4-Chloro-2-(trifluoromethyl)benzonitrile

Application

Product Name: 4-Chloro-2-(trifluoromethyl)benzonitrile
CAS No.: 320-41-2
Chemical Name: 4-Chloro-2-(trifluoromethyl)benzonitrile
Synonyms: oro-2-(trifL;3-Chloro-6-cyanobenzotrifluoride;5-CHLORO-2-CYANOBENZOTRIFLUORIDE;5-Chloro-2-cyanobenzotrifluoride98%;5-Chloro-2-cyanobenzotrifluoride 98%;2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE;4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE;4-chloro-2-(trifluoronethyl)benzonitrile;Benzonitrile, 4-chloro-2-(trifluoromethyl)-;4-Chloro-2-(trifluoromethyl)benzonitrile 98%
CBNumber: CB3454545
Molecular Formula: C8H3ClF3N
Formula Weight: 205.56
MOL File: 320-41-2.mol

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4-Chloro-2-(trifluoromethyl)benzonitrile Property

Boiling point:: 109/10mm
Density: 1.43±0.1 g/cm3(Predicted)
refractive index: 1.4950
storage temp.: 2-8°C
CAS DataBase Reference: 320-41-2(CAS DataBase Reference)

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Safety

Hazard Codes: T
RIDADR: UN3276
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P309IF exposed or if you feel unwell:

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC

Product number: C598240
Product name: 4-Chloro-2-(trifluoromethyl)benzonitrile
Packaging: 500mg
Price: $60
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3837-7-42
Product name: 5-Chloro-2-cyanobenzotrifluoride
Purity: 97%
Packaging: 1g
Price: $45
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3837-7-42
Product name: 5-Chloro-2-cyanobenzotrifluoride
Purity: 97%
Packaging: 5G
Price: $95
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0023305
Product name: 4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE
Purity: 95.00%
Packaging: 1G
Price: $629.48
Updated: 2021/12/16

Matrix Scientific

Product number: 116561
Product name: 4-Chloro-2-(trifluoromethyl)benzonitrile
Packaging: 5g
Price: $203
Updated: 2021/12/16

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4-Chloro-2-(trifluoromethyl)benzonitrile Chemical Properties,Usage,Production

Application

4-Chloro-2-trifluoromethylbenzonitrile (1) is an important intermediate in the synthesis of bicalutamide. In addition, due to its multiple reaction sites, it is widely used in the preparation of pharmaceutical and chemical intermediates.

Chemical Properties

Yellow liquid

Synthesis

23399-77-1

557-21-1

320-41-2

General procedure for the synthesis of 2-trifluoromethyl-4-chlorobenzonitrile from 2-iodo-5-chlorobenzotrifluoride and zinc cyanide: 4-chloro-1-iodo-2-trifluoromethylbenzene (1500 mg, 4.89 mmol), zinc cyanide (345 mg, 2.94 mmol) and tetrakis(triphenylphosphine)palladium(0) (564 mg, 0.488 mmol), then N,N-dimethylformamide (40 mL) was added. The reaction mixture was heated at 80 °C for overnight reaction. After the reaction was completed, it was cooled to room temperature, the reaction solution was diluted with toluene, washed sequentially with 2N ammonium hydroxide solution (3 times) and saturated aqueous sodium chloride solution, and the organic phase was filtered after drying and concentrated to obtain the crude product. The crude product was purified by silica gel column chromatography with hexane/dichloromethane as eluent to give 4-chloro-2-trifluoromethylbenzonitrile (630 mg, 63% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.81-7.78 (m, 2H), 7.67 (dd, 1H, J = 8.4, 2.4 Hz).

References

[1] Patent: WO2006/44454, 2006, A1. Location in patent: Page/Page column 63

4-Chloro-2-(trifluoromethyl)benzonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-2-(trifluoromethyl)benzonitrile Suppliers

China 129 Europe 1 Germany 6 India 2 Italy 1 Japan 1 The Netherlands 1 United Kingdom 8 United States 28 Global 177

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Pure Chemistry Scientific Inc.

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View Lastest Price from 4-Chloro-2-(trifluoromethyl)benzonitrile manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-11-12

Shaanxi Dideu Medichem Co. Ltd

Product: 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20t
Release date: 2024-05-21

Career Henan Chemical Co

Product: 4-Chloro-2-(trifluoromethyl)benzonitrile 320-41-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 200KG
Release date: 2020-01-08

320-41-2, 4-Chloro-2-(trifluoromethyl)benzonitrileRelated Search:

4-chloro-2-(trifluoronethyl)benzonitrile

2-trifluoromethyl-4-chlorophenyl-carbonitrile

2-TRIFLUOROMETHYL-4-CHLOROBENZONITRILE

5-CHLORO-2-CYANOBENZOTRIFLUORIDE

4-CHLORO-2-(TRIFLUOROMETHYL)BENZONITRILE

3-Chloro-6-cyanobenzotrifluoride

5-Chloro-2-cyanobenzotrifluoride 98%

5-Chloro-2-cyanobenzotrifluoride98%

4-Chloro-2-(trifluoromethyl)benzonitrile 98%

5-Chloro-2-cyanobenzotrifluoride, 4-Chloro-alpha,alpha,alpha-trifluoro-o-tolunitrile

oro-2-(trifL

Benzonitrile, 4-chloro-2-(trifluoromethyl)-

320-41-2

320-41-4

Fluorine series

Fluorobenzene