4-BETA-HYDROXYCHOLESTEROL
- Product Name
- 4-BETA-HYDROXYCHOLESTEROL
- CAS No.
- 17320-10-4
- Chemical Name
- 4-BETA-HYDROXYCHOLESTEROL
- Synonyms
- 4-Hydroxy Cholesterol;4--Hydroxy Cholestrol;cholest-5-ene-3,4-diol;4β-Hydroxy Cholesterol;Cholesterol Impurity 30;5-CHOLESTEN-3β, 4β-DIOL;4-BETA-HYDROXYCHOLESTEROL;4β-Hydroxycholesterol-[d4];4β-Hydroxycholesterol-[d5];2H4]-4β-Hydroxycholesterol
- CBNumber
- CB3417069
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 17320-10-4.mol
4-BETA-HYDROXYCHOLESTEROL Property
- Melting point:
- 172-174°C
- Boiling point:
- 500.2±30.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 14.32±0.70(Predicted)
- color
- White to Pale Beige
Safety
- HS Code
- 9999999999
N-Bromosuccinimide Price
- Product number
- R208795
- Product name
- CHOLEST-5-ENE-3-BETA,4-BETA-DIOL
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $283
- Updated
- 2024/03/01
4-BETA-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
Definition
ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in he human circulation.
Biological Activity
4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].
References
[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43.
4-BETA-HYDROXYCHOLESTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
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