ML298

Product Name: ML298
CAS No.: 1426916-02-0
Chemical Name: ML298
Synonyms: ML298;CID53393915;ML298 >=98% (HPLC);ML-298, 10 mM in DMSO;ML-298,Inhibitor,ML 298,Phospholipase,inhibit;3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide;Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-
CBNumber: CB34199383
Molecular Formula: C22H23F3N4O2
Formula Weight: 432.44
MOL File: 1426916-02-0.mol

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ML298 Property

storage temp.: 2-8°C
solubility: DMF: 10 mg/ml; DMSO: 20 mg/ml; Ethanol: 1 mg/ml
form: powder
color: white to beige
InChI: 1S/C22H23F3N4O2/c23-16-2-1-3-17(13-16)29-14-27-21(31)22(29)6-9-28(10-7-22)11-8-26-20(30)15-4-5-18(24)19(25)12-15/h1-5,12-13H,6-11,14H2,(H,26,30)(H,27,31)
InChIKey: XAPVAKKLQGLNOY-UHFFFAOYSA-N
SMILES: Fc1c(ccc(c1)C(=O)NCCN2CCC3(N(CNC3=O)c4cc(ccc4)F)CC2)F

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1077
Product name: ML298
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $113
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML1077
Product name: ML298
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $356
Updated: 2026/03/19

Cayman Chemical

Product number: 15349
Product name: ML-298
Purity: ≥98%
Packaging: 1mg
Price: $40
Updated: 2024/03/01

Cayman Chemical

Product number: 15349
Product name: ML-298
Purity: ≥98%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 15349
Product name: ML-298
Purity: ≥98%
Packaging: 10mg
Price: $195
Updated: 2024/03/01

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ML298 Chemical Properties,Usage,Production

Description

ML-298 is an inhibitor of phospholipase D₂ (PLD₂; IC₅₀ = 355 nM). It is selective for PLD₂ over PLD₁ (IC₅₀ = 20,000 nM). It decreases invasive migration of U87-MG glioblastoma cells when used at a concentration of 10 μM without inducing cytotoxicity.

Uses

ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2).

Biochem/physiol Actions

ML298 is a potent, specific inhibitor of Phospholipase D2 (PLD2; IC50 = 355 nM). ML298 does not affect PLD1 activity at concentrations up to 20 μM.

References

[1] MATTHEW C. O’REILLY. Development of Dual PLD1/2 and PLD2 Selective Inhibitors from a Common 1,3,8-Triazaspiro[4.5]decane Core: Discovery of ML298 and ML299 That Decrease Invasive Migration in U87-MG Glioblastoma Cells[J]. Journal of Medicinal Chemistry, 2013, 56 6: 2695-2699. DOI: 10.1021/jm301782e

ML298 Preparation Products And Raw materials

Raw materials

Preparation Products

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ML298 Suppliers

China 39 United Kingdom 1 United States 6 Global 46

Sigma-Aldrich

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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1426916-02-0, ML298Related Search:

ML298

Benzamide, 3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-

ML298 >=98% (HPLC)

CID53393915

ML-298,Inhibitor,ML 298,Phospholipase,inhibit

3,4-difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-benzamide

ML-298, 10 mM in DMSO

1426916-02-0