Imidazolidinyl urea

Product Name: Imidazolidinyl urea
CAS No.: 39236-46-9
Chemical Name: Imidazolidinyl urea
Synonyms: IMIDAZOLIDINYL UREA;IMIDUREA;Sept 115;germall115;Tristat 1U;Euxyl K 200;Biopure 100;Imidurea NF;Unicide U-13;Imidazolidinyl
CBNumber: CB3426267
Molecular Formula: C11H16N8O8
Formula Weight: 388.29
MOL File: 39236-46-9.mol

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Imidazolidinyl urea Property

Melting point:: 141-143℃
Boiling point:: 514.04°C (rough estimate)
Density: 1.4245 (rough estimate)
vapor pressure: 0Pa at 25℃
refractive index: 1.6910 (estimate)
storage temp.: 2-8°C
solubility: Soluble in water and in glycerol, but insoluble in almost all organic solvents.
pka: 7.41±0.10(Predicted)
form: Liquid
color: Clear
Water Solubility: soluble
Merck: 14,4916
Stability:: Stable.
InChIKey: ZCTXEAQXZGPWFG-UHFFFAOYSA-N
LogP: 0.9 at 20℃
CAS DataBase Reference: 39236-46-9(CAS DataBase Reference)
EPA Substance Registry System: Imidurea (39236-46-9)

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26-36
WGK Germany: 2
RTECS: YT7365000
TSCA: Yes
HS Code: 29332990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H317May cause an allergic skin reaction
Precautionary statements: P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I5133
Product name: Imidazolidinyl urea
Packaging: 25g
Price: $51
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1336806
Product name: Imidurea
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $310.2
Updated: 2024/03/01

TCI Chemical

Product number: I0665
Product name: Imidazolidinyl Urea
Purity: >90.0%(N)
Packaging: 25g
Price: $30
Updated: 2024/03/01

TCI Chemical

Product number: I0665
Product name: Imidazolidinyl Urea
Purity: >90.0%(N)
Packaging: 250g
Price: $171
Updated: 2024/03/01

Alfa Aesar

Product number: H60729
Product name: Imidazolidinyl urea
Packaging: 25g
Price: $28.65
Updated: 2024/03/01

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Imidazolidinyl urea Chemical Properties,Usage,Production

Chemical Properties

Imidazolidinyl urea is a stable white, free-flowing odorless powder with a mild odour. It does not absorb ultraviolet light, and decomposes at temperatures above 160°C (Sheppard and Wilson, 1974). In aqueous solution the pH is close to neutrality. It is mainly contained in cosmetics and liquid soaps.

Uses

imidazolidinyl urea is one of the most commonly used anti-bacterial preservatives given its low sensitizing potential. In 2010, it was the tenth most frequently used preservative in the united States (parabens ranged from first to sixth place). generally, imidazolidinyl urea is not used alone but as a copreservative with parabens for broad-spectrum activity. Although it may yield low levels of formaldehyde when subjected to destructive methods-such as exposure to high temperatures-under normal use conditions, there is no detection of free formaldehyde release. of all the formaldehydereleasing preservatives, imidazolidinyl urea is the one least likely to cause skin sensitization and allergic reactions.

Definition

ChEBI: Imidazolidinyl urea is a member of ureas. It has a role as an antimicrobial agent. It is an antimicrobial preservative used in cosmetics. It acts as a formaldehyde releaser.

Production Methods

Imidurea is produced by the condensation of allantoin with formaldehyde.

General Description

Imidazolidinyl Urea is a non-aromatic, polar, hydrophilic antimicrobial compound. It is used as a preservative in a variety of applications, most notably in personal care products and cosmetics. It is effective against a broad spectrum of bacteria, fungi and yeast. It is used as a preservative in cosmetics, shampoos, deodorants, body lotions, and in some therapeutic topical ointments and creams.

Flammability and Explosibility

Non flammable

Pharmaceutical Applications

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is a broad-spectrum antimicrobial preservative used in cosmetics and topical pharmaceutical formulations; typical concentrations used are 0.03–0.5% w/w. It is effective between pH 3–9 and is reported to have synergistic effects when used with parabens.

