PROSTAGLANDINS E2 METHYL ESTER Property

storage temp. 

−20°C

solubility 

DMF: >25 mg/ml; DMSO: >30 mg/ml; Ethanol: >50 mg/ml; PBS pH 7.2: >150 μg/ml

Safety

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36/37/38

Safety Statements 

16-26-36

RIDADR 

UN 1231 3/PG 2

WGK Germany 

3

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H302Harmful if swallowed

H319Causes serious eye irritation

H336May cause drowsiness or dizziness

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

PROSTAGLANDINS E2 METHYL ESTER Chemical Properties,Usage,Production

Description

Prostaglandin E₂ methyl ester (PGE₂ methyl ester) is an analog of PGE₂ with enhanced lipid solubility. PGE₂ is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE₂ are transduced by at least four distinct receptors designated EP₁, EP₂, EP₃, and EP₄. Affinity constants (K_d) values of PGE₂ for these receptors range from 1-10 nM depending on the receptor subtype and tissue.