4-IODO-2-METHYLPHENOL
- Product Name
- 4-IODO-2-METHYLPHENOL
- CAS No.
- 60577-30-2
- Chemical Name
- 4-IODO-2-METHYLPHENOL
- Synonyms
- NISTC60577302;4-IODO-O-CRESOL;4-iodine-2-cresol;4-IODO-2-METHYLPHENOL;Phenol, 4-iodo-2-Methyl-;4-Iodo-2-Methylphenol 97%
- CBNumber
- CB3428160
- Molecular Formula
- C7H7IO
- Formula Weight
- 234.03
- MOL File
- 60577-30-2.mol
4-IODO-2-METHYLPHENOL Property
- Melting point:
- 67-68 °C(lit.)
- Boiling point:
- 105-110 °C2 mm Hg(lit.)
- Density
- 1.7904 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 9.70±0.18(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 337358
- Product name
- 4-Iodo-2-methylphenol
- Purity
- 97%
- Packaging
- 10g
- Price
- $102.5
- Updated
- 2025/07/31
- Product number
- I737138
- Product name
- 4-Iodo-2-methylphenol
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- HCH0066676
- Product name
- 4-IODO-2-METHYLPHENOL
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $868.1
- Updated
- 2021/12/16
- Product number
- HCH0066676
- Product name
- 4-IODO-2-METHYLPHENOL
- Purity
- 95.00%
- Packaging
- 10G
- Price
- $1232.93
- Updated
- 2021/12/16
- Product number
- 9048AB
- Product name
- 4-Iodo-2-methylphenol
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
4-IODO-2-METHYLPHENOL Chemical Properties,Usage,Production
Uses
4-Iodo-2-methylphenol was used as starting reagent in the synthesis of an agonist for the peroxisome proliferator-activated receptor δ (PPARδ) GW501516, a potential antiobesity drug.
General Description
4-Iodo-2-methylphenol was prepared by direct iodination of 2-methylphenol in aqueous alcohol solvents by the action of a reagent prepared in situ from sodium hypochlorite and sodium iodide.
Synthesis
95-48-7
60577-30-2
General procedure for the synthesis of 4-iodo-2-cresol from o-cresol: to a stirred solution of o-cresol (1 mmol) in dichloromethane (CH2Cl2) or 1,2-dichloroethane ((CH2Cl)2) (0.1 M) was sequentially added Ph3PAuNTf2 (0.025 mmol, 19 mg; if using a 2:1 Ph3PAuNTf2 with toluene complex with toluene) and N-iodosuccinimide (NIS, 1.1 mmol, 248 mg). The reaction mixture was stirred at room temperature or reacted under reflux conditions until complete conversion of o-cresol was confirmed by thin layer chromatography (TLC) monitoring. Upon completion of the reaction, the solvent was evaporated under reduced pressure and the resulting crude product was purified by fast column chromatography using different ratios of hexane and ethyl acetate (EtOAc) as eluents, resulting in pure 4-iodo-2-cresol.
References
[1] Synlett, 2014, vol. 25, # 3, p. 399 - 402
[2] Chemistry - A European Journal, 2013, vol. 19, # 7, p. 2442 - 2449
[3] Asian Journal of Chemistry, 2018, vol. 30, # 7, p. 1659 - 1663
[4] Journal of Chemical Research, 2004, # 4, p. 294 - 295
[5] Chinese Chemical Letters, 2012, vol. 23, # 3, p. 261 - 264
4-IODO-2-METHYLPHENOL Preparation Products And Raw materials
Raw materials
Preparation Products
4-IODO-2-METHYLPHENOL Suppliers
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 400-6009262 16621234537
- Fax
- 021-64823266
- chenyj@titansci.com
- Country
- China
- ProdList
- 14101
- Advantage
- 59
- Tel
- 025-83697070
- Fax
- +86-25-83453306
- info@chemlin.com.cn
- Country
- China
- ProdList
- 16075
- Advantage
- 64
- Tel
- 18986259541
- Fax
- 027-87840182
- sales@3stc.com
- Country
- China
- ProdList
- 3764
- Advantage
- 58
- Tel
- +86057186818502 13588463833
- Fax
- Pls mail us for more information!
- info@sagechem.com
- Country
- China
- ProdList
- 10266
- Advantage
- 58
- Tel
- 86(512)5235 8471 17715136450
- Fax
- 86(512)5235 6881
- sales@shiyabiopharm.com
- Country
- China
- ProdList
- 4169
- Advantage
- 58
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
- Fax
- 0371-86159066
- Country
- China
- ProdList
- 2015
- Advantage
- 60
- Tel
- 0510-0510-86396359 13382276200
- sales@jalor-chem.com
- Country
- China
- ProdList
- 997
- Advantage
- 56
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 15385513552
- 2904539281@qq.com
- Country
- China
- ProdList
- 277
- Advantage
- 60
View Lastest Price from 4-IODO-2-METHYLPHENOL manufacturers
- Product
- 4-Iodo-2-methylphenol 60577-30-2
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2020-01-09