Contact allergens

Imidazolidinyl urea, a formaldehyde releaser related to diazolidinyl urea (see above), is used as an antimicrobial agent very active against Gram-positive and Gram-negative bacteria, used as a synergist in combination with para- bens. It is used as a preservative in aqueous products, mainly in cosmetics, toiletries, and liquid soaps.

Safety

Imidurea is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. However, there have been some reports of contact dermatitis associated with imidurea, although these are relatively few considering its widespread use in cosmetics. Although imidurea releases formaldehyde, it does not appear to be associated with cross-sensitization with formaldehyde or other formaldehyde-releasing compounds.
LD50 (mouse, oral): 7.2 g/kg
LD50 (rabbit, skin): > 8 g/kg
LD50 (rat, oral): 11.3 g/kg

storage

Imidurea is hygroscopic and should be stored in a well-closed container in a cool, dry place.

Incompatibilities

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea is incompatible with strong oxidants. It is compatible with other preservatives including sorbic acid and quaternary ammonium compounds. It is also compatible with other pharmaceutical and cosmetic excipients including proteins, nonionic surfactants, and lecithin.

Regulatory Status

Included in the FDA Inactive Ingredients Database (topical preparations). Accepted for use in cosmetics in Europe and the USA. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Imidazolidinyl urea Preparation Products And Raw materials

Raw materials

Preparation Products

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Imidazolidinyl urea Suppliers

Americas 1 Belgium 2 China 282 Europe 3 France 2 Germany 9 India 19 Italy 2 Japan 2 South Korea 1 Spain 1 Switzerland 2 Syria 1 United Kingdom 8 United States 37 Global 372

Pure Chemistry Scientific Inc.

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View Lastest Price from Imidazolidinyl urea manufacturers

Speranza Chemical Co., Ltd.

Product: Imidazolidinyl Urea 39236-46-9
Price: US $20.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 200tons/ year
Release date: 2020-03-11

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Imidazolidinyl Urea 39236-46-9
Price: US $99.00-35.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 ton
Release date: 2024-05-09

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: Imidazolidinyl 39236-46-9
Price: US $60.00/kg
Min. Order: 1kg
Purity: 99
Supply Ability: 5000
Release date: 2024-05-15

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IMIDAZOLIDINYL UREA

IMIDUREA

1,1-METHYLENEBIS[3-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]

N,N''-METHYLENEBIS[N'-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]

N,N''-METHYLENEBIS[N-[3-(HYDROXYMETHYL)-2,5-DIOXO-4-IMIDAZOLIDINYL]UREA]

germall115

Imidurea (200 mg)

IMidazilydinyl urea (IMU)

N,N'-Methylenebis[N'-(3-hydroxymethyl-2,5-dioxo-4-imidazolidinyl)urea] Imidurea

1,1'-Methylenebis(3-(3-(hydroxyMethyl)-2,5-dioxoiMidazolidin-4-yl)urea)

Imidazolidnyl UREA

n,n-methylenebis n'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea

methanebis(n,n’-(5-ureido-2,4-diketotetrahydroimidazole)-n,n-dimethylol)

n,n’’-methylenebis(n’-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)-ure

n,n’’-methylenebis[n’-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-ure

Sept 115

Tristat 1U

Unicide U-13

N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea]

N.N''-Methylenebis-{N'-(3-hydroxymethyl)-2,5-dioxo-4-imidazolenyl-urea}

Euxyl K 200

Urea, N,N''-methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)

Imidazolidiny Urea

Biopure 100

Imidurea NF

Imidurea, 26-28% nitrogen

Urea, N,N-methylenebisN-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl-

,N'-Methylenebis[N'-(3-Hydroxymethyl-2,5-Dioxo-4-Imidazolidinyl)] Urea

1-imidazolidinylurea

Imidazolidinyl urea@100 μg/mL in MeOH

N,N'-Methylenebis[N'-3-(hydroxymethyl)-2,5-dioxo-4-imidazoli...

1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea

IMIDAZOLIDINYL UREA(JM 115)

Abiraterone acetate 154229-18-2

N,N'-Methylenebis[N'-3-(hydroxymethyl)-2,5-dioxo-4-

1,1'-Methylenebis(3-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea)

N,N-methylenebis N'-1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl urea

Imidazolidinyl

N,N'-Methylenebis[N'-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea

39236-46-9

39326-46-9

478491-02-8

C11H16N8H2O

C11H16N8O8

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