METHYL-4-IODO-3-HYDROXY BENZOATE
- Product Name
- METHYL-4-IODO-3-HYDROXY BENZOATE
- CAS No.
- 157942-12-6
- Chemical Name
- METHYL-4-IODO-3-HYDROXY BENZOATE
- Synonyms
- RARECHEM AL BF 0964;Lifitegrast Impurity 93;Propanoylchloride,6-ethoxy-;Methyl 3-hydroxy-4-iodobenzoate;METHYL-3-HYDROY-4-IODO BENZOATE;METHYL-4-IODO-3-HYDROXY BENZOATE;3-hydroxy-4-iodobenzenecarboxylate;Methyl3-hydroxy-4-iodobenzoate,97%;Methyl 3-hydroxy-4-iodobenzenecarboxylate;3-Hydroxy-4-iodo-benzoic acid methyl ester
- CBNumber
- CB3412190
- Molecular Formula
- C8H7IO3
- Formula Weight
- 278.04
- MOL File
- 157942-12-6.mol
METHYL-4-IODO-3-HYDROXY BENZOATE Property
- Melting point:
- 53-54°
- Boiling point:
- 299.3±25.0 °C(Predicted)
- Density
- 1.880±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- Solid
- pka
- 7.70±0.10(Predicted)
- Appearance
- Off-white to light brown Solid
- Water Solubility
- Slightly soluble in water.
- Sensitive
- Light Sensitive
Safety
- HazardClass
- IRRITANT
- HS Code
- 2918290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- M323533
- Product name
- Methyl3-hydroxy-4-iodobenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M323533
- Product name
- Methyl3-hydroxy-4-iodobenzoate
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 2629-H-09
- Product name
- Methyl 3-hydroxy-4-iodobenzoate
- Packaging
- 5G
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 048709
- Product name
- Methyl 3-hydroxy-4-iodobenzenecarboxylate
- Purity
- 95+%
- Packaging
- 1g
- Price
- $29
- Updated
- 2021/12/16
- Product number
- 048709
- Product name
- Methyl 3-hydroxy-4-iodobenzenecarboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $89
- Updated
- 2021/12/16
METHYL-4-IODO-3-HYDROXY BENZOATE Chemical Properties,Usage,Production
Uses
Useful intermediate for pharmaceutical and organic synthesis.
Synthesis Reference(s)
The Journal of Organic Chemistry, 68, p. 9423, 2003 DOI: 10.1021/jo0350763
Synthesis
67-56-1
58123-77-6
157942-12-6
The general procedure for the synthesis of methyl 3-hydroxy-4-iodobenzoate from methanol and 3-hydroxy-4-iodobenzoic acid was as follows: first, 61.31 g of 3-hydroxy-4-iodobenzoic acid was obtained, which presented as a white solid. Subsequently, 47 g (150 mmol) of 3-hydroxy-4-iodobenzoic acid was dissolved in 300 mL of methanol and 6.13 g (35.6 mmol) of p-toluenesulfonic acid was added as a catalyst. The reaction mixture was heated continuously at 70 °C for 48 hours. Upon completion of the reaction, the reaction was terminated by adding 11 μL of water. The precipitated product was filtered and washed with distilled water to neutral pH. finally, 37.4 g (76% yield) of methyl 3-hydroxy-4-iodobenzoate was obtained as a beige powder.
References
[1] Chemical Communications (Cambridge, United Kingdom), 2012, vol. 48, # 83, p. 10328 - 10330,3
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 9, p. 1103 - 1114
[3] Patent: US2009/12129, 2009, A1. Location in patent: Page/Page column 21
[4] Patent: US2003/232853, 2003, A1. Location in patent: Page 38
[5] Patent: WO2006/18325, 2006, A1. Location in patent: Page/Page column 26
METHYL-4-IODO-3-HYDROXY BENZOATE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from METHYL-4-IODO-3-HYDROXY BENZOATE manufacturers
- Product
- METHYL-4-IODO-3-HYDROXY BENZOATE 157942-12-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-07-02