ChemicalBook > CAS DataBase List > 10-Deacetylbaccatin III

10-Deacetylbaccatin III

Product Name
10-Deacetylbaccatin III
CAS No.
32981-86-5
Chemical Name
10-Deacetylbaccatin III
Synonyms
10-DAB;10-DEACETYLBACCATIN;10-DAB Ⅲ;10-Deacetyl Baccatin lll;ó;NH24841;10DBA III;10-DAB-III;10-Dab98.5%;10-Deacetyl
CBNumber
CB3447497
Molecular Formula
C29H36O10
Formula Weight
544.59
MOL File
32981-86-5.mol
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10-Deacetylbaccatin III Property

Melting point:
231-236 °C
alpha 
-44.5 º (c=1, methanol 25 ºC)
Boiling point:
717℃
Density 
1.2007 (rough estimate)
refractive index 
1.5376 (estimate)
Flash point:
>110°(230°F)
storage temp. 
Sealed in dry,Room Temperature
solubility 
methanol: soluble, clear, colorless (5 mg + 0.1 mL MeOH)
form 
Powder
pka
11.50±0.70(Predicted)
color 
white
Water Solubility 
INSOLUBLE
InChIKey
YWLXLRUDGLRYDR-IYNRKYTHSA-N
SMILES
O1C[C@@]2(OC(C)=O)[C@@]3([H])[C@H](OC(=O)C4=CC=CC=C4)[C@@]4(O)C(C)(C)C(=C(C)[C@@H](O)C4)[C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@@]12[H]
LogP
0.156 (est)
CAS DataBase Reference
32981-86-5(CAS DataBase Reference)
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Safety

Hazard Codes 
T
Risk Statements 
23/24/25
Safety Statements 
45-38-36/37/39-28A-24/25
RIDADR 
1544
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

H340May cause genetic defects

H350May cause cancer

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0001452
Product name
Docetaxel impurity E
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
15 mg
Price
$118
Updated
2025/07/31
Sigma-Aldrich
Product number
PHR3007
Product name
10-desacetyl-baccatin III
Purity
pharmaceutical secondary standard, certified reference material
Packaging
50 mg
Price
$592
Updated
2025/07/31
Sigma-Aldrich
Product number
D3676
Product name
10-Deacetylbaccatin III from Taxus baccata
Purity
≥95% (HPLC)
Packaging
5mg
Price
$382
Updated
2025/07/31
Sigma-Aldrich
Product number
D3676
Product name
10-Deacetylbaccatin III from Taxus baccata
Purity
≥95% (HPLC)
Packaging
1mg
Price
$108
Updated
2023/06/20
TCI Chemical
Product number
D4148
Product name
10-Deacetylbaccatin III
Purity
>98.0%(HPLC)
Packaging
100mg
Price
$100
Updated
2025/07/31
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10-Deacetylbaccatin III Chemical Properties,Usage,Production

Chemical Properties

10-Deacetylbaccatin III is White Solid

Uses

10-Deacetylbaccatin III is a intermediate in the synthesis of Taxol and derivatives

Uses

10-DAB (10-Deacetylbaccatin) is an antineoplastic agent and an anti-cancer intermediate. 10-DAB (10-Deacetylbaccatin) has gained great attention because of its partly excellent anti-cancer properties. 10-DAB (10-Deacetylbaccatin) can be gained from the le

Uses

10-Deacetyl Baccatin III is an impurity of Paclitaxel (P132500) and derivatives.

Definition

ChEBI: 10-deacetylbaccatin III is a tetracyclic diterpenoid and a secondary alpha-hydroxy ketone. It is functionally related to a baccatin III.

General Description

10-Deacetylbaccatin III, also known as Paclitaxel Impurity 19, is an impurity of Paclitaxel. Paclitaxel is a chemotherapy drug. Chemotherapy is a treatment that destroys cancer cells using anti-cancer drugs. Paclitaxel is the non-branded name of the drug, but you may hear it called by one of its brand names such as Taxol. Some people are given a drug called nab-paclitaxel (Abraxane).

Biological Activity

10-dab (also known as 10-deacetylbaccatin) is an intermediate used for the preparation of taxol, an anti-leukemic and tumor-inhibiting agent isolated from the inner bark of the pacific yew tree taxus brevifolia as well as other species of the genus taxus. due to the low availability of taxol from its natural sources, 10-dab is used as a raw material for the preparation of taxol and its derivatives. being easily extracted from the annual cute of the yew leaves, 10-dab has a very folded chemical structure with the α hydroxyl group hindered at c-13 easily to form a hydrogen bond with the 4α acetyl group.f. gueritte-voegelein, v. senilh, b. david, d. guenard and p. potier. chemical studies of 10-deacetyl baccatin iii hemisynthesis of taxol derivatives. tetrahedron 1986; 42(16): 4451-4460

