10-Deacetylbaccatin III
- Product Name
- 10-Deacetylbaccatin III
- CAS No.
- 32981-86-5
- Chemical Name
- 10-Deacetylbaccatin III
- Synonyms
- 10-DAB;10-DEACETYLBACCATIN;10-DAB Ⅲ;10-Deacetyl Baccatin lll;ó;NH24841;10DBA III;10-DAB-III;10-Dab98.5%;10-Deacetyl
- CBNumber
- CB3447497
- Molecular Formula
- C29H36O10
- Formula Weight
- 544.59
- MOL File
- 32981-86-5.mol
10-Deacetylbaccatin III Property
- Melting point:
- 231-236 °C
- alpha
- -44.5 º (c=1, methanol 25 ºC)
- Boiling point:
- 717℃
- Density
- 1.2007 (rough estimate)
- refractive index
- 1.5376 (estimate)
- Flash point:
- >110°(230°F)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)
- form
- Powder
- pka
- 11.50±0.70(Predicted)
- color
- white
- Water Solubility
- INSOLUBLE
- InChIKey
- YWLXLRUDGLRYDR-IYNRKYTHSA-N
- SMILES
- O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@@]12[H]
- LogP
- 0.156 (est)
- CAS DataBase Reference
- 32981-86-5(CAS DataBase Reference)
Safety
- Hazard Codes
- T
- Risk Statements
- 23/24/25
- Safety Statements
- 45-38-36/37/39-28A-24/25
- RIDADR
- 1544
- WGK Germany
- 3
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29329990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
H340May cause genetic defects
H350May cause cancer
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- D3676
- Product name
- 10-Deacetylbaccatin III from Taxus baccata
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $371
- Updated
- 2024/03/01
- Product number
- D3676
- Product name
- 10-Deacetylbaccatin III from Taxus baccata
- Purity
- ≥95% (HPLC)
- Packaging
- 1mg
- Price
- $108
- Updated
- 2023/06/20
- Product number
- D4148
- Product name
- 10-Deacetylbaccatin III
- Purity
- >98.0%(HPLC)
- Packaging
- 100mg
- Price
- $111
- Updated
- 2024/03/01
- Product number
- D4148
- Product name
- 10-Deacetylbaccatin III
- Purity
- >98.0%(HPLC)
- Packaging
- 500mg
- Price
- $352
- Updated
- 2024/03/01
- Product number
- J66228
- Product name
- 10-Deacetylbaccatin III, 95%
- Packaging
- 25mg
- Price
- $734
- Updated
- 2021/12/16
10-Deacetylbaccatin III Chemical Properties,Usage,Production
Chemical Properties
10-Deacetylbaccatin III is White Solid
Uses
10-Deacetylbaccatin III is a intermediate in the synthesis of Taxol and derivatives
Uses
10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le
Uses
10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives.
Definition
ChEBI: 10-deacetylbaccatin III is a tetracyclic diterpenoid and a secondary alpha-hydroxy ketone. It is functionally related to a baccatin III.
General Description
10-Deacetylbaccatin III, also known as Paclitaxel Impurity 19, is an impurity of Paclitaxel. Paclitaxel is a chemotherapy drug. Chemotherapy is a treatment that destroys cancer cells using anti-cancer drugs. Paclitaxel is the non-branded name of the drug, but you may hear it called by one of its brand names such as Taxol. Some people are given a drug called nab-paclitaxel (Abraxane).
Biological Activity
10-dab (also known as 10-deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the pacific yew tree taxus brevifolia as well as other species of the genus taxus. due to the low availability of taxol from its natural sources, 10-dab is used as a raw material for the preparation of taxol and its derivatives. being easily extracted from the annual cute of the yew leaves, 10-dab has a very folded chemical structure with the α hydroxyl group hindered at c-13 easily to form a hydrogen bond with the 4α acetyl group.f. gueritte-voegelein, v. senilh, b. david, d. guenard and p. potier. chemical studies of 10-deacetyl baccatin iii hemisynthesis of taxol derivatives. tetrahedron 1986; 42(16): 4451-4460
10-Deacetylbaccatin III Preparation Products And Raw materials
Raw materials
Preparation Products
10-Deacetylbaccatin III Suppliers
- Tel
- Country
- China Hong Kong
- ProdList
- 878
- Advantage
- 55
View Lastest Price from 10-Deacetylbaccatin III manufacturers
- Product
- 10-Deacetylbaccatin III 32981-86-5
- Price
- US $6666.00/Kg/Bag
- Min. Order
- 2KG
- Purity
- 99
- Supply Ability
- 100kg
- Release date
- 2021-06-04
- Product
- 10-Deacetylbaccatin III 32981-86-5
- Price
- US $1.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-20
- Product
- 10-Deacetylbaccatin III 32981-86-5
- Price
- US $15.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 1000000tons
- Release date
- 2023-11-15