ChemicalBook > CAS DataBase List > 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE

1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE

Product Name
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
CAS No.
146447-18-9
Chemical Name
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
Synonyms
2-Chloro-4-fluoro-5-bromoanisole;5-BROMO-2-CHLORO-4-FLUOROANISOLE;5-Bromo-2-chloro-4-fluoro-1-methoxybenzene;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE;Benzene,1-bromo-4-chloro-2-fluoro-5-methoxy-;1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE ISO 9001：2015 REACH
CBNumber
CB3443626
Molecular Formula
C7H5BrClFO
Formula Weight
239.47
MOL File
146447-18-9.mol
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1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Property

Melting point:
72.0 to 76.0 °C
Boiling point:
237.7±35.0 °C(Predicted)
Density 
1.642±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
powder to crystal
color 
White to Light yellow
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Safety

Hazard Codes 
Xn
HS Code 
2909309090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

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N-Bromosuccinimide Price

TCI Chemical
Product number
B5354
Product name
5-Bromo-2-chloro-4-fluoroanisole
Purity
>98.0%(GC)
Packaging
200mg
Price
$68
Updated
2025/07/31
TCI Chemical
Product number
B5354
Product name
5-Bromo-2-chloro-4-fluoroanisole
Purity
>98.0%(GC)
Packaging
1g
Price
$203
Updated
2025/07/31
TRC
Product number
B874608
Product name
5-Bromo-2-chloro-4-fluoroanisole
Packaging
100mg
Price
$65
Updated
2021/12/16
ChemScene
Product number
CS-0061950
Product name
1-Bromo-4-chloro-2-fluoro-5-methoxybenzene
Purity
99.25%
Packaging
1g
Price
$69
Updated
2021/12/16
ChemScene
Product number
CS-0061950
Product name
1-Bromo-4-chloro-2-fluoro-5-methoxybenzene
Purity
99.25%
Packaging
250mg
Price
$26
Updated
2021/12/16
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1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Chemical Properties,Usage,Production

Synthesis

148254-32-4

74-88-4

146447-18-9

1. 5-bromo-2-chloro-4-fluorophenol (1.0 g, 4.4 mmol) was dissolved in N,N-dimethylformamide (DMF, 5 mL) in a dry reaction flask. 2. iodomethane (0.55 mL, 8.8 mmol) and potassium carbonate (1.2 g, 8.9 mmol) were added sequentially. 3. The reaction mixture was stirred at room temperature for 20 hours and the progress of the reaction was monitored by thin layer chromatography (TLC). 4. Upon completion of the reaction, the reaction was quenched by adding water (20 mL) to the reaction mixture. 5. The reaction mixture was extracted with ether (20 mL x 3) and the organic phases were combined. 6. The organic phase was washed with saturated saline (20 mL) and dried over anhydrous magnesium sulfate. 7. The desiccant was removed by filtration, and the filtrate was concentrated under reduced pressure to obtain the crude product. 8. The crude product was further purified (if required) to give 5-bromo-2-chloro-4-fluoroanisole (0.951 g, 90% yield) as a white solid. 9. 9. The structure of the product was confirmed by 1H-NMR (400 MHz, CDCl3): δ3.88 (s, 3H), 7.07 (d, J=5.8 Hz, 1H), 7.19 (d, J=8.0 Hz, 1H) and 19F-NMR (376 MHz, CDCl3): δ-116.1 (s, 1F).

References

[1] Patent: US2016/24110, 2016, A1. Location in patent: Paragraph 0577; 0585
[2] Patent: JP2016/56157, 2016, A. Location in patent: Paragraph 0163
[3] Patent: JP2016/60742, 2016, A. Location in patent: Paragraph 0242; 0244

1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
1-Bromo-4-chloro-2-fluoro-5-methoxy-benzene 146447-18-9
Price
US $0.00-0.00/KG
Min. Order
10mg
Purity
99%HPLC
Supply Ability
2000tons
Release date
2020-01-17
Career Henan Chemical Co
Product
1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE 146447-18-9
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-12

146447-18-9, 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENERelated Search:

2-Chloro-4-fluoroanisole 1-Bromo-4-chloro-2-fluorobenzene 5-BROMO-2-CHLORO-4-FLUORO-PHENOL 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE 5-Bromo-2-chlorophenol 5-BROMO-2-CHLOROANISOLE 3-Bromo-4-fluorophenol

  • 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE
  • 5-BROMO-2-CHLORO-4-FLUOROANISOLE
  • 5-Bromo-2-chloro-4-fluoro-1-methoxybenzene
  • Benzene,1-bromo-4-chloro-2-fluoro-5-methoxy-
  • 1-BROMO-4-CHLORO-2-FLUORO-5-METHOXY-BENZENE ISO 9001：2015 REACH
  • 2-Chloro-4-fluoro-5-bromoanisole
  • 146447-18-9
  • C7H5OBrClF