N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL

Product Name: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL
CAS No.: 240401-09-6
Chemical Name: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL
Synonyms: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL;8-Boc-3-hydroxy-1-oxa-8-azaspiro[4.5]decane;benzyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxyla...;tert-butyl (3RS)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate;3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester - [H6090];1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester
CBNumber: CB61118878
Molecular Formula: C13H23NO4
Formula Weight: 257.33
MOL File: 240401-09-6.mol

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N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL Property

Boiling point:: 391.0±42.0 °C(Predicted)
Density: 1.16
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 14.34±0.20(Predicted)
Appearance: White to yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC

Product number: B699403
Product name: tert-Butyl3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B699403
Product name: tert-Butyl3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

TRC

Product number: B699403
Product name: tert-Butyl3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Synthonix

Product number: H6090
Product name: 3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylicacidtert-butylester
Purity: 97.0%
Packaging: 1g
Price: $80
Updated: 2021/12/16

AK Scientific

Product number: Y8395
Product name: 3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylicacidtert-butylester
Packaging: 250mg
Price: $84
Updated: 2021/12/16

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N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL Chemical Properties,Usage,Production

Synthesis

954236-44-3

240401-09-6

The general procedure for the synthesis of tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate from tert-butyl 3-oxa-8-azaspiro[4.5]decane-8-carboxylate is as follows: sodium borohydride (445 mg, 11.8 mmol) was added to 3-oxo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate at 0 °C in a tert-butyl ester (1.50 g, 5.88 mmol) in a methanolic solution (59 mL). The reaction mixture was stirred at 23 °C for 2 hours. Upon completion of the reaction, the solvent was removed by vacuum and the residue was partitioned between ethyl acetate and water. The aqueous layer was extracted with ethyl acetate and the combined organic layers were dried with magnesium sulfate, filtered and concentrated under reduced pressure to give a mixture of C74 and C75 as a colorless oil. The yield of the racemic product was 1.45 g (5.63 mmol, 96%).GCMS m/z 257.1 [M+].1H NMR (400 MHz, CDCl3) δ 4.54-4.48 (br m, 1H), 3.93 (dd, half of the ABX mode, J = 10.2, 4.3 Hz, 1H), 3.85-3.79 (m, 1H), 3.67-3.79 (m, 1H). 1H), 3.67-3.53 (br m, 2H), 3.40-3.28 (m, 2H), 1.97 (dd, half of ABX mode, J = 13.7, 6.2 Hz, 1H), 1.89-1.48 (m, 6H, hypothetical; partially obscured by water peaks), 1.46 (s, 9H). A portion of the racemate (1.30 g, 5.05 mmol) was separated into its component enantiomers by supercritical fluid chromatography [column: Phenomenex Lux Amylose-1,5 μm; mobile phase: 85:15 carbon dioxide/(methanol containing 0.2% ammonium hydroxide)]. The first elution product showed a negative (-) rotation and was in the form of a dendritic resin, named C74, with a yield of 650 mg (2.53 mmol, 50%). The second elution product exhibits a positive (+) rotation, is solid, named C75, and yields 620 mg (2.41 mmol, 48%).The absolute stereochemistry of C74 and C75 was determined based on the conversion of C74 to C72 (see Step 4).

References

[1] Patent: US2018/208607, 2018, A1. Location in patent: Paragraph 0226; 0384; 0400-0402
[2] Patent: US2018/208608, 2018, A1. Location in patent: Paragraph 0322; 0339
[3] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 21, p. 6545 - 6553

N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL Suppliers

China 65 India 3 United States 15 Global 83

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View Lastest Price from N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL manufacturers

Career Henan Chemical Co

Product: N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL 240401-09-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200kg
Release date: 2020-01-02

240401-09-6, N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL Related Search:

1,1-Dimethylethyl 1-oxa-8-azaspiro[4.5]decane-8-carboxylate 1-Oxa-8-azaspiro[4.5]decane N-BOC-4-METHYL-4-HYDROXY PIPERIDINE TERT-BUTYL 4-(3-HYDROXYPROPYL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL

N-BOC-1-OXA-8-AZA-SPIRO[4.5]DECAN-3-OL

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

1-Oxa-8-azaspiro[4.5]decane-8-carboxylic acid, 3-hydroxy-, 1,1-diMethylethyl ester

8-Boc-3-hydroxy-1-oxa-8-azaspiro[4.5]decane

benzyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl 3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxyla...

tert-butyl (3RS)-3-hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

3-Hydroxy-1-oxa-8-azaspiro[4.5]decane-8-carboxylic acid tert-butyl ester - [H6090]

240401-09-6