tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate

Product Name: tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
CAS No.: 1420859-80-8
Chemical Name: tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate
Synonyms: 1-Boc-3-(2-bromoethyl)azetidine;tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate;3-(2-Bromo-ethyl)-azetidine-1-carboxylic acid tert-butyl ester;1-Azetidinecarboxylic acid, 3-(2-bromoethyl)-, 1,1-dimethylethyl ester
CBNumber: CB93052845
Molecular Formula: C10H18BrNO2
Formula Weight: 264.16
MOL File: 1420859-80-8.mol

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tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Property

Boiling point:: 298.1±13.0 °C(Predicted)
Density: 1.320±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
pka: -1.68±0.40(Predicted)
Appearance: Colorless to light yellow Liquid
InChI: InChI=1S/C10H18BrNO2/c1-10(2,3)14-9(13)12-6-8(7-12)4-5-11/h8H,4-7H2,1-3H3
InChIKey: IMCAWEYWTGJUEH-UHFFFAOYSA-N
SMILES: N1(C(OC(C)(C)C)=O)CC(CCBr)C1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B997030
Product name: tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
Packaging: 25mg
Price: $265
Updated: 2021/12/16

AK Scientific

Product number: 0108DV
Product name: Tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
Packaging: 100mg
Price: $856
Updated: 2021/12/16

AK Scientific

Product number: 0108DV
Product name: Tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
Packaging: 2.5g
Price: $2366
Updated: 2021/12/16

Chemenu

Product number: CM284027
Product name: tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
Purity: 95%
Packaging: 5g
Price: $1869
Updated: 2021/12/16

Crysdot

Product number: CD11260495
Product name: tert-Butyl3-(2-bromoethyl)azetidine-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $1980
Updated: 2021/12/16

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tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Chemical Properties,Usage,Production

Synthesis

152537-03-6

1420859-80-8

General procedure for the synthesis of tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate from tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate: To a solution of tert-butyl 3-(2-hydroxyethyl)azetidine-1-carboxylate (6.1 g, 30.3 mmol) in dichloromethane (100 mL) was added, in sequence, at 0 °C carbon tetrabromide (19.8 g 60.6 mmol) and triphenylphosphine (15.7 g, 60.6 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the mixture was concentrated and the residue was purified by silica gel column chromatography (eluent: petroleum ether/ethyl acetate=100:1) to afford tert-butyl 3-(2-bromoethyl)azetidine-1-carboxylate (5.5 g, 69.4% yield) as a colorless oil.LC-MS m/z: 208 [M+H-56].

References

[1] Patent: WO2017/27684, 2017, A1. Location in patent: Paragraph 00255

tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 3-(2-bromoethyl)azetidine-1-carboxylate Suppliers

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1420859-80-8