10-Deacetylbaccatin III

Product Name: 10-Deacetylbaccatin III
CAS No.: 32981-86-5
Chemical Name: 10-Deacetylbaccatin III
Synonyms: 10-DAB;10-DEACETYLBACCATIN;10-DAB Ⅲ;10-Deacetyl Baccatin lll;ó;NH24841;10DBA III;10-DAB-III;10-Dab98.5%;10-Deacetyl
CBNumber: CB3447497
Molecular Formula: C29H36O10
Formula Weight: 544.59
MOL File: 32981-86-5.mol

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10-Deacetylbaccatin III Property

Melting point:: 231-236 °C
alpha: -44.5 º (c=1, methanol 25 ºC)
Boiling point:: 717℃
Density: 1.2007 (rough estimate)
refractive index: 1.5376 (estimate)
Flash point:: >110°(230°F)
storage temp.: Sealed in dry,Room Temperature
solubility: methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)
form: Powder
pka: 11.50±0.70(Predicted)
color: white
Water Solubility: INSOLUBLE
InChIKey: YWLXLRUDGLRYDR-IYNRKYTHSA-N
SMILES: O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@@]12[H]
LogP: 0.156 (est)
CAS DataBase Reference: 32981-86-5(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 23/24/25
Safety Statements: 45-38-36/37/39-28A-24/25
RIDADR: 1544
WGK Germany: 3
HazardClass: 6.1(b)
PackingGroup: III
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H340May cause genetic defects

H350May cause cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: D3676
Product name: 10-Deacetylbaccatin III from Taxus baccata
Purity: ≥95% (HPLC)
Packaging: 5mg
Price: $371
Updated: 2024/03/01

Sigma-Aldrich

Product number: D3676
Product name: 10-Deacetylbaccatin III from Taxus baccata
Purity: ≥95% (HPLC)
Packaging: 1mg
Price: $108
Updated: 2023/06/20

TCI Chemical

Product number: D4148
Product name: 10-Deacetylbaccatin III
Purity: >98.0%(HPLC)
Packaging: 100mg
Price: $111
Updated: 2024/03/01

TCI Chemical

Product number: D4148
Product name: 10-Deacetylbaccatin III
Purity: >98.0%(HPLC)
Packaging: 500mg
Price: $352
Updated: 2024/03/01

Alfa Aesar

Product number: J66228
Product name: 10-Deacetylbaccatin III, 95%
Packaging: 25mg
Price: $734
Updated: 2021/12/16

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10-Deacetylbaccatin III Chemical Properties,Usage,Production

Chemical Properties

10-Deacetylbaccatin III is White Solid

Uses

10-Deacetylbaccatin III is a intermediate in the synthesis of Taxol and derivatives

Uses

10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le

Uses

10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives.

Definition

ChEBI: 10-deacetylbaccatin III is a tetracyclic diterpenoid and a secondary alpha-hydroxy ketone. It is functionally related to a baccatin III.

General Description

10-Deacetylbaccatin III, also known as Paclitaxel Impurity 19, is an impurity of Paclitaxel. Paclitaxel is a chemotherapy drug. Chemotherapy is a treatment that destroys cancer cells using anti-cancer drugs. Paclitaxel is the non-branded name of the drug, but you may hear it called by one of its brand names such as Taxol. Some people are given a drug called nab-paclitaxel (Abraxane).

Biological Activity

10-dab (also known as 10-deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the pacific yew tree taxus brevifolia as well as other species of the genus taxus. due to the low availability of taxol from its natural sources, 10-dab is used as a raw material for the preparation of taxol and its derivatives. being easily extracted from the annual cute of the yew leaves, 10-dab has a very folded chemical structure with the α hydroxyl group hindered at c-13 easily to form a hydrogen bond with the 4α acetyl group.f. gueritte-voegelein, v. senilh, b. david, d. guenard and p. potier. chemical studies of 10-deacetyl baccatin iii hemisynthesis of taxol derivatives. tetrahedron 1986; 42(16): 4451-4460

10-Deacetylbaccatin III Preparation Products And Raw materials

Raw materials

Preparation Products

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10-Deacetylbaccatin III Suppliers

Americas 1 Belgium 2 Canada 4 China 456 China Hong Kong 1 Czech Republic 1 Europe 3 Germany 5 India 58 Italy 1 Japan 3 South Korea 1 Switzerland 5 Ukraine 1 United Kingdom 13 United States 62 Global 617

Zhuhai Anzhe Biotechnology Co,Ltd.

