ChemicalBook > CAS DataBase List > N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

N-BOC-4-METHYL-4-HYDROXY PIPERIDINE

Product Name
N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
CAS No.
406235-30-1
Chemical Name
N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
Synonyms
EOS-61414;1-BOC-4-METHYL-PIPERIDIN-4-OL;1-boc-4-methyl-piperidine-4-ol;N-Boc-4-Hydroxy-4-methylpiperidine;1-Boc-4-hydroxy-4-methylpiperidine;N-BOC-4-METHYL-4-HYDROXY PIPERIDINE;4-HYDROXY-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperidinecarboxylicacid,4-hydroxy-4-Methyl-,1,1-diMethylethylester;4-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl estercarboxylate
CBNumber
CB0668811
Molecular Formula
C11H21NO3
Formula Weight
215.29
MOL File
406235-30-1.mol
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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Property

Boiling point:
296.4±33.0 °C(Predicted)
Density 
1.075±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
14.87±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C11H21NO3/c1-10(2,3)15-9(13)12-7-5-11(4,14)6-8-12/h14H,5-8H2,1-4H3
InChIKey
SWUCHJAQBNXPBO-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCC(O)(C)CC1
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B704210
Product name
tert-butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B704210
Product name
tert-butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging
100mg
Price
$155
Updated
2021/12/16
AK Scientific
Product number
Z3740
Product name
tert-Butyl4-hydroxy-4-methylpiperidine-1-carboxylate
Packaging
1g
Price
$87
Updated
2021/12/16
Matrix Scientific
Product number
115346
Product name
tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate
Purity
96%
Packaging
100mg
Price
$215
Updated
2021/12/16
Matrix Scientific
Product number
115346
Product name
tert-Butyl 4-hydroxy-4-methylpiperidine-1-carboxylate
Purity
96%
Packaging
250mg
Price
$303
Updated
2021/12/16
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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Chemical Properties,Usage,Production

Chemical Properties

White powder, stable at room temperature and pressure, avoid contact with strong oxidants.

Synthesis

75-16-1

79099-07-3

406235-30-1

a) N-Boc-4-piperidone (1.0 g, 5.0 mmol) was dissolved in anhydrous ether (10 mL) and cooled to -10°C under nitrogen protection. An ether solution of methylmagnesium bromide (3M, 2.5 mL, 7.5 mmol) was slowly added dropwise, and the reaction mixture was stirred for 5 minutes after the drop was completed. The cooling bath was removed and the reaction mixture was allowed to warm to room temperature and stirring was continued for 2 hours. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution (10 mL) and subsequently diluted with water (20 mL) and ether (20 mL). The aqueous phase was separated and extracted with ether (2 x 30 mL), and the combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford N-BOC-4-methyl-4-hydroxypiperidine as a colorless oil (1.05 g, 97% yield).1H NMR (400 MHz, CDCl3) δ 3.76-3.64 (m, 2H), 3.29 -3.16 (m, 2H), 1.66 (s, 1H), 1.45 (s, 9H), 1.25 (s, 3H), solvent peaks were not clearly attributed.

References

[1] Journal of the American Chemical Society, 2013, vol. 135, # 41, p. 15342 - 15345
[2] Patent: WO2014/128465, 2014, A1. Location in patent: Page/Page column 156
[3] Patent: WO2009/151598, 2009, A1. Location in patent: Page/Page column 148-149
[4] Patent: WO2014/164409, 2014, A1. Location in patent: Page/Page column 32; 33
[5] Patent: WO2014/164428, 2014, A1. Location in patent: Page/Page column 25

N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4-METHYL-4-HYDROXY PIPERIDINE Suppliers

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View Lastest Price from N-BOC-4-METHYL-4-HYDROXY PIPERIDINE manufacturers

Career Henan Chemical Co
Product
N-BOC-4-METHYL-4-HYDROXY PIPERIDINE 406235-30-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2018-08-08

406235-30-1, N-BOC-4-METHYL-4-HYDROXY PIPERIDINERelated Search:

1-N-Boc-4-(Phenylamino)piperidine 1-OXA-6-AZASPIRO[2.5]OCTANE-6-CARBOXYLIC ACID, 1,1-DIMETHYLETHYL ESTER N-BOC-4-METHYL-4-HYDROXY PIPERIDINE N-BOC-1-OXA-7-AZA-SPIRO[3.5]NONANE TERT-BUTYL6-BROMO-4-OXO-3,4-DIHYDRO-1'H-SPIRO[CHROMENE-2,4'-PIPERIDINE!-1'-CARBOXY TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE 6-ACETYLAMINO-4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 4'-HYDROXY-3',4',5',6'-TETRAHYDRO-2'H-[2,4']BIPYRIDINYL-1'-CARBOXYLIC ACID TERT-BUTYL ESTER 4-Hydroxy-4-(1H-imidazol-4-yl)piperidine-1-carboxylic acid tert-butyl ester 4-Hydroxy-4-(3-methylsulfanylphenyl)-piperidin-1-carboxylic Acid tert-Butyl Ester 4-OXO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 6-ACETYLAMINO-2-SPIRO(N-BOC-PIPERIDINE-4-YL)-BENZOPYRAN 4-Hydroxy-4-(2-propenyl)piperidine-1-carboxylic acid tert-butyl ester 1-BOC-4-HYDROXY-4-PIPERIDINECARBOXYLIC ACID 1-BOC-4-(4-BROMO-PHENYL)-PIPERIDIN-4-OL 1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL 1’-t-Butoxycarbonyl-5-hydroxy-spiro[chroman-2,4’-piperidin]-4-one

  • N-BOC-4-METHYL-4-HYDROXY PIPERIDINE
  • 1-BOC-4-METHYL-PIPERIDIN-4-OL
  • 4-HYDROXY-4-METHYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-Hydroxy-4-methylpiperidine-1-carboxylic acid tert-butyl estercarboxylate
  • 1-Boc-4-hydroxy-4-methylpiperidine
  • 1-boc-4-methyl-piperidine-4-ol
  • 1-Piperidinecarboxylicacid,4-hydroxy-4-Methyl-,1,1-diMethylethylester
  • EOS-61414
  • N-Boc-4-Hydroxy-4-methylpiperidine
  • 406235-30-1