Poly(hexamethylenebiguanide)hydrochloride
Description Application Safety- Product Name
- Poly(hexamethylenebiguanide)hydrochloride
- CAS No.
- 32289-58-0
- Chemical Name
- Poly(hexamethylenebiguanide)hydrochloride
- Synonyms
- PHMB;Polihexanide;PHMB(20%);Polihexanide HCl;Polyhexamethylene Biguanidine HCl;BG 1;BG-IR;99%PHMB;PHMB 98;PHMB HCl
- CBNumber
- CB3511879
- Molecular Formula
- C10H23N5
- Formula Weight
- 213.32312
- MOL File
- 32289-58-0.mol
Poly(hexamethylenebiguanide)hydrochloride Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Water
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1S/C10H23N5/c1-9(11)14-7-5-3-4-6-8-15-10(12)13-2/h3-8H2,1-2H3,(H2,11,14)(H3,12,13,15)
- InChIKey
- SAGIGHPRUJPLKX-UHFFFAOYSA-N
- SMILES
- C(=N)(C)NCCCCCCNC(=N)NC
- CAS DataBase Reference
- 32289-58-0(CAS DataBase Reference)
- EPA Substance Registry System
- Poly(iminoimidocarbonyliminoimidocarbonyliminohexamethylene) hydrochloride (32289-58-0)
Safety
- Hazardous Substances Data
- 32289-58-0(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H318Causes serious eye damage
H330Fatal if inhaled
H351Suspected of causing cancer
H372Causes damage to organs through prolonged or repeated exposure
H410Very toxic to aquatic life with long lasting effects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P272Contaminated work clothing should not be allowed out of the workplace.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P281Use personal protective equipment as required.
P284Wear respiratory protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P314Get medical advice/attention if you feel unwell.
P320Specific treatment is urgent (see … on this label).
P321Specific treatment (see … on this label).
P330Rinse mouth.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P363Wash contaminated clothing before reuse.
P391Collect spillage. Hazardous to the aquatic environment
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 089694
- Product name
- Poly (hexamethylene biguanide) hydrochloride
- Purity
- 95+%
- Packaging
- 25g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 089694
- Product name
- Poly (hexamethylene biguanide) hydrochloride
- Purity
- 95+%
- Packaging
- 100g
- Price
- $348
- Updated
- 2021/12/16
- Product number
- A411573
- Product name
- Poly(hexamethylenebiguanide)hydrochloride
- Purity
- 20%inwater
- Packaging
- 1kg
- Price
- $121
- Updated
- 2021/12/16
- Product number
- A411573
- Product name
- Poly(hexamethylenebiguanide)hydrochloride
- Purity
- 20%inwater
- Packaging
- 1g
- Price
- $5
- Updated
- 2021/12/16
- Product number
- A411573
- Product name
- Poly(hexamethylenebiguanide)hydrochloride
- Purity
- 20%inwater
- Packaging
- 5g
- Price
- $6
- Updated
- 2021/12/16
Poly(hexamethylenebiguanide)hydrochloride Chemical Properties,Usage,Production
Description
PHMB is best known for its broad-spectrum antimicrobial and antifungal activity. It is the standard of care for treatment of Acanthamoeba keratitis and an ingredient in multipurpose contact lens solutions, such as Renu (Bauch & Lomb, Rochester, NY). PHMB is a cationic disinfectant that is effective against Gram-negative and Gram-positive bacteria through its electrostatic interaction with negative sites on the lipopolysaccharide component of bacterial cell membranes.
Application
Polyhexanide (polyhexamethylene biguanide, PHMB) is a polymer used as a disinfectant and antiseptic. In dermatological use, it is spelled polihexanide (INN) and sold under names such as Lavasept, Serasept, Prontosan and Omnicide. PHMB has been shown to be effective against Pseudomonas aeruginosa, Staphylococcus aureus (also the methicillin-resistant type, MRSA), Escherichia coli, Candida albicans (yeast), Aspergillus brasiliensis (mold), vancomycin-resistant enterococci, and Klebsiella pneumoniae (carbapenem-resistant enterobacteriaceae).
Safety
On the 20th of April 2018, the european commission decided to ban preservative uses of PHMB PT9 (Fibre, leather, rubber and polymerised materials preservatives). It’s still allowed for uses as disinfectants PT2 (Disinfectants and algaecides not intended for direct application to humans or animals). Furthermore, PHMB has been declared as a candidate for substitution by the ECHA.
Chemical Properties
Colorless to pale yellow solution
Chemical Properties
Poly(hexamethylenebiguanide) hydrochloride is also used as a surface disinfectant and is alleged to be suitable for skin disinfection. This compound has a slow effectand does not meet the practical requirementsfor prophylactic antiseptics in this respect. Although it is somewhat less effective than benzalkonium chloride, it is sometimes used instead of benzalkonium because it is less foamproducing under use conditions.
Uses
Broad spectrum antimicrobial polymer; binds and disrupts cytoplasmic membranes
Preparation
The preparation method of Poly(hexamethylenebiguanide)hydrochloride:By a certain proportion of 1; the own bisguanides of 6-and catalyst join in reaction vessel; under nitrogen protection, said mixture is heated to 80-200 DEGC and reacts, react 2-24 hour; reaction terminates; cooling blowing, obtains poly hexamethylene biguanide, poly hexamethylene biguanide aqueous acid is neutralized to pH value 5-9; and performing filtering so as to obtain a polyhexamethylene biguanidine salt.
Biological Activity
Polyhexamethylene biguanide (PHMB) is a cationic polymer with antimicrobial and antiviral properties. It has been commonly accepted that the antimicrobial activity is due to the ability of PHMB to perforate the bacterial phospholipid membrane leading ultimately to its death.
Properties and Applications
Polyhexamethylene biguanide hydrochloride (PHMB) is a new environment-friendly cationic water-soluble polymer. It is a water solution that can be used as a broad spectrum and high efficient disinfectant. It is low toxic, steady, non-flammable, non-explosive, and basically non-corrosive to stainless steel, copper, carbon steel, wood, and plastic. Because of its special bactericidal mechanisms, almost all kinds of bacteria shall be killed efficiently and will not develop resistance action.
Poly(hexamethylenebiguanide)hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Poly(hexamethylenebiguanide)hydrochloride manufacturers
- Product
- Phlyhexamethylene biguanidine 32289-58-0
- Price
- US $45.00/kg
- Min. Order
- 1kg
- Purity
- 95%
- Supply Ability
- 20ton
- Release date
- 2024-04-29
- Product
- Poly(iminocarbonimidoyliminocarbonimidoylimino-1,6-hexanediyl) hydrochloride 32289-58-0
- Price
- US $6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 2000KG/Month
- Release date
- 2024-08-07
- Product
- Polyhexamethylene biguanidine hydrochloride solution (PHMB) 32289-58-0
- Price
- US $6.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 95%
- Supply Ability
- 1000kg
- Release date
- 2024-03-20