4-BETA-HYDROXYCHOLESTEROL
- Product Name
- 4-BETA-HYDROXYCHOLESTEROL
- CAS No.
- 17320-10-4
- Chemical Name
- 4-BETA-HYDROXYCHOLESTEROL
- Synonyms
- 4-Hydroxy Cholesterol;4--Hydroxy Cholestrol;cholest-5-ene-3,4-diol;4β-Hydroxy Cholesterol;Cholesterol Impurity 30;5-CHOLESTEN-3β, 4β-DIOL;4-BETA-HYDROXYCHOLESTEROL;4β-Hydroxycholesterol-[d4];4β-Hydroxycholesterol-[d5];2H4]-4β-Hydroxycholesterol
- CBNumber
- CB3417069
- Molecular Formula
- C27H46O2
- Formula Weight
- 402.65
- MOL File
- 17320-10-4.mol
4-BETA-HYDROXYCHOLESTEROL Property
- Melting point:
- 172-174°C
- Boiling point:
- 500.2±30.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- Chloroform (Slightly), Ethyl Acetate (Slightly)
- form
- Solid
- pka
- 14.32±0.70(Predicted)
- color
- White to Pale Beige
Safety
- HS Code
- 9999999999
N-Bromosuccinimide Price
- Product number
- R208795
- Product name
- CHOLEST-5-ENE-3-BETA,4-BETA-DIOL
- Purity
- AldrichCPR
- Packaging
- 1MG
- Price
- $29.8
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $77
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $142
- Updated
- 2024/03/01
- Product number
- 19518
- Product name
- 4β-hydroxy Cholesterol
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $283
- Updated
- 2024/03/01
4-BETA-HYDROXYCHOLESTEROL Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A metabolite of Cholesterol. It is formed from Cholesterol by the drug-metabolizing enzyme cytochrome P 450 3A4. A potential ligand for the nuclear receptor LXR and also a new endogenous CYP3A marker.
Definition
ChEBI: A oxysterol that is cholesterol in which the hydrogen at the 4beta position has been replaced by a hydroxy group. A metabolite of cholesterol formed by the drug-metabolizing enzyme cytochrome P450 3A4, it is one of the major oxysterols in he human circulation.
Biological Activity
4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].cytochome p450 3a4 (cyp3a4) and cyp3a5 are important drug-metabolizing enzymes that oxidize small foreign organic molecules, such as toxins or drugs, and remove them from the body. they exhibit a large variation in hepatic expression and biological activity between different individuals. patients treated with drugs known to be strong inducers of cyp3a4/5 have highly elevated levels of 4β-hydroxycholesterol in the circulation [1].4β-hydroxy cholesterol, an endogenous oxysterol found in human circulation, is formed from cholesterol by cytochrome p450 (cyp) 3a4 and cyp3a5. in 12 different occasions during a 3-month period, the cvs for 4β-hydroxycholesterol ranged from 4.8 to 13.2% with an average cv of 7.1% at an average concentration of 30.8 ng/ml. in 24 volunteers treated with rifampicin, a strong cyp3a4/5 inducer, 4β-hydroxycholesterol increased in a dose-dependent way, while the isomer 4α-hydroycholesterol was not influenced by rifampicin treatment. these results suggested that 4β-hydroxy cholesterol is an endogenous marker for cyp3a4/5 activity [1].
References
[1]. diczfalusy u, kanebratt kp, bredberg e, et al. 4beta-hydroxycholesterol as an endogenous marker for cyp3a4/5 activity. stability and half-life of elimination after induction with rifampicin. br j clin pharmacol. 2009 jan;67(1):38-43.
