Phenylglycylcefalexin
- Product Name
- Phenylglycylcefalexin
- CAS No.
- 72528-40-6
- Chemical Name
- Phenylglycylcefalexin
- Synonyms
- Phenylglycyl Cep;Cefalexin Impurity;Cefalexin impurity C;Phenylglycylcefalexin;Cephalexin EP Impurity;Cefalexin EP Impurity C;Cephalexin EP Impurity C;D-Phenylglycyl Cephalexin;Phenylglycyl Cephalexin TFA Salt;Cefalexin Impurity 3(EP Impurity C)
- CBNumber
- CB42622628
- Molecular Formula
- C24H24N4O5S
- Formula Weight
- 480.54
- MOL File
- 72528-40-6.mol
Phenylglycylcefalexin Property
- Melting point:
- >207°C (dec.)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Aqueous Acid (Slightly, Sonicated, Heated), DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- color
- Off-White to Pale Beige
- InChIKey
- DMRMXTUJVSARRA-BXKYNXKVNA-N
- SMILES
- C(NC(=O)[C@H](C1=CC=CC=C1)N)(=O)[C@H](C1=CC=CC=C1)N[C@@H]1C(=O)N2[C@]1([H])SCC(C)=C2C(O)=O |&1:4,13,21,25,r|
N-Bromosuccinimide Price
- Product number
- P327140
- Product name
- PhenylglycylCephalexin(Mixtureofdiastereomers)
- Packaging
- 10mg
- Price
- $1190
- Updated
- 2021/12/16
Phenylglycylcefalexin Chemical Properties,Usage,Production
Uses
D-Phenylglycyl Cephalexin is an impurity of Cephalexin (C256800).
Uses
Phenylglycyl Cephalexin (Cefalexin EP Impurity C) is an impurity of Cephalexin (C256800).
Synthesis
N-BOC-o-phenylglycine (753 mg, 3 mmol) was dissolved in a mixture of tetrahydrofuran (THF) (15 ml), Et3N 0.42 ml (3 mmol), and 3 drops of N-methylmorpholine, and stirred for 10 min at -15 C. Isobutyl chloroformate (0.41 ml, 3 mmol) in 2 ml of THF was added dropwise. After stirring at -15C for 20 min, 1.1 g (3 mmol) of cefadroxil was dissolved in 10 ml of THF-H2O (1:l) containing 0.42in1 (3 mmol) of Et,N. Add. The mixture was stirred at 0C for 3 hours. THF was removed by evaporation.H2O (10 ml) was added and the pH was adjusted to 2 with 2NHCl.The solution was then extracted with EtOAc (3 20 ml). Combined tissues. The aqueous layer was washed with H2O (20 ml), dried with anhydrous MgSO4, filtered and evaporated. The residue was dissolved in about 2 ml of fluoroacetic acid and stored at room temperature. It lasted for 16 hours. The solution was evaporated and the residue dissolved in water was placed on an anion exchange column (Bio-RadAG-3, 200-400 mesh, acetate, 13 x 2 cm) and eluted with water to remove trifluoroacetic acid. The eluate was evaporated and the residue was crystallized from acetone-water and dried under vacuum. Cefadroxil EP impurity C yielded 900 mg (63%).
Phenylglycylcefalexin Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Phenylglycylcefalexin manufacturers
- Product
- Phenylglycylcefalexin 72528-40-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100kg
- Release date
- 2020-03-11