ChemicalBook > CAS DataBase List > 3-BROMO-5-CHLOROTOLUENE

3-BROMO-5-CHLOROTOLUENE

Product Name: 3-BROMO-5-CHLOROTOLUENE
CAS No.: 329944-72-1
Chemical Name: 3-BROMO-5-CHLOROTOLUENE
Synonyms: 3-bromo-5-chlorotlouene;3-BROMO-5-CHLOROTOLUENE;3-Bromo-5-chlorotoluene 98%;3-Chloro-5-methyl-bromobenzene;1-BROMO-3-CHLORO-5-METHYLBENZENE;Benzene,1-bromo-3-chloro-5-methyl-
CBNumber: CB3442861
Molecular Formula: C7H6BrCl
Formula Weight: 205.48
MOL File: 329944-72-1.mol

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3-BROMO-5-CHLOROTOLUENE Property

Melting point:: 25℃
Boiling point:: 222.3±20.0℃ (760 Torr)
Density: 1.535±0.06 g/cm3 (20 ºC 760 Torr)
Flash point:: 101.5±11.9℃
storage temp.: Sealed in dry,Room Temperature
solubility: Chloroform, Ethyl Acetate
form: Solid
color: Pale Yellow
InChI: InChI=1S/C7H6BrCl/c1-5-2-6(8)4-7(9)3-5/h2-4H,1H3
InChIKey: YRIKDGJWRMHTJP-UHFFFAOYSA-N
SMILES: C1(Br)=CC(C)=CC(Cl)=C1

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 22
Hazard Note: Irritant
HS Code: 2903998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: B682490
Product name: 3-Bromo-5-chlorotoluene
Packaging: 10g
Price: $130
Updated: 2021/12/16

TRC

Product number: B682490
Product name: 3-Bromo-5-chlorotoluene
Packaging: 100g
Price: $375
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB140165
Product name: 1-Bromo-3-chloro-5-methylbenzene
Packaging: 100g
Price: $462
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0021313
Product name: 3-BROMO-5-CHLORO TOLUENE
Purity: 95.00%
Packaging: 5G
Price: $864.27
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 68224
Product name: 3-Bromo-5-chlorotoluene
Packaging: 100g
Price: $875
Updated: 2021/12/16

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3-BROMO-5-CHLOROTOLUENE Chemical Properties,Usage,Production

Uses

3-Bromo-5-chlorotoluene is a reagent used in the synthesis of novel benzophenones towards the discovery of potent, next generation HIV nonnucleoside reverse transcriptase inhibitors.

Synthesis

135340-78-2

329944-72-1

2-Bromo-6-chloro-4-methylaniline (30 mmol) was used as a starting material, which was dissolved in a mixed solution of acetic acid (60 mL), water (25 mL), and concentrated hydrochloric acid (7 mL), and the reaction system was subsequently cooled to 5 °C. A solution of sodium nitrite (48 mmol, 3.31 g) in water (12 mL) was added slowly and dropwise while keeping the temperature below 5 °C. After the dropwise addition, the reaction mixture was continued to be stirred at 5-10 °C for 2 hours. Subsequently, the reaction solution was poured into a 50% hypophosphite solution pre-cooled to 0 °C and stirred for 48 h at room temperature. Upon completion of the reaction, extraction was carried out with dichloromethane (3 x 120 mL). The organic phases were combined, washed with saturated saline (100 mL), dried over anhydrous sodium sulfate, and concentrated under reduced pressure to remove the solvent. Finally, the residue was purified by fast column chromatography to obtain the target product 3-bromo-5-chlorotoluene.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2016, vol. 26, # 22, p. 5568 - 5572
[2] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882
[3] Journal of Medicinal Chemistry, 2001, vol. 44, # 12, p. 1866 - 1882

3-BROMO-5-CHLOROTOLUENE Preparation Products And Raw materials

Raw materials

Preparation Products

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329944-72-1, 3-BROMO-5-CHLOROTOLUENERelated Search:

3-BROMO-5-CHLORO-4-IODOBENZOTRIFLUORIDE brotianide 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZOIC ACID Bromochlorophenol Blue sodium salt 2-BROMO-6-CHLORO-4-(TRIFLUOROMETHYL)ANILINE 4-BROMO-2-CHLORO-6-METHYLPHENOL 3-Bromo-5-chlorosalicylaldehyde 3-BROMO-5-CHLORO-2,6-DIMETHOXYBENZAMIDE 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE Pigment Green 36 BROMOCHLOROPHEN 4-Bromo-2-chloro-6-methylaniline 2-BROMO-5-CHLOROTOLUENE 99%,6-BROMO-3-CHLOROTOLUENE,2-BROMO-5-CHLOROTOLUENE 2-BROMO-3-CHLOROTOLUENE 2-BROMO-4-CHLOROTOLUENE 5-BROMO-2-CHLOROTOLUENE,5-BROMO-3-CHLOROTOLUENE,5-Bromo-2-chlorotoluene, 97+%,5-Bromo-2-chlorotoluene,98% 3-Chlorobenzyl bromide alpha-bromo-o-chlorotoluen

3-Bromo-5-chlorotoluene 98%

3-BROMO-5-CHLOROTOLUENE

1-BROMO-3-CHLORO-5-METHYLBENZENE

3-bromo-5-chlorotlouene

3-Chloro-5-methyl-bromobenzene

Benzene,1-bromo-3-chloro-5-methyl-

329944-72-1

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Bromides