4-BETA-HYDROXYCHOLESTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
4-BETA-HYDROXYCHOLESTEROL Suppliers
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18042
- Advantage
- 56
- Tel
- 86-021-61559134 15921386130
- Fax
- 021-55068248
- 3423497944@qq.com
- Country
- China
- ProdList
- 8144
- Advantage
- 55
- Tel
- 022-6537-8550 15522853686
- Fax
- 022-2532-9655
- sales@altasci.com.cn
- Country
- China
- ProdList
- 4511
- Advantage
- 55
- Tel
- 18607101326 15172504745
- Fax
- +86-27-84254680
- aileen@chemfaces.com
- Country
- China
- ProdList
- 7057
- Advantage
- 55
- Tel
- 18620099427
- Fax
- +86-20-62619665
- amy@howeipharm.com
- Country
- China
- ProdList
- 17687
- Advantage
- 55
- Tel
- 400-1166-196 18502815961
- Fax
- QQ：800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 14603
- Advantage
- 60
- Tel
- 021-61847300 13341622919
- Fax
- 021-61847300
- shcss01@163.com
- Country
- China
- ProdList
- 4808
- Advantage
- 58
- Tel
- 025-66028182 18112977050
- Fax
- (3)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 15818
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52693
- Advantage
- 58
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Country
- China
- ProdList
- 57412
- Advantage
- 58
- Tel
- 18616526224
- lianshuo@vip.126.com
- Country
- China
- ProdList
- 9607
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 021-52961053 13524666654
- 3004902811@qq.com
- Country
- China
- ProdList
- 9724
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- info@synzest.com
- Country
- China
- ProdList
- 9286
- Advantage
- 58
- Tel
- 021-58432009 400-005-6266
- Fax
- 021-58436166
- marketing1@energy-chemical.com
- Country
- China
- ProdList
- 44808
- Advantage
- 58
- Tel
- 020-020-3846236 17688849268
- 2443244976@qq.com
- Country
- China
- ProdList
- 7775
- Advantage
- 58
- Tel
- 18018507602 15900573766
- 394643792@qq.com
- Country
- China
- ProdList
- 3025
- Advantage
- 58
- Tel
- 18351873721
- helen.zhang@synzest.com
- Country
- China
- ProdList
- 8295
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 17717235263
- cindy.yang@lgcgroup.com
- Country
- China
- ProdList
- 15583
- Advantage
- 58
- Tel
- 18113192475 18113192475
- 3157321941@qq.com
- Country
- China
- ProdList
- 5001
- Advantage
- 58
- Tel
- 021-58000709 15900491054
- info@scrbio.com
- Country
- China
- ProdList
- 10329
- Advantage
- 58
- Tel
- 021-34675735 19147740836
- 1986399151@qq.com
- Country
- China
- ProdList
- 9844
- Advantage
- 58
- Tel
- 021-67187366 19901745723
- info@bwtlab.com
- Country
- China
- ProdList
- 9268
- Advantage
- 58
- Tel
- 400-1107768 15058188853
- Fax
- 0571-88150696
- 478133536@qq.com
- Country
- China
- ProdList
- 8552
- Advantage
- 58
- Tel
- 18162595016; 18162595016
- 3287908757@qq.com
- Country
- China
- ProdList
- 10335
- Advantage
- 58
- Tel
- 17301488900
- Fax
- 025-85560043
- judy.xia@synzest.com
- Country
- China
- ProdList
- 12582
- Advantage
- 58
- Tel
- 18616537568
- hanfangpharma@126.com
- Country
- China
- ProdList
- 30961
- Advantage
- 58
- Tel
- 18162791556
- 3152548389@qq.com
- Country
- China
- ProdList
- 4351
- Advantage
- 58
- Tel
- 15102117276 19921389125
- tech@zzbioco.com
- Country
- China
- ProdList
- 12065
- Advantage
- 58
- Tel
- 028-87865381 18108190480
- 2881944542@qq.com
- Country
- China
- ProdList
- 3302
- Advantage
- 58
- Tel
- 18017610038
- zheyansh@163.com
- Country
- CHINA
- ProdList
- 3619
- Advantage
- 58
- Tel
- --
- Fax
- --
- info@zzsrm.com
- Country
- CHINA
- ProdList
- 6650
- Advantage
- 58
- Tel
- --
- Fax
- --
- shqcsw01@163.com
- Country
- CHINA
- ProdList
- 6367
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6179
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6890
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6266
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6969
- Advantage
- 58
- Tel
- --
- Fax
- --
- 15810802415@139.com
- Country
- CHINA
- ProdList
- 6750
- Advantage
- 58
- Tel
- --
- Fax
- --
- yanjinbio@163.com
- Country
- CHINA
- ProdList
- 6896
- Advantage
- 58
- Tel
- --
- Fax
- --
- chenxue_gz@163.com
- Country
- CHINA
- ProdList
- 6600
- Advantage
- 58
- Tel
- --
- Fax
- --
- lyn@biopike.com.cn
- Country
- CHINA
- ProdList
- 6629
- Advantage
- 58
- Tel
- --
- Fax
- --
- shlmai@163.com
- Country
- CHINA
- ProdList
- 6699
- Advantage
- 58
- Tel
- --
- Fax
- --
- shzeysw@163.com
- Country
- CHINA
- ProdList
- 6549
- Advantage
- 58
- Tel
- --
- Fax
- --
- Country
- CHINA
- ProdList
- 6973
- Advantage
- 58
- Tel
- --
- Fax
- --
- sales@wheybio.com
- Country
- CHINA
- ProdList
- 4398
- Advantage
- 58
- Tel
- --
- Fax
- --
- 1562893815@qq.com
- Country
- CHINA
- ProdList
- 6936
- Advantage
- 58