1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- Product Name
- 1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- CAS No.
- 474944-25-7
- Chemical Name
- 1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE
- Synonyms
- C16-04:1 PC;BUTENOYL PAF;1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE;1-O-HEXADECYL-2-O-(2E-BUTENOYL)-SN-GLYCERYL-3-PHOSPHOCHOLINE;[(2R)-2-[(E)-But-2-enoyl]oxy-3-hexadecoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate
- CBNumber
- CB3456857
- Molecular Formula
- C28H56NO7P
- Formula Weight
- 549.72
- MOL File
- Mol file
1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Property
- storage temp.
- Store at -20°C
- solubility
- ≤0.5mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- solution in ethanol.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 60929
- Product name
- Butenoyl PAF
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $79
- Updated
- 2024/03/01
- Product number
- 60929
- Product name
- Butenoyl PAF
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $351
- Updated
- 2024/03/01
- Product number
- 60929
- Product name
- Butenoyl PAF
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $623
- Updated
- 2024/03/01
- Product number
- 60929
- Product name
- Butenoyl PAF
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $2716
- Updated
- 2024/03/01
- Product number
- C5385
- Product name
- ButenoylPAF
- Packaging
- 5mg(solution)
- Price
- $400
- Updated
- 2021/12/16
1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Chemical Properties,Usage,Production
Uses
Butenoyl-PAF is a phospholipid analog of platelet activating factor (PAF-like) that is generated in oxidized low-density lipoprotein (DLDR). Butenoyl-PAF can activate cells that express human PAF receptors, such as neutrophils, monocytes, and platelets, and it stimulates an increase in intracellular calcium ion concentration[1].
Definition
ChEBI: PC(O-16:0/4:1) is a phosphatidylcholine O-20:1.
Biological Activity
butenoyl paf is a paf receptor agonist [1].platelet activating factor (paf), a phospholipid mediator of inflammation, is secreted by several cell types including arterial endothelial cells, and can activate polymorphonuclear leucocytes and monocytes via specific cell surface receptors. paf also stimulates the production of active oxygen species by human monocyte - derived macrophages. paf play important roles in a variety of pathophysiological states including acute allergy, inflammation, asthma, gastrointestinal ulceration, and toxic shock [1][2].butanoyl-paf and butenoyl paf are both products of the oxidative decomposition of 2-arachidonoyl phospholipids. although butenoyl paf is 10-fold less potent than paf as a paf receptor agonist and ligand, it is 100-fold more abundant in oxidized ldl than paf. therefore, oxidation products of ldl phospholipids were physiologically relevant bioactive paf-like molecules [1].
References
[1]. marathe gk, davies ss, harrison ka, et al. inflammatory platelet-activating factor-like phospholipids in oxidized low density lipoproteins are fragmented alkyl phosphatidylcholines. j biol chem. 1999 oct 1;274(40):28395-404.
[2]. davies ss, pontsler av, marathe gk, et al. oxidized alkyl phospholipids are specific, high affinity peroxisome proliferator-activated receptor gamma ligands and agonists. j biol chem. 2001 may 11;276(19):16015-23.
1-O-HEXADECYL-2-BUTENOYL-SN-GLYCERO-3-PHOSPHOCHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
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