uses

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic Acid tert-Butyl Ester is used in the synthesis of a T-type Ca2+ channel antagonist, 4-Aminomethyl-4-fluoropiperidine.

Synthesis

79099-07-3

147804-30-6

General procedure for the synthesis of tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate from N-tert-butoxycarbonyl-4-piperidone: [Reference Example 1] Synthesis of tert-butyl 6-azaspiro[2.5]octane-6-carboxylate. 60% NaH-oil packet (5.28 g, 132 mmol) was suspended in dimethylsulfoxide (DMSO) (250 mL) and after cooling to 0°C, trimethylsulfonium iodide (29.0 g, 132 mmol) was added. The reaction mixture was warmed to room temperature and stirred for 40 min. Subsequently, N-Boc-4-piperidone (Boc = tert-butoxycarbonyl) (25.0 g, 125 mmol) was added and the reaction mixture was stirred at room temperature for 1 hr and then at 55 °C for 1.5 hrs. After completion of the reaction, the mixture was poured into ice-cooled water (500 mL) and extracted with ethyl acetate (AcOEt) (500 mL × 3 times). The ethyl acetate layers were combined, washed with water, then with saturated brine and finally dried with anhydrous Na2SO4. After filtration, the filtrate was concentrated to give tert-butyl 6-aza-1-oxaspiro[2.5]octane-6-carboxylate. The product was structurally confirmed by 1H-NMR. The yield was 26.4 g (99%).1H-NMR (270 MHz, CDCl3): δ 1.40-1.49 (m, 2H), 1.46 (s, 9H), 1.74-1.85 (m, 2H), 2.69 (s, 2H), 3.37-3.48 (m, 2H), 3.68-3.77 (m, 2H).

References

[1] Patent: EP1505067, 2005, A1. Location in patent: Page/Page column 368
[2] Patent: WO2008/10765, 2008, A1. Location in patent: Page/Page column 66-67
[3] Patent: US2010/4239, 2010, A1. Location in patent: Page/Page column 93
[4] Patent: WO2005/49620, 2005, A1. Location in patent: Page/Page column 24
[5] Patent: CN108727400, 2018, A. Location in patent: Paragraph 0115; 0118; 0120

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate 147804-30-6
Price: US $1.60-6.60/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-19

Career Henan Chemical Co

Product: 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 147804-30-6
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-25

147804-30-6, 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTERRelated Search:

1-oxa-6-azaspiro[3,4]octane-6-carboxylic acid tert-butyl ester tert-Butyl 2,5-Dioxa-8-aza-spiro[3,5]nonane-8-carboxylate tert-butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate tert-butyl 1-oxa-6-azaspiro[3.4]octane-6-carboxylate tert-Butyl 1-thia-6-azaspiro[3.3]heptane-6-carboxylate 1H-Pyrrolo[2,3-b]pyridine, 1-[(4-methylphenyl)sulfonyl]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)- methyl 1-methyl-2-oxocyclopentanecarboxylate tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Benzyl 3-(2-bromoethyl)azetidine-1-carboxylate (S)-tert-butyl 3-bromopyrrolidine-1-carboxylate 1-OXA-5-AZASPIRO[2.5]OCTANE-5-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER

1-Oxa-6-aza-spiro[2.5]octan-6-carboxylic acid tert-butyl ester

6-Aza-1-oxaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID

N-Boc-1-oxa-6-azaspiro[2.5]octane

tert-Butyl 1-oxa-6-azaspiro[2.5]octane-6-carboxylate, 6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane

1-oxa-6-aza-spiro-[2.5]octane-6-caboxylic acid tert-butyl ester

N-Boc-1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid

1-oxy-6-azaspiro[2.5]-octane-6-carboxylic acid, 1,1-dimethylethylester

2-oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester

6-Boc-1-oxa-6-azaspiro[2.5]octane,97%

t-Butyl 1-Oxa-6-azaspiro[2.5]octane-6-carboxylate

6-(tert-Butoxycarbonyl)-1-oxa-6-azaspiro[2.5]octane

1-oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethyle...

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid, 1,1-dimethylethyl ester (9CI, ACI)

1-Oxa-6-azaspiro[2.5]octane-6-carboxylic acid tert-butyl ester - [O1979]

tert-Butyl 1-oxa-6-azaspiro[2.5]octan-6-carboxylate

147804-30-6

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