OXYTHIAMINE HYDROCHLORIDE

Product Name: OXYTHIAMINE HYDROCHLORIDE
CAS No.: 614-05-1
Chemical Name: OXYTHIAMINE HYDROCHLORIDE
Synonyms: OXYTHIAMINE HCL;Oxythiamine Chloride HCl;OXYTHIAMINE HYDROCHLORIDE;Oxametholone Hydrochloride;OXYTHIAMINE CHLORIDE HYDROCHLORIDE;hydroxythiaminechloridehydrochloride;OXYTHIAMINE CHLORIDE HCL CRYSTALLINE;hyl)-4-methyl-,chloride,monohydrochloride;Thiamine Impurity 19（Oxythiamine Chloride HCl）;Oxythiamine chloride hydrochloride, ≥95% (HPLC)
CBNumber: CB3428625
Molecular Formula: C12H17Cl2N3O2S
Formula Weight: 338.25
MOL File: 614-05-1.mol

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OXYTHIAMINE HYDROCHLORIDE Property

Melting point:: >190°C (subl.)
storage temp.: -20°C
solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form: Solid
color: White to Off-White
Stability:: Hygroscopic

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Safety

WGK Germany: 3
RTECS: XJ7034100

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: O4000
Product name: Oxythiamine chloride hydrochloride
Purity: ≥95% (HPLC)
Packaging: 1g
Price: $53.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: O4000
Product name: Oxythiamine chloride hydrochloride
Purity: ≥95% (HPLC)
Packaging: 5g
Price: $166
Updated: 2025/07/31

Cayman Chemical

Product number: 29953
Product name: Oxythiamine (chloride hydrochloride)
Packaging: 1g
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 29953
Product name: Oxythiamine (chloride hydrochloride)
Packaging: 25g
Price: $479
Updated: 2024/03/01

Cayman Chemical

Product number: 29953
Product name: Oxythiamine (chloride hydrochloride)
Packaging: 5g
Price: $140
Updated: 2024/03/01

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OXYTHIAMINE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

thiamine antagonist

Uses

Oxythiamine chloride hydrochloride is suitable for use:

as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells
as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines
in the synthesis of oxythiamineH picrolonate salt

Definition

ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid.

General Description

Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.

Biochem/physiol Actions

Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.

in vivo

Oxythiamine chloride hydrochloride (100-500 mg/kg, i.p. 4 days) inhibits tumor growth in Ehrlich's ascites tumor hosting mice^[2].
Oxythiamine chloride hydrochloride (250 or 500 mg/kg, daily for 5 week) inhibits tumor cell metastasis via inhibition of MMPs in mice implanted (s.c.) with LLC cells^[4].

Animal Model:	Ehrlich's ascites tumor hosting mice^[2]
Dosage:	100-500 mg/kg
Administration:	i.p., 4 days
Result:	Inhibited tumor growth by 43% at 300 mg/kg and 84% at 500 mg/kg.

OXYTHIAMINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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OXYTHIAMINE HYDROCHLORIDE Suppliers

China 35 Germany 2 India 2 Switzerland 1 United States 7 Global 47

J & K SCIENTIFIC LTD.

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Sigma-Aldrich

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614-05-1, OXYTHIAMINE HYDROCHLORIDERelated Search:

OXYTHIAMINE HYDROCHLORIDE

5-(2-HYDROXYETHYL)-3-(4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL)-4-METHYLTHIAZOLIUM CHLORIDE

5-[2-HYDROXYETHYL]-3-[4-HYDROXY-2-METHYL-5-PYRIMIDINYLMETHYL]-4-METHYLTHIAZOLIUM CHLORIDE HYDROCHLORIDE

Oxametholone Hydrochloride

hydroxythiaminechloridehydrochloride

hyl)-4-methyl-,chloride,monohydrochloride

OXYTHIAMINE CHLORIDE HYDROCHLORIDE

OXYTHIAMINE HCL

OXYTHIAMINE HYDROCHLORIDE

OXYTHIAMINE CHLORIDE HCL CRYSTALLINE

5-[[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one chloride hydrochloride

5-[[5-(2-hydroxyethyl)-4-methyl-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one chloride hydrochloride

5-(2-Hydroxyethyl)-4-methyl-3-[(2-methyl-6-oxo-1,6-dihydro-5-pyrimidinyl)methyl]-1,3-thiazol-3-ium chloride hydrochloride (1:1:1)

5-(2-Hydroxyethyl)-4-methyl-3-((2-methyl-6-oxo-1,6-dihydropyrimidin-5-yl)methyl)thiazol-3-ium chloride hydrochloride

Thiamine Impurity 19（Oxythiamine Chloride HCl）

Oxythiamine Chloride HCl

Oxythiamine chloride hydrochloride, ≥95% (HPLC)

Thiamine Impurity 19 (Oxythiamine Chloride Hydrochloride)

614-05-1

C12H17Cl2N3O2S

C12H16ClN3O2SHCl

C12H16N3O2SClHCl

C12H16N3O2SClClH

Biochemistry

Vitamin Derivatives

Vitamins