9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, (4-BENZOYLAMINO) PHENYL ESTER Property

solubility 

DMF: 65 mg/ml; DMSO: 28 mg/ml; Ethanol: 6 mg/ml; PBS pH 7.2: <125 μg/ml

form 

A crystalline solid

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

9-OXO-11ALPHA,15S-DIHYDROXY-PROSTA-5Z,13E-DIEN-1-OIC ACID, (4-BENZOYLAMINO) PHENYL ESTER Chemical Properties,Usage,Production

Description

PGE₂ p-benzamidophenyl ester is a crystalline derivative of PGE₂. PGE₂ is one of the primary COX products of arachidonic acid and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.^1,2,3,4 The effects of PGE₂ are transduced by at least four distinct receptors designated EP₁, EP₂, EP₃, and EP₄.⁵ Affinity constants (K_d) of PGE₂ for these receptors range from 1-10 nM depending on the receptor subtype and tissue.

Definition

ChEBI: Prostaglandin E2 p-benzamidophenyl ester is a prostanoid.

References

1. Willis, A.L., and Cornelsen, M. Repeated injection of prostaglandin E₂ in rat paws induces chronic swelling and a marked decrease in pain threshold Prostaglandins 3(3),353-357(1973).
2. Jackson, G.M., Sharp, H.T., and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E₂ gel versus low-dose oxytocin Am. J. Obstet. Gynecol. 171(4),1092-1096(1994).
3. Robert, A., Schultz, J.R., Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE₂, 15-methyl PGE₂, and 16,16-dimethyl PGE₂. Intravenous, oral and intrajejunal administration Gastroenterology 70(3),359-370(1976).
4. Arvind, P., Papavassiliou, E.D., Tsioulias, G.J., et al. Prostaglandin E₂ down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines Biochemistry 34(16),5604-5609(1995).
5. Coleman, R.A., Smith, W.L., and Narumiya, S. International Union of Pharmacology classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes Pharmacol. Rev. 46(2),205-229(1994).