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ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
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Wuhu Nuowei Chemical Technology Co., Ltd

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Chengdu Gupte Biotechnology Co., Ltd.

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J & K SCIENTIFIC LTD.

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Country: China
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Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
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Country: China
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INTATRADE GmbH

Tel: +49 3493/605464
Fax: +49 3493/605470
Email: sales@intatrade.de
Country: Germany
ProdList: 3576
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View Lastest Price from 10-Deacetylbaccatin III manufacturers

Guangzhou Tosun Pharmaceutical Limited

Product: Paclitaxel Impurity 19 32981-86-5
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 99.46%
Supply Ability: 10g/month
Release date: 2023-05-10

Henan Fengda Chemical Co., Ltd

Product: 10-Deacetylbaccatin III 32981-86-5
Price: US $35.00-1.40/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-02

Wuhan Quanjinci New Material Co.,Ltd.

Product: 10-Deacetylbaccatin III 32981-86-5
Price: US $15.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 1000000tons
Release date: 2023-11-15

32981-86-5, 10-Deacetylbaccatin IIIRelated Search:

Acetylferrocene Acetylacetone N-ACETYL-L-TYROSINE ETHYL ESTER Baccatine III (2R,3S)-N-Benzoyl-3-phenyl Isoserine Docetaxel Metabolite M4 10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36 Docetaxel (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate HLCSYHHJEMPKSY-RRKHLBDSSA-N 4-Dichloroethoxy-carbonyl docetaxel 2-Azetidinone, 3-hydroxy-4-phenyl-1-[(1S)-1-phenylethyl]-, (3R,4S)- Docetaxel Impurity 15

10-Deacetyl Baccatin lll

Deacetylbaccatin III

10-deacetylbaccatin11

10-deacetylbaccatiniii(extaxusbaccata)

10-DAB

10-DEACETYLBACCATIN III FROMTAXUS BACCAT A

10-Dab98.5%

10-Deacetylbaccatine(III)

10-Deacetyl Baccatin &cent

10-Deacetylbaccatine

10-DAB III(10-DEACETYL BACCATIN III) 99%

DEACETYLBACCATIN-III, 10(P)

10-DAB(10-deacetylbaccatin)

10-Deacetyl

DESACETYLBACCATINE

BACCATIN III, 10-DEACETYL-

10-Deacetylbaccatin III

10-O-DEACETYLBACCATIN III

high quality 10-deacetylbacctin Ⅲ(10-DAB) CAS 32981-86-5 CAS NO.32981-86-5

2-bromo-4-chloropropiophenone CAS NO.877-37-2

10-Deacetylbaccatin III 32981-86-5

Paclitaxel Impurity 19

Docetaxel EP impurity E，10-desacetyl-baccatin III

10-Deacetylbacatin III

Docetaxel IMpurity E (10-Deacetyl Baccatin III)

ó

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-

Docetaxel impurity E

10-Deacetylbaccatin III, >=99%

10-deacetyl Chiba Cardin Ⅲ

12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3

(2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-

10-DEACETYLBACCATIN III (EX TAXUS BACCATA), CONTAINS CA 0.5 MOLE OF METHANOL 95%

10-DEACETYL BACCATIN (10-DAB )

10-Desacetylbaccatin III

7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-,[2aR-(2aα,4β,4aβ,6β,9α,11α,12α,12aα,12bα)]-

12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

10-DAB-III

10-DEACETYLBACCATIN

10-DEACETYLBACCATIN III, 95%, FROM TAXUS BACCATA

10-Deacetyl Baccatin ￠ó

12b-(Acetyloxy)-12-(Benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11-Tetrahydroxy-4a,8,13,13-Tetramethyl-7,11-Methano-5h-Cyclodeca[3,4]

10-Deacetylbaccatin III ,97%

10-DAB Ⅲ

10-Decaacetyl baccatin III

10DBA III

10-Deacetyl baccatine IIII

10-Deacetylbaccatin Ⅲ(10-DAB)

5β,20-Epoxy-4-(acetyloxy)-1,7β,10β,13α-tetrahydroxy-9-oxotax-11-en-2α-yl benzoate

(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one

Docetaxel EP Impurity E

Docetaxel Impurity 5(Docetaxel EP Impurity E)

NH24841

10-DAB：10-Deacetylbaccatin III

Docetaxel EP Impurity E (10-Deacetyl Baccatin III)

10-DeacetylbaccatinIII&gt

Docetaxel impurity E CRS

3-(5-chloro-2-fluorobenzyl)isonicotinic acid