1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
- Product Name
- 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
- CAS No.
- 146447-18-9
- Chemical Name
- 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
- Synonyms
- 2-Chloro-4-fluoro-5-bromoanisole;5-BROMO-2-CHLORO-4-FLUOROANISOLE;5-Bromo-2-chloro-4-fluoro-1-methoxybenzene;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE;Benzene,1-bromo-4-chloro-2-fluoro-5-methoxy-;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE ISO 9001：2015 REACH
- CBNumber
- CB3443626
- Molecular Formula
- C7H5BrClFO
- Formula Weight
- 239.47
- MOL File
- 146447-18-9.mol
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Property
- Melting point:
- 72.0 to 76.0 °C
- Boiling point:
- 237.7±35.0 °C(Predicted)
- Density
- 1.642±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- color
- White to Light yellow
Safety
- Hazard Codes
- Xn
- HS Code
- 2909309090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
N-Bromosuccinimide Price
- Product number
- B5354
- Product name
- 5-Bromo-2-chloro-4-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 200mg
- Price
- $68
- Updated
- 2025/07/31
- Product number
- B5354
- Product name
- 5-Bromo-2-chloro-4-fluoroanisole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $203
- Updated
- 2025/07/31
- Product number
- B874608
- Product name
- 5-Bromo-2-chloro-4-fluoroanisole
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0061950
- Product name
- 1-Bromo-4-chloro-2-fluoro-5-methoxybenzene
- Purity
- 99.25%
- Packaging
- 1g
- Price
- $69
- Updated
- 2021/12/16
- Product number
- CS-0061950
- Product name
- 1-Bromo-4-chloro-2-fluoro-5-methoxybenzene
- Purity
- 99.25%
- Packaging
- 250mg
- Price
- $26
- Updated
- 2021/12/16
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Chemical Properties,Usage,Production
Synthesis
148254-32-4
74-88-4
146447-18-9
1. 5-bromo-2-chloro-4-fluorophenol (1.0 g, 4.4 mmol) was dissolved in N,N-dimethylformamide (DMF, 5 mL) in a dry reaction flask. 2. iodomethane (0.55 mL, 8.8 mmol) and potassium carbonate (1.2 g, 8.9 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature for 20 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). 4. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture. 5. The reaction mixture was extracted with ether (20 mL x 3) and the organic phases were combined. 6. The organic phase was washed with saturated saline (20 mL) and dried over anhydrous magnesium sulfate. 7. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the crude product. 8. The crude product was further purified (if required) to give 5-bromo-2-chloro-4-fluoroanisole (0.951 g, 90% yield) as a white solid. 9. 9. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ3.88 (s, 3H), 7.07 (d, J=5.8 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H) and 19F-NMR (376 MHz, CDCl3): δ-116.1 (s, 1F).
References
[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0577; 0585
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0163
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0242; 0244
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE manufacturers
- Product
- 1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene 146447-18-9
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-17
- Product
- 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE 146447-18-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12