7-AVCA
- Product Name
- 7-AVCA
- CAS No.
- 79349-82-9
- Chemical Name
- 7-AVCA
- Synonyms
- 7-AMINO-3-VINYLCEPHALOSPORANIC ACID;(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA/(6R,7R)-7-AMino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;7-AVCA;Cefixime Impurity 8;Cefdinir Impurity 30;Cefixime Inermediates;Cefdinir CP Impurity C;Cefdinir Impurity C(CP);Cefixime Impurity 7 AVCA
- CBNumber
- CB3457874
- Molecular Formula
- C9H10N2O3S
- Formula Weight
- 226.25
- MOL File
- 79349-82-9.mol
7-AVCA Property
- Melting point:
- 215-220°C
- Boiling point:
- 540.7±50.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- solubility
- Aqueous Base (Slightly), DMSO (Slightly)
- form
- Solid
- pka
- 2.73±0.50(Predicted)
- color
- White to Pale Yellow
- InChI
- InChI=1S/C9H10N2O3S/c1-2-4-3-15-8-5(10)7(12)11(8)6(4)9(13)14/h2,5,8H,1,3,10H2,(H,13,14)/t5-,8-/m1/s1
- InChIKey
- GQLGFBRMCCVQLU-SVGQVSJJSA-N
- SMILES
- N12[C@@]([H])([C@H](N)C1=O)SCC(C=C)=C2C(O)=O
- CAS DataBase Reference
- 79349-82-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P321Specific treatment (see … on this label).
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A632600
- Product name
- 7-Amino-3-vinyl-3-cephem-4-carboxylicAcid
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- FA17544
- Product name
- 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- J20661
- Product name
- 7-AVCA
- Packaging
- 1g
- Price
- $98
- Updated
- 2021/12/16
- Product number
- FA17544
- Product name
- 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
- Packaging
- 2g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- FA17544
- Product name
- 7-Amino-3-vinyl-3-cephem-4-carboxylic acid
- Packaging
- 5G
- Price
- $150
- Updated
- 2021/12/16
7-AVCA Chemical Properties,Usage,Production
Chemical Properties
White Solid
Uses
A key intermediate in the manufacturing of Cephalosporin compounds.
Synthesis
33748-00-4
79349-82-9
The general procedure for the synthesis of (6R,7R)-7-amino-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid from cefixime impurity is as follows: 25.5 g (0.05 mol) of GVNA was placed in a 1,000 mL three-necked flask fitted with a thermometer and a mechanical stirrer, and 300 g of phenol and 2.8 g of acetic acid and the reaction was held at 35°C. After the reaction was complete (about 6 hours), the reaction mixture was slowly poured into a mixed solution consisting of sodium bicarbonate, purified water, and butyl acetate (5 g of purified water, 200 mL of purified water, and 200 mL of butyl acetate). The aqueous phase was extracted twice with 50 mL of butyl acetate and the aqueous phases were combined. The aqueous phase was transferred to a 500 mL reaction flask and stirred at room temperature for 2 hours. 4 g of immobilized acyltransferase PGA-450 was added, followed by dropwise addition of 15% aqueous sodium carbonate solution, maintaining the pH between 8.0-8.2 until the HPLC assay showed less than 0.5% GVNA. The enzyme was recovered by filtration. The filtrate was collected and the pH was adjusted with 10% hydrochloric acid to 3.4. The filter cake was washed with 50 mL of acetone and dried to give 10.7 g of AVNA (93.8% yield as GVNA).
References
[1] Patent: CN104045655, 2016, B. Location in patent: Paragraph 0061
[2] Organic Process Research and Development, 2009, vol. 13, # 5, p. 924 - 927
[3] Patent: CN103923104, 2016, B. Location in patent: Paragraph 0032-0034
7-AVCA Preparation Products And Raw materials
Raw materials
Preparation Products
7-AVCA Suppliers
- Tel
- --
- Fax
- --
- Sales@casorganic.com
- Country
- Ukraine
- ProdList
- 5026
- Advantage
- 34
View Lastest Price from 7-AVCA manufacturers
- Product
- 7-AVCA 79349-82-9
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-08-21
- Product
- Cefdinir Impurity C 79349-82-9
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2025-02-12
- Product
- Cefixime Impurity 8
- Price
- US $0.00-0.00/mg
- Min. Order
- 5mg
- Purity
- 95%+
- Supply Ability
- 1000mg
- Release date
- 2024-12-20