10-Deacetylbaccatin III Preparation Products And Raw materials

Raw materials

Preparation Products

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10-Deacetylbaccatin III Suppliers

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View Lastest Price from 10-Deacetylbaccatin III manufacturers

Wuhan JiyunZen Tech Co., Ltd.
Product
10-Deacetylbaccatin III 32981-86-5
Price
US $5.00-0.50/KG
Min. Order
1KG
Purity
99% hplc
Supply Ability
500TONS
Release date
2025-05-08
Shaanxi Dideu New Materials Co. Ltd
Product
10-Deacetylbaccatin III 32981-86-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-12
Baoji Guokang Healthchem Co., Ltd.
Product
10-Deacetylbaccatin III 32981-86-5
Price
US $6666.00/Kg/Bag
Min. Order
2KG
Purity
99
Supply Ability
100kg
Release date
2021-06-04

32981-86-5, 10-Deacetylbaccatin IIIRelated Search:

Acetylferrocene Acetylacetone N-ACETYL-L-TYROSINE ETHYL ESTER Baccatine III (2R,3S)-N-Benzoyl-3-phenyl Isoserine Docetaxel Metabolite M4 10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl Docetaxel Impurity 36 Docetaxel (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate HLCSYHHJEMPKSY-RRKHLBDSSA-N 4-Dichloroethoxy-carbonyl docetaxel 2-Azetidinone, 3-hydroxy-4-phenyl-1-[(1S)-1-phenylethyl]-, (3R,4S)- Docetaxel Impurity 15

  • 10-Deacetyl Baccatin lll
  • Deacetylbaccatin III
  • 10-deacetylbaccatin11
  • 10-deacetylbaccatiniii(extaxusbaccata)
  • 10-DAB
  • 10-DEACETYLBACCATIN III FROMTAXUS BACCAT A
  • 10-Dab98.5%
  • 10-Deacetylbaccatine(III)
  • 10-Deacetyl Baccatin &cent
  • 10-Deacetylbaccatine
  • 10-DAB III(10-DEACETYL BACCATIN III) 99%
  • DEACETYLBACCATIN-III, 10(P)
  • 10-DAB(10-deacetylbaccatin)
  • 10-Deacetyl
  • DESACETYLBACCATINE
  • BACCATIN III, 10-DEACETYL-
  • 10-Deacetylbaccatin III
  • 10-O-DEACETYLBACCATIN III
  • high quality 10-deacetylbacctin Ⅲ(10-DAB) CAS 32981-86-5 CAS NO.32981-86-5
  • 2-bromo-4-chloropropiophenone CAS NO.877-37-2
  • 10-Deacetylbaccatin III 32981-86-5
  • Paclitaxel Impurity 19
  • Docetaxel EP impurity E，10-desacetyl-baccatin III
  • 10-Deacetylbacatin III
  • Docetaxel IMpurity E (10-Deacetyl Baccatin III)
  • ó
  • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one, 12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-
  • Docetaxel impurity E
  • 10-Deacetylbaccatin III, >=99%
  • 10-deacetyl Chiba Cardin Ⅲ
  • 12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3
  • (2AR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-
  • 10-DEACETYLBACCATIN III (EX TAXUS BACCATA), CONTAINS CA 0.5 MOLE OF METHANOL 95%
  • 10-DEACETYL BACCATIN (10-DAB )
  • 10-Desacetylbaccatin III
  • 7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one,12b-(acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-,[2aR-(2aα,4β,4aβ,6β,9α,11α,12α,12aα,12bα)]-
  • 12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • 10-DAB-III
  • 10-DEACETYLBACCATIN
  • 10-DEACETYLBACCATIN III, 95%, FROM TAXUS BACCATA
  • 10-Deacetyl Baccatin ￠ó
  • 12b-(Acetyloxy)-12-(Benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-Dodecahydro-4,6,9,11-Tetrahydroxy-4a,8,13,13-Tetramethyl-7,11-Methano-5h-Cyclodeca[3,4]
  • 10-Deacetylbaccatin III ,97%
  • 10-DAB Ⅲ
  • 10-Decaacetyl baccatin III
  • 10DBA III
  • 10-Deacetyl baccatine IIII
  • 10-Deacetylbaccatin Ⅲ(10-DAB)
  • 5β,20-Epoxy-4-(acetyloxy)-1,7β,10β,13α-tetrahydroxy-9-oxotax-11-en-2α-yl benzoate
  • (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetraMethyl-7,11-Methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one
  • Docetaxel EP Impurity E
  • Docetaxel Impurity 5(Docetaxel EP Impurity E)
  • NH24841
  • 10-DAB：10-Deacetylbaccatin III
  • Docetaxel EP Impurity E (10-Deacetyl Baccatin III)
  • 10-DeacetylbaccatinIII&gt
  • Docetaxel impurity E CRS
  • 3-(5-chloro-2-fluorobenzyl)isonicotinic acid