4-IODO-3-NITROPHENOL

Product Name: 4-IODO-3-NITROPHENOL
CAS No.: 50590-07-3
Chemical Name: 4-IODO-3-NITROPHENOL
Synonyms: 3-Iodo-4-nitrophenol.;Phenol, 3-iodo-4-nitro-;4-IODO-3-NITROPHENOL 97%
CBNumber: CB3434549
Molecular Formula: C6H4INO3
Formula Weight: 265.01
MOL File: 50590-07-3.mol

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4-IODO-3-NITROPHENOL Property

Melting point:: 153-159 °C
Boiling point:: 382.5±37.0 °C(Predicted)
Density: 2.176
storage temp.: 2-8°C(protect from light)
pka: 6.39±0.10(Predicted)
Appearance: Light yellow to yellow Solid

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Safety

Hazard Codes: Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 36/37/39-26
HS Code: 2908990000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: I715733
Product name: 3-Iodo-4-nitrophenol
Packaging: 500mg
Price: $175
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-H-17
Product name: 3-Iodo-4-nitrophenol
Packaging: 1g
Price: $240
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4654-H-17
Product name: 3-Iodo-4-nitrophenol
Packaging: 5G
Price: $768
Updated: 2021/12/16

AK Scientific

Product number: J55270
Product name: 3-Iodo-4-nitrophenol
Packaging: 1g
Price: $49
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0036018
Product name: 3-IODO-4-NITROPHENOL
Purity: 95.00%
Packaging: 10G
Price: $1963.5
Updated: 2021/12/16

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4-IODO-3-NITROPHENOL Chemical Properties,Usage,Production

Synthesis

626-02-8

27783-55-7

50590-07-3

General procedure for the synthesis of 5-iodo-2-nitrophenol and 3-iodo-4-nitrophenol from 3-iodophenol: 3.0 mL of fuming nitric acid (75 mmol) in 12 mL of glacial acetic acid was slowly added dropwise to 15.03 g (68.3 mmol) of 3-iodophenol dissolved in 60 mL of glacial acetic acid over a 25-minute period and the reaction flask was placed in an ice bath to cool. After the dropwise addition was completed, the reaction mixture was continued to be stirred at room temperature for 30 min. Subsequently, the reaction solution was poured into ice water and concentrated under vacuum to remove most of the solvent. The residue was dissolved in 150 mL of water and then extracted with dichloromethane (2 x 300 mL). The organic phases were combined, dried with anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure to give 17 g of crude product. Separation by silica gel medium-pressure chromatography (eluent ratio 1:2 ethyl acetate:hexane) afforded 3-iodo-4-nitrophenol (6.93 g, 26.1 mmol, 38% yield), melting point 121-123 °C; 1H NMR (CDCl3, 300 MHz) δ 7.98 (d, 1H, J = 9 Hz), 7.54 (d, 1H, J = 3 Hz) 6.92 (dd, 1H, J = 9, 3 Hz), 5.54 (bs, 1H); IR (KBr) 3150 (wide), 1600, 1580, 1512, 1404, 1336, 1298, 1212, 1121, 1023, 870 cm?1; and 3-iodo-6-nitrophenol (3.07 g, 11.6 mmol, yield 17%), melting point 92-94 °C after recrystallization from dichloromethane/hexane (literature value 96 °C; Hodgson, H.H. et al., 1927); 1H NMR (CDCl3, 300 MHz) δ 10.53 (s, 1H), 7.76 (d, 1H, J = 9.0 Hz), 7.59 (d, 1H, J = 2.0 Hz), 7.33 ( dd, 1H, J = 9.0, 2.0 Hz); 13C NMR (CDCl3; assisted attribution by HMQC) δ 105.2 (C-3), 125.6 (C-5), 129.2 (C-2), 129.7 (C-4), 133.4 (C-6), 154.6 (C-1); IR (KBr) 3430 (broad), 1604, 1671, 1518, 1463 1571, 1518, 1463, 1317, 1225, 1172, 1055, 888 cm?1; Calculated elemental analysis (C6H4INO3): C, 27.19; H, 1.52; N, 5.29. Measured values: C, 27.36; H, 1.57; N, 5.15.

References

[1] Tetrahedron, 2010, vol. 66, # 47, p. 9252 - 9262
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 16, p. 4960 - 4971
[3] Patent: WO2005/95347, 2005, A1. Location in patent: Page/Page column 41
[4] Journal of the Chemical Society, 1927, p. 634
[5] Journal of the Chemical Society, 1925, vol. 127, p. 1602

4-IODO-3-NITROPHENOL Preparation Products And Raw materials

Raw materials

Preparation Products

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4-IODO-3-NITROPHENOL Suppliers

China 50 Germany 1 India 2 Japan 1 Switzerland 1 United Kingdom 8 United States 9 Global 72

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View Lastest Price from 4-IODO-3-NITROPHENOL manufacturers

Career Henan Chemical Co

Product: 4-IODO-3-NITROPHENOL 50590-07-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2020-01-11

50590-07-3, 4-IODO-3-NITROPHENOLRelated Search:

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50590-07-3

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