9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER

Product Name: 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER
CAS No.: 37497-47-5
Chemical Name: 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER
Synonyms: RJXVYMMSQBYEHN-LVXZDWGESA-N;PROSTAGLANDIN E2-1-GLYCERYL ESTER;9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER;Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, 2,3-dihydroxypropyl ester, (5Z,11α,13E,15S)-
CBNumber: CB3422395
Molecular Formula: C23H38O7
Formula Weight: 426.54
MOL File: 37497-47-5.mol

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Property

solubility: DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 100 μg/ml

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 10140
Product name: Prostaglandin E2-1-glyceryl ester
Purity: ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters)
Packaging: 1mg
Price: $89
Updated: 2024/03/01

Cayman Chemical

Product number: 10140
Product name: Prostaglandin E2-1-glyceryl ester
Purity: ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters)
Packaging: 5mg
Price: $395
Updated: 2024/03/01

Cayman Chemical

Product number: 10140
Product name: Prostaglandin E2-1-glyceryl ester
Purity: ≥98% (as a 85:15 mixture of the 1- and 2-glyceryl esters)
Packaging: 10mg
Price: $700
Updated: 2024/03/01

American Custom Chemicals Corporation

Product number: LIP0003240
Product name: 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID-2,3-DIHYDROXYPROPYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $504.54
Updated: 2021/12/16

AK Scientific

Product number: 1580AH
Product name: 9-oxo-11alpha,15S-Dihydroxy-prosta-5Z,13E-dien-1-oicacid,2,3-dihydroxypropylester
Packaging: 5mg
Price: $537
Updated: 2021/12/16

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Chemical Properties,Usage,Production

Description

2-Arachidonoyl glycerol (2-AG; ) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB₁ receptor.^1,2 Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H₂ (PGH₂) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.³ The biosynthesis of PGH, PGD, PGE, PGF, and Thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.⁴

Definition

ChEBI: Prostaglandin E2 1-glyceryl ester is a 1-monoglyceride resulting from the condensation of the carboxy group of prostaglandin E2 with the 1-hydroxy group of glycerol. It has a role as a human metabolite. It is a 1-monoglyceride, an alicyclic ketone, a prostaglandins E, a tetrol and a secondary allylic alcohol. It is functionally related to a prostaglandin E2.

References

1. Sugiura, T., Kodaka, T., Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca²⁺ in neuroblastoma X glioma hybrid NG108-15 cells Biochem. Biophys. Res. Commun. 229,58-64(1996).
2. Sugiura, T., Kodaka, T., Kondo, S., et al. Is the cannabinoid CB₁ receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca²⁺ transient in NG108-15 cells J. Biochem. 122(4),890-895(1997).
3. Kozak, K.R., Crews, B.C., Morrow, J.D., et al. Metabolism of the endocannabinoids, 2-arachidonylgycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides J. Biol. Chem. 277(47),44877-44885(2002).
4. Kozak, K.R., Crews, B.C., Ray, J.L., et al. Metabolism of prostaglandin glycerol esters and prostaglandin ethanolamides in vitro and in vivo J. Biol. Chem. 276(40),36993-36998(2001).

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER Suppliers

China 14 United States 1 Global 15

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37497-47-5, 9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTERRelated Search:

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER 11-DEOXY PROSTAGLANDIN E2 Prostaglandin E2 PROSTAGLANDINS E2 METHYL ESTER

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, 2,3-DIHYDROXYPROPYL ESTER

RJXVYMMSQBYEHN-LVXZDWGESA-N

PROSTAGLANDIN E2-1-GLYCERYL ESTER

Prosta-5,13-dien-1-oic acid, 11,15-dihydroxy-9-oxo-, 2,3-dihydroxypropyl ester, (5Z,11α,13E,15S)-

37497-47-5