3-Chlorobenzyl bromide
- Product Name
- 3-Chlorobenzyl bromide
- CAS No.
- 766-80-3
- Chemical Name
- 3-Chlorobenzyl bromide
- Synonyms
- orobenzyL;ChlorobenzylbroMide;3-Chlorobenzyl bromi;M-CHLOROBENZYL BROMIDE;3-CHLOROBENZYL BROMIDE;α-Bromo-m-chlorotoluene;m-Chloro-α-bromotoluene;à-bromo-3-chlorotoluene;A-BROMO-3-CHLOROTOLUENE;A-BROMO-M-CHLOROTOLUENE
- CBNumber
- CB8390505
- Molecular Formula
- C7H6BrCl
- Formula Weight
- 205.48
- MOL File
- 766-80-3.mol
3-Chlorobenzyl bromide Property
- Melting point:
- 15 °C
- Boiling point:
- 109-110 °C/12 mmHg (lit.)
- Density
- 1.565 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.588(lit.)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,2-8°C
- form
- powder to lump to clear liquid
- color
- White or Colorless to Yellow
- Specific Gravity
- 1.565
- Water Solubility
- DECOMPOSES
- Sensitive
- Lachrymatory
- BRN
- 636504
- CAS DataBase Reference
- 766-80-3(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, 1-(bromomethyl)-3-chloro-(766-80-3)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- F
- 19
- Hazard Note
- Corrosive/Lachrymatory
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29039990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 136727
- Product name
- 3-Chlorobenzyl bromide
- Purity
- 97%
- Packaging
- 10g
- Price
- $42.9
- Updated
- 2025/07/31
- Product number
- 136727
- Product name
- 3-Chlorobenzyl bromide
- Purity
- 97%
- Packaging
- 50g
- Price
- $125
- Updated
- 2025/07/31
- Product number
- C1105
- Product name
- 3-Chlorobenzyl Bromide
- Packaging
- 5G
- Price
- $20
- Updated
- 2025/07/31
- Product number
- C1105
- Product name
- 3-Chlorobenzyl Bromide
- Packaging
- 25G
- Price
- $78
- Updated
- 2025/07/31
- Product number
- C427620
- Product name
- 3-Chlorobenzyl bromide
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
3-Chlorobenzyl bromide Chemical Properties,Usage,Production
Chemical Properties
Colorless liquid
Uses
3-Chlorobenzyl bromide was used in the synthesis of symmetrical and unsymmetrical benzyl thioethers. It was used as starting reagent during the synthesis of 1-(3-chlorobenzyl)-2-(pyrrolidin-1-ylmethyl)-1H-benzimidazole dihydrochloride.
General Description
3-Chlorobenzyl bromide reacts with aminoethanol and NaH to yield aminoethyl 3-chlorobenzyl ether.
Synthesis
108-41-8
766-80-3
General procedure for the synthesis of 3-chlorobenzyl bromide from 3-chlorotoluene: In a reaction flask fitted with a stirrer, reflux condenser, and thermometer, m-chlorotoluene (5.1 g, 40 mmol), sodium bromate (2.1 g, 14 mmol), sodium bromide (2.9 g, 28 mmol), and dichloromethane (25 mL) were added. A tail gas absorption device was installed and heated to reflux. AIBN (0.025 g) and BPO (0.025 g) were dissolved in 5 mL of dichloromethane and quickly added to the reaction flask. Subsequently, diluted concentrated sulfuric acid (2.1 g, 21 mmol, diluted with 2.5 mL of water) was added slowly and dropwise. Upon completion of the reaction, the progress of the reaction was monitored by gas chromatography. The mixture was cooled to room temperature, saturated sodium bisulfite solution (10 mL) was added and stirred until the solution faded from red to colorless. The aqueous phase was extracted twice with dichloromethane (10 mL x 2), the organic phases were combined, washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent was petroleum ether) to give 6.8 g of 3-chlorobenzyl bromide as a colorless liquid in 83% yield.
References
[1] Patent: CN107098791, 2017, A. Location in patent: Paragraph 0043-0045
[2] Synthetic Communications, 2010, vol. 40, # 7, p. 998 - 1003
[3] Synthesis (Germany), 2018, vol. 50, # 24, p. 4933 - 4939
[4] Chinese Chemical Letters, 2011, vol. 22, # 4, p. 382 - 384
[5] Journal of the Chemical Society, 1932, p. 55,66
3-Chlorobenzyl bromide Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chlorobenzyl bromide manufacturers
- Product
- 3-Chlorobenzyl bromide 766-80-3
- Price
- US $100.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2023-12-25
- Product
- 3-chlorobenzylbromide 766-80-3
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2019